Integrative Medicine

Approach to Disorder of Gut Brain Interaction: https://www.mayoclinicproceedings.org/article/S0025-6196(22)00618-8/fulltext 

Case Videos for Disorders of Gut Brain Interaction: https://www.uclahealth.org/medical-services/gastro/ibs/videos 

• 25% of depressed patients w/trauma (in presenters' data): myelopoiesis-->  immune subtype, w/inflammatory markers are elevated, cbc with diff with upregulated myloid cells (neutrophils, monocytes); they are also more reactive to stress (liposacchride? administered)

• myeloid cells, BBB permeability increases in people with depression, trauma

• stressed mice (bullied by aggressor mice): develop insulin resistance, obesity, overeating after stressor is removed, gut inflammation and IBS sx; increased myeloid cells including neutrophils and monocytes (no other differences of other cells)

• dysbiosis--> leaky gut (increased gut permeability)--> lipopolysaccharides (byproduct of gut bateria metabolism) gets through (myeloid agonist) and enters blood stream--> more inflammatory states 

• LPS can also cross BBB (microglia in brain are responding to LPS) so there is central and peripheral inflammatory response. 

• Periventricular hypothalamus stim--> CRH--> celiac gangion stimulation --> produces social avoidance behavior (this is all in absence of stress!). classic HPA axis. 

• HPA blocker injected (meterpone)--> denervate the colon. 

• psychiatric 

• Tian S, Liang Z, Tian M, Qiu F, Yu Y, Mou H, Gao Y. Comparative efficacy of various exercise types and doses for depression in older adults: a systematic review of paired, network and dose-response meta-analyses. Age Ageing. 2024 Oct 1;53(10):afae211. doi: 10.1093/ageing/afae211. PMID: 39348911.