PDX Pancreatic cancer model

Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. PDX models are used to create an environment that allows for the natural growth of cancer, its monitoring treatment evaluations for the patient. The robust growth needed for efficacy studies is usually confirmed by growth curves, which can also show variability in growth for a certain model. These can be combined with any available treatment data to see how the model responds to SoC or experimental agents, if models are treatment resistant, and to explore response variability vs. background. Certain disease types should also be available with specific information. With blood cancer models such as AML, for example, you could also expect to find patient primary blood test results, primary marrow morphology, and model phenotyping for antigen expression. PDX are actually an ideal model for immunotherapy studies as they can capture the characteristics and diversity of the human clinical oncology population. Tumors may also use different mechanisms to interact or interfere with the immune system, which PDX could also recapitulate.