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Patient-Derived Xenograft Models of Colon Cancer
Patient-Derived Xenograft Models of Colon Cancer
Colon cancer Patient-derived xenograft (PDX) models display a true representation of the human genetic and phenotypic heterogeneity seen in patient populations Colorectal PDX models are the ideal tools to use when drug development programs are gearing up for clinical trials, as they have been shown to be the most predictive xenograft model available. Colon PDX models have growth and response to SoC correlate well with patient clinical response, providing highly predictive data for guidance on indication or patient clinical stratification. Find our full collection at: https://models.crownbio.com/model/pdx/colorectal-cancer/
Patient-Derived Xenograft Models of Colorectal Cancer
Patient-Derived Xenograft Models of Colorectal Cancer
PDX, on the other hand, are generated by taking patient tumor tissue and directly implanting into a mouse, never growing in vitro. Subject to the implanted tissue “taking” in the host and achieving reasonable growth rates, the tumor tissue is subsequently passaged into further animals (P1, Pn, etc.) and becomes a PDX model. These models are constantly maintained in vivo, with heterogeneous cell types and a tumor microenvironment closely mimicking that of human tumors.
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