Breast cancer Patient-derived xenografts - PDX offer the most translational preclinical model for efficacy screening in Breast cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, breast cancer patient derived xenograft models reflect the heterogeneity and diversity of the human patient population. PDX provide stable models which more closely recapitulate the characteristics of the parental tumor than traditional xenografts – such as histo- and molecular pathology, driver mutations, and oncogenic changes – offering a more predictive alternative for preclinical drug evaluation. Click this link to see our full line up of Breast Cancer PDX Models https://models.crownbio.com/model/pdx/breast-cancer/
Over 95% of new drugs fail Phase II and Phase III clinical trials due to a lack of efficacy and biomarker discovery. Our Translational Oncology Platforms reduce these attrition rates while improving the efficiency of oncology drug development and lowering your developmental costs. PDX are actually an ideal model for immunotherapy studies as they can capture the characteristics and diversity of the human clinical oncology population. Tumors may also use different mechanisms to interact or interfere with the immune system, which PDX could also recapitulate.