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Welcome Bing-Nuo Lee, joining our group as a research assistant!
Bing-Nuo is a chemist by training and graduated from National Taiwan University. His research focuses on transition-state calculations in organic reactions. He will now expand his interests to more complex enzyme systems and explore how the structure of biomolecules influences catalytic efficiency.
Jul 30, 2026
Welcome aboard to Ling-Rong Wu and Hsia Chun, joining our group this July for their MS thesis work!
A huge welcome to our new master's students, Ling-Rong Wu and Hsia Chun, who joined us this July! They will be diving into the world of reactive intermediates and mechanisms for their MS theses. Thrilled to have you both on board!.
Jul 06, 2026
Dr. Chun-Wei Chang awarded startup grant by the Institute of Chemistry, Academia Sinica (2026–2027)
Dr. Chang has secured an Startup Grant from IOC (2026–2027) to establish his research program at the Institute of Chemistry. The grant will fund advanced instrumentation and support the lab's first cohort of researchers.
Jul 03, 2026
Selected Publications
Chun-Wei Chang, D. Wehner, G. R. D. Prabhu, E. Moon, M. Safferthal, L. Bechtella, N. Österlund, G. M. Vos, K. Pagel. Elucidating Reactive Sugar-intermediates by Mass Spectrometry. Commun. Chem. 2025, 8, 67. Link
Chun-Wei Chang, K. Greis, G. R. Prabhu, D. Wehner, C. Kirschbaum, K. Ober, A. Torres-Boy, S. Leichnitz, G. Meijer, G. von Helden, P. H. Seeberger, K. Pagel. Mechanistic Insight into Benzylidene-Directed Glycosylations Reactions using Cryogenic Infrared Spectroscopy. Nat. Synth. 2024, 3, 1377-1384. Link
Chun-Wei Chang, K. Pagel. Structure of the Cationic Intermediate in Benzylidene-directed Glycosylation. Nat. Synth. 2024, 3, 1325-1326. Link
Chun-Wei Chang, M.-H. Lin, T.-Y. Chiang, C.-H. Wu, T.-C. Lin, and C.-C. Wang. Unraveling the Promoter Effect and the Roles of Counterions Exchange in Glycosylation Reaction. Sci. Adv. 2023, 9, eadk0531. Link
Chun-Wei Chang, M.-H. Lin, C.-K. Chan, K.-Y. Su, C.-H. Wu, W.-C. Lo, S. Lam, Y.-T. Cheng, P.-H. Liao, C.-H. Wong, C.-C. Wang. Automated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions. Angew. Chem. Int. Ed. 2021, 60, 12413-12423. Link
Chun-Wei Chang, M.-H. Lin, C.-C. Wang. Statistical Analysis in Glycosylation Reaction. Chem. - Eur. J. 2021, 27, 2556-2568. Link
Chun-Wei Chang, M.-H. Lin, C.-H. Wu, T.-Y. Chiang, C.-C. Wang. Mapping Mechanisms in Glycosylation Reactions with Donor Reactivity: Avoiding Generation of Side Products. J. Org. Chem. 2020, 85, 15945-15963. (cover page) Link
Chun-Wei Chang C.-H. Wu, M.-H. Lin, P.-H. Liao, C.-C. Chang, H.-H. Chuang, S.-C. Lin, S. Lam, V. P. Verma, C.-P. Hsu, C.-C. Wang. Establishment of Guidelines for the Control of Glycosylation Reactions and Intermediates by Quantitative Assessment of Reactivity. Angew. Chem. Int. Ed. 2019, 58, 16775-16779. Link
Co-authored Publications
T.-Y. Chiang, M.-H. Lin, Chun-Wei Chang, J.-C. Lee, C.-C. Wang. Structural Analysis of Stereoselective Galactose Pyruvylation Toward the Synthesis of Bacterial Capsular Polysaccharides. Beilstein J. Org. Chem. 2025, 21, 1671-1677. Link
N. Geue, K. Greis, S. Omoregbee-Leichnitz, C. Kirschbaum, Chun-Wei Chang, G. Meijer, G. von Helden, P. H. Seeberger, K. Pagel. Influence of Levulinoyl Protecting Groups on Glycosylation Stereoselectivity and Glycosyl Cation Structure. Eur. J. Org. Chem. 2025, 28, e202500732. Link
M. Safferthal, K. Greis, R. Chang, Chun-Wei Chang, W. Hoffmann, G. Meijer, G. von Helden, K. Page. The Impact of Side-chain Fluorination on Proton-bound Phenylalanine Dimers: A Cryogenic Infrared Spectroscopic Study. Phys. Chem. Chem. Phys. 2024, 26, 28155. Link
K. Greis, S. Leichnitz, C. Kirschbaum, Chun-Wei Chang, M.-H. Lin, G. Meijer, G. von Helden, P. H. Seeberger, K. Pagel. The Influence of the Electron Density in Acyl Protecting Groups on the Selectivity of Galactose Formation. J. Am. Chem. Soc. 2022, 144, 20258-20266. Link
M.-H. Lin, Chun-Wei Chang, T.-Y. Chiang, V. M. Dhurandhare, C.-C. Wang. Thiocarbonyl as a Switchable Relay-Auxiliary Group in Carbohydrate Synthesis. Org. Lett. 2021, 23, 7313−7318. (cover page) Link
K. H. Asressu, Chun-Wei Chang, S. Lam, C.-C. Wang. Donor-Reactivity-Controlled Sialylation Reactions. Eur. J. Org. Chem. 2021, 4525-4530. (cover page) Link
A. A. Joseph, V. M. Dhurandhare, Chun-Wei Chang, V. P. Verma, G. P. Mishra, C.-C. Ku, C.-C. Lin, C.-C. Wang. Chemoselective Per-O-trimethylsilylation and Homogeneous N-Functionalisation of Amino Sugars. Chem. Commun. 2015, 51, 104-106. Link
A. A. Joseph, Chun-Wei Chang, C.-C. Wang. Simple One-pot Regioselective 6-O-Phosphorylation of Carbohydrates and Trehalose Desymmetrization. Chem. Commun. 2013, 49, 11497-11499. Link
Y.-F. Yen, S. S. Kulkarni, Chun-Wei Chang, S.-Y. Luo. Concise Synthesis of alpha-Galactosyl Ceramide from D-Galactosyl Iodide and D-Lyxose. Carbohydr. Res. 2013, 368, 35-39. Link
Chapter of Publication
M. Saffertha, Ł. Polewski, Chun-Wei Chang, K. Greis, K. Pagel. In Glycoprotein Analysis. Cold-ion Spectroscopy of Carbohydrates. Struwe, W. B., Ed.. Royal Society of Chemistry Book chapter 4: 2024; 15, 0. Link
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