Wildtype Spike Protein

SARS-CoV-2 full-length spike protein (trimeric)

PDB ID: 6VSB

Sequence length: 1273 amino acids

UniProt ID: P0DTC2

S1 subunit: Residues 14-686

N-terminal domain (NTD) Residues 14-306

Receptor binding domain (RBD)* Residues 331-528

C-terminal domain 1 (CTD1) Residues 529-591

C-terminal domain 2 (CTD2)** Residues 592-686

* Receptor binding motif Residues 436-506

** Furin cleavage site Residues 681-684

S2 subunit: Residues 816-1273

Fusion peptide (FP) Residues 816-836

Fusion-peptide proximal region (FPPR) Residues 837-857

Heptad repeat 1 (HR1) Residues 911-985

Central helix (CH) Residues 986-1036

Connector domain (CD) Residues 1037-1068

Heptad repeat 2 (HR2) Residues 1164-1211

Transmembrane segment (TM) Residues 1212-1234

Cytoplasmic tail (CT) Residues 1235-1273

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