Bacteria such as Escherichia coli are capable of sensing chemical gradients and swimming towards favorable chemicals or away from harmful chemicals. The understanding of this phenomenon, known as Chemotaxis, is important because of its relevance in cancer, immunology, and microbiology. The main aim of the current work is to study the response of microorganisms in the presence of chemical gradients in microchannels. We model the swimming of bacteria and integrate it with the chemotaxis pathway to predict motion in the presence of chemicals. More recently, we are trying to unravel the workings of the flagellar motor, especially how they recruit stators to modulate their rotation speed on sensing a chemical.