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Welcome Bing-Nuo Lee, joining our group as a research assistant!
Bing-Nuo is a chemist by training and graduated from National Taiwan University. His research focuses on transition-state calculations in organic reactions. He will now expand his interests to more complex enzyme systems and explore how the structure of biomolecules influences catalytic efficiency.
Jul 30, 2026
Welcome aboard to Ling-Rong Wu and Hsia Chun, joining our group this July for their MS thesis work!
A huge welcome to our new master's students, Ling-Rong Wu and Hsia Chun, who joined us this July! They will be diving into the world of reactive intermediates and mechanisms for their MS theses. Thrilled to have you both on board!.
Jul 06, 2026
Dr. Chun-Wei Chang awarded startup grant by the Institute of Chemistry, Academia Sinica (2026–2027)
Dr. Chang has secured an Startup Grant from IOC (2026–2027) to establish his research program at the Institute of Chemistry. The grant will fund advanced instrumentation and support the lab's first cohort of researchers.
Jul 03, 2026
Breaking the Fortress: Reshaping the Barriers of Pancreatic Cancer
Our lab is dedicated to defeating pancreatic cancer—often called the "King of Cancers" due to its low survival rates. The main challenge is the tumor's tough, fibrous environment. Specifically, a substance called hyaluronic acid (HA) builds up and creates high pressure, forming a "shield" that blocks medicine from reaching the cancer cells. To break through this barrier, we use chemical synthesis and precision analysis to study how biological molecules fold and assemble. By understanding these structures, we aim to design smarter ways to penetrate the tumor shield and deliver life-saving treatments more effectively.
Mapping the Transition: Visualizing the Life of Short-Lived Intermediates
Structural analysis is at the heart of molecular science. However, relying on a single method often leaves "blind spots." To see the full picture, our lab integrates four core technologies: Organic Synthesis, Computer Simulation, Nuclear Magnetic Resonance (NMR), and Precision Mass Spectrometry. By combining these multidimensional tools, we can precisely capture how biological molecules fold and assemble in real-time. This cross-disciplinary approach allows us to uncover the microscopic rules of the tumor environment, helping us design innovative ways to break through cancer’s defenses.
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