My Latest Experimentation

My Latest Experimentation:

I've recently begun my own, safer & potentially more effective version of the TRIIM Trial - Thymic Rejuvenation and Immunorestoration and Insulin Mitigation.

This trial was initially designed to test whether a cocktail of DHEA, metformin and growth hormone (GH) could rejuvenate the thymus. On further inspection, the team made the ground-breaking discovery, that the drug cocktail had wound back the biological age of the participants.

Longevity Briefs: TRIIM - The Trial that reversed Human Ageing | Dr. Greg Fahy - Gowing Life 

I've already been taking DHEA to lend support to my age-declined levels, but to match the protocol specifications, Iwill eventually have to increase my dosage. 

However, I do not wish to take metformin due to it's negative impact on mitochondria, nor GH due to its potential to promote cancer, so I opted instead for equal substitutions that would be just as (if not much more) effective, and then I used several different AIs to test & validate my reasoning.

Supplements to Replace Metformin:

1. Berberine - Activates AMPK, reduces hepatic glucose production, improves insulin sensitivity. Berberine's mechanisms closely mirror those of metformin, particularly its action on AMPK.

2. Alpha-Lipoic Acid (ALA) - Acts as an antioxidant, improves insulin sensitivity, supports mitochondrial function. ALA can help reduce oxidative stress and improve glucose metabolism, complementing the effects of berberine.

But R-Lipoic Acid is the preferred form over Standard ALA, and here's why:

a. Higher Bioavailability: R-Lipoic Acid is the naturally occurring form of ALA and is more readily absorbed and utilized by the body compared to the synthetic form (which is a 50/50 mixture of R-ALA and S-ALA).

b. Greater Potency: R-Lipoic Acid has been shown to be more potent in its antioxidant effects and in improving insulin sensitivity.

c. Enhanced Efficacy: Because it is more bioavailable and potent, lower doses of R-ALA can achieve similar or better results compared to higher doses of standard ALA.

3. Resveratrol - Reportedly activates sirtuins and AMPK, promotes mitochondrial biogenesis, reduces inflammation. Resveratrol supports anti-aging pathways and enhances mitochondrial function, which aligns with the goals of the TRIIM trial.

But there's been a lot of controversy as to whether or not Resveratrol actually does activate sirtuins. So I opted to replace Resveratrol with Quercetin in my TRIIM trial protocol, and here's why:

• Anti-inflammatory and Antioxidant Properties: Both quercetin and resveratrol have strong anti-inflammatory and antioxidant properties. However, quercetin is particularly noted for its broad spectrum of activity, which might provide more comprehensive benefits in reducing oxidative stress and inflammation.

• Bioavailability: Quercetin has better bioavailability compared to resveratrol. This means that a higher percentage of quercetin is absorbed and utilized by the body, potentially making it more effective at lower doses.

• Immune Support: Quercetin has been shown to support immune function by modulating immune cell activity and reducing the incidence of infections, particularly upper respiratory infections. This might be particularly beneficial if immune support is a priority in your protocol.

• Senolytic Effects: Quercetin is known to have senolytic properties, meaning it can help clear out senescent (aging) cells, which are associated with aging and various diseases. This could be advantageous for overall longevity and health span improvement.

• Cardiovascular Health: While both compounds support cardiovascular health, quercetin has been specifically associated with improved endothelial function, reduced blood pressure, and better lipid profiles, which might be more aligned with your specific cardiovascular goals.

• Metabolic Health: Quercetin has been shown to improve insulin sensitivity and glucose metabolism, which can be beneficial for metabolic health and managing conditions like insulin resistance and type 2 diabetes.

And finally, I opted to use a growth hormone secretagogue (GHS), namely CJC-1295/Ipamorelin, instead of human growth hormone (HGH), in an attempt to stimulate my body's own production of growth hormone. GHS peptides can be a more natural and potentially safer alternative to direct HGH supplementation.

My Final TRIM TRIAL Protocol 

• Using Berberine, R-Lipoic Acid, and Quercetin to replace Metformin

• Using CJC-1295/Ipamorelin to replace HGH

• Using low initial supplement & peptide dosages and increase after a few months of monitoring.

Utilizing multiple AIs to calculate & validate the comparable dosage substitutions for Metformin and HGH that were set out in the original TRIMM Trial protocol, the results for my specific body-weight calculates out to be:

1. Berberine: 500 mg, three times daily (Total: 1,000-1,500 mg)

2. R-Lipoic Acid: 100-200 mg, twice daily (Total: 200-400 mg)

3. Quercetin: 500-1,000 mg, once or twice daily (Total: 500-2,000 mg)

4. CJC-1295/Ipamorelin: 300 mcg per injection, once or twice daily (Total: 300-600 mcg)

5. DHEA: 25-50 mg, once daily

And taken in the following Starting Dosage Schedule:

Morning:

- Berberine: 500 mg

- R-Lipoic Acid: 100-200 mg

- Quercetin: 500 mg (or 1,000 mg if dosing only once daily)

- DHEA: 25-50 mg

- CJC-1295/Ipamorelin: 300 mcg (or 600 mcg if dosing only once daily)

Afternoon (optional):

- Berberine: 500 mg

- Quercetin: 500 mg

- CJC-1295/Ipamorelin: 300 mcg (if dosing twice daily)

Evening:

- Berberine: 500 mg

- R-Lipoic Acid: 100-200 mg

- CJC-1295/Ipamorelin: 300 mcg

Final Recommendations:

1. **Consult a healthcare professional** before starting this protocol to ensure it's appropriate for your needs.

2. **Regularly monitor health markers and responses** to adjust dosages if necessary.

3. **Maintain a balanced diet and exercise routine** to support overall health and maximize the benefits of the protocol.

So far, my sleep scores have been better than they've ever been!