Publications

Dr. Chandra's research has made a significant impact in the field of pulmonary medicine, with over 4,000 citations, an h-index of 27, and an i10-index of 53, demonstrating that 53 of his papers have been cited at least 10 times. 

Original peer-reviewed articles 

1.    Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol. 2007 Sep; 37(3):273-90. PMC: 1994232.

2.     Chandra D, Guntupalli KK, Guleria R. Hypotension is a predictor of mortality in acute exacerbations of chronic obstructive pulmonary disease.  Indian J Chest Dis Allied Sci. 2007 Jan-Mar; 49(1):13-8.

3.     Chandra D, Rose SR, Carter RB, Musher DM, Hamill RJ. Fluid-containing emphysematous bullae: A spectrum of illness.  Eur Respir J. 2008 Aug; 32(2):303-6. PMID: 18669786.

4.     Chandra D, Parisini E, Mozaffarian D. Meta-analysis: Travel and risk for venous thromboembolism. Ann Intern Med. 2009 Aug 4; 151(3):180-90. Epub 2009 Jul 6.  PMID: 19581633.

5.     Chandra D, Tsai CL, Camargo CA Jr. Acute exacerbations of COPD: Delay in presentation and the risk of hospitalization.  COPD. 2009 Apr; 6(2):95-103. PMID: 19378222.

6.     Chandra D, Clark S, Camargo CA Jr. Race/Ethnicity differences in the inpatient management of acute asthma in the United States.  Chest. 2009 Jun; 135(6):1527-34. PMID: 19188553.

7.     Chandra D, Guleria R. Effect of seasonal variation on hospitalizations for acute exacerbations of chronic obstructive pulmonary disease.  Indian J Chest Dis Allied Sci. 2009 Jul-Sept; 51(3):139-43.

8.     Dodwell ER, Latorre JG, Parisini E, Zwettler E, Chandra D, Mulpuri K, Snyder B. NSAID exposure and risk of nonunion: a meta-analysis of case-control and cohort studies.  Calcif Tissue Int. 2010 Sep; 87(3):193-202. PMID: 20552333.

9.     Chandra D, Lipson DA, Hoffman EA, Hansen-Flaschen J, Sciurba FC, Decamp MM, Reilly JJ, Washko GR; National Emphysema Treatment Trial Research Group. Perfusion scintigraphy and patient selection for lung volume reduction surgery.  Am J Respir Crit Care Med. 2010 Oct 1; 182(7):937-46. PMC: 2970864.

10.  Ernst A, Simoff M, Ost D, Michaud G, Chandra D, Herth FJ. A multicenter, prospective, advanced diagnostic bronchoscopy outcomes registry.  Chest. 2010 Jul; 138(1):165-70.  PMID: 20363846.

11.  Puhan MA, Chandra D, Mosenifar Z, Ries A, Make B, Hansel NN, Wise RA, Sciurba F; National Emphysema Treatment Trial (NETT) Research Group. The minimal important difference of exercise tests in severe COPD.  Eur Respir J. 2011 Apr; 37(4):784-90. PMID: 20693247.

12.  Chandra D, Stamm JA, Taylor B, Ramos RM, Satterwhite L, Krishnan JA, Mannino D, Sciurba FC, Holguin F. Outcomes of non-invasive ventilation for acute exacerbations of COPD in the United States, 1998-2008.  Am J Respir Crit Care Med. 2012; 185(2):152-159. PMC: 3297087.

13.  Chandra D, Wise RA, Kulkarni HS, Benzo RP, Criner G, Make B, Slivka WA, Ries AL, Reilly JJ, Martinez FJ, Sciurba FC, for the NETT Research Group.  Optimizing the six minute walk test as a measure of exercise capacity in COPD.  Chest. 2012; 142(6):1545-52.   PMC: 3515028. 

14.  Chandra D,  Stamm J,  Palevsk P,  Leader J  Fuhrman C, Zhang Y, Bon J, Duncan S, Branch R, Weissfeld J, Gur D, Gladwin M, Sciurba FC. The relationship between pulmonary emphysema and kidney function in smokers.  Chest. 2012; 142:655-662. PMC: 3435137.

15.  Chandra D, Coleman JM, D Herzao-Maya J. MUC5B and pulmonary fibrosis, omalizumab for severe allergic asthma, and interstitial lung abnormalities in smokers with emphysema.  Am J Respir Crit Care Med. 2012 May 1; 185(9):1021-2. PMID: 22550211.

16.  Chandra S, Sarkar P, Chandra D, Ginsberg N, Cohen R. Finding an alternative diagnosis does not justify increased usage of CT-pulmonary angiography.  BMC Pulmonary Medicine.  2013; 13:9. PMC: 3570493.

17.  Vuga LJ, Tedrow JR, Pandit KV, Tan J, Kass DJ, Xue J, Chandra D, Leader JK, Gibson KF, Kaminski N, Sciurba FC, Duncan SR.  C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis.  Am J Respir Crit Care Med. 2014 Apr 15; 189(8):966-74. PMC: 4098096.

18.   Bon J, Kahloon R, Zhang Y, Xue J, Fuhrman CR, Tan J, Burger M, Kass DJ, Csizmadia E, Otterbein L, Chandra D, Bhargava A, Pilewski JM, Roodman GD, Sciurba FC, Duncan SR. Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers. PLoS One. 2014 Sep 12;9(9). PMC: 4162538.

19.  Liao SG, Lin Y, Kang DD, Chandra D, Bon J, Kaminski N, Sciurba FC, Tseng GC.  Missing value imputation in high-dimensional phenomic data:  Imputable or not, and how?  BMC Bioinformatics 2014; 15:346. PMC: 4228077.

20.  Chandra D, Gupta A, Strollo PJ Jr, Fuhrman CR, Leader JK, Bon J, Slivka WA,Shoushtari AH, Avolio J, Kip KE, Reis S, Sciurba FC. Airflow Limitation and Endothelial Dysfunction. Unrelated and Independent Predictors of Atherosclerosis. Am J Respir Crit Care Med. 2016 Jul 1;194(1):38-47. PubMed PMID: 26771278; PubMed Central PMCID: PMC4960631.

21.  Chandra D, Palevsky P, Sciurba FC. EnRAGEed Kidneys in Chronic Obstructive Pulmonary Disease? Am J Respir Crit Care Med. 2017 Jun 1;195(11):1411-1413. PubMed PMID: 28569576.

22.  Chandra D, Gupta A, Leader JK, Fitzpatrick M, Kingsley LA, Kleerup E, Haberlen SA, Budoff MJ, Witt M, Post WS, Sciurba FC, Morris A. Assessment of coronary artery calcium by chest CT compared with EKG-gated cardiac CT in the multicenter AIDS cohort study. PLoS One. 2017 Apr 28;12(4).  PubMed PMID: 28453572; PMCID: PMC5409142.

23.  Grace J, Leader JK, Nouraie SM, Pu J, Chandra D, Zhang Y, Sciurba FC, Bon J. Mediastinal and subcutaneous chest fat are differentially associated with emphysema progression and clinical outcomes in smokers. Respiration. 2017 Sep 15. PMID: 28910816

24.  Bon J, Zhang Y, Leader JK, Fuhrman C, Perera S, Chandra D, Bertolet M, Diergaarde B, Greenspan SL, Sciurba FC. Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. Ann Am Thorac Soc. 2018 May;15(5):615-621. PMID: 29328885.

25.  Sedgewick AJ, Buschur K, Shi I, Ramsey JD, Raghu VK, Manatakis DV, Zhang Y,Bon J, Chandra D, Karoleski C, Sciurba FC, Spirtes P, Glymour C, Benos PV. Mixed Graphical Models for Integrative Causal Analysis with Application to Chronic Lung Disease Diagnosis and Prognosis. Bioinformatics. 2018 Sep 5. doi:10.1093/bioinformatics/bty769. PubMed PMID: 30192904.

26.  Marchetti N, Kaufman T, Chandra D, Herth FJ, Shah PL, Slebos DJ, Dass C, Bicknell S, Blaas SH, Pfeifer M, Stanzell F, Witt C, Deslee G, Gesierich W, Hetzel M, Kessler R, Leroy S, Hetzel J, Sciurba FC, Criner GJ. Endobronchial Coils Versus Lung Volume Reduction Surgery or Medical Therapy for Treatment of Advanced Homogenous Emphysema. Chronic Obstr Pulm Dis. 2018 Apr 1;5(2):87-96. PubMed PMID: 30374446; PubMed Central PMCID: PMC6190523

27.  Ajala O, Zhang Y, Gupta A, Bon J, Sciurba F, Chandra D. Decreased serum TRAIL is associated with increased mortality in smokers with comorbid emphysema and coronary artery disease. Respir Med. 2018 Dec;145:21-27. PubMed PMID: 30509711.

28.  Chandra D, Londino J, Alexander S, Bednash JS, Zhang Y, Friedlander RM, Daskivich G, Carlisle DL, Lariviere WR, Nakassa ACI, Ross M, St Croix C, Nyunoya T, Sciurba F, Chen B, Mallampalli RK. The SCFFBXO3 ubiquitin E3 ligase regulates inflammation in atherosclerosis. J Mol Cell Cardiol. 2018 Nov 16;126:50-59. PubMed PMID: 30448480.

29.   Voic H, Li X, Jang JH, Zou C, Sundd P, Alder J, Rojas M, Chandra D, Randell S, Mallampalli RK, Tesfaigzi Y, Ryba T, Nyunoya T. RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia. BMC Genomics. 2019 Jan 9;20(1):22. PubMed PMID: 30626320; PubMed Central PMCID: PMC6325884.

30.   Chandra D, Gupta A, Fitzpatrick M, Haberlen SA, Neupane M, Leader JK, Kingsley LA, Kleerup E, Budoff MJ, Witt M, Sciurba FC, Post WS, Morris A. Lung Function, Coronary Artery Disease, and Mortality in HIV. Ann Am Thorac Soc. 2019 Jun;16(6):687-697 PubMed PMID: 31113229; PubMed Central PMCID: PMC6543472.

31.  Robertson T, Nouraie M, Qin S, Crothers KA, Kessinger CJ, McMahon D, Chandra D, Kingsley LA, Greenblatt RM, Huang L, Fitzpatrick ME, Morris A. HIV infection is an independent risk factor for decreased 6-minute walk test distance. PloS One. 2019 Apr 24;14(4): 2019. PubMed PMID: 31017909; PubMed Central PMCID: PMC6481785.

32.  O'Brien ME, Chandra D, Wilson RC, Karoleski CM, Fuhrman CR, Leader JK, Pu J, Zhang Y, Morris A, Nouraie S, Bon J, Urban Z, Sciurba FC. Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers. Respir Res. 2019 Jun 24;20(1):128. PubMed PMID: 31234847; PubMed Central PMCID: PMC6591816.

33.  Mallampalli RK, Li X, Jang JH, Kaminski T, Hoji A, Coon T, Chandra D, Welty S, Teng Y, Sembrat J, Rojas M, Zhao Y, Lafyatis R, Zou C, Sciurba F, Sundd P, Lan L, Nyunoya T. Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema. JCI Insight. 2020 Jan 30;5(2):e125895. PMID: 31996486

34.   Tran-Nguyen TK, * Chandra D, * Yuan K, Patibandla PK, Nguyen KT, Sethu P, Zhang Y, Xue J, Mobley JA, Kim YI, Shoushtari A, Leader JK, Bon J, Sciurba FC, Duncan SR. Glucose-Regulated Protein 78 Autoantibodies Are Associated with Carotid Atherosclerosis in Chronic Obstructive Pulmonary Disease Patients. Immunohorizons. 2020 Feb 21;4(2):108-118. PMID: 32086320.

* shared first authorship.

35.  Zhang Y, Tedrow J, Nouraie M, Li X, Chandra D, Bon J, Kass DJ, Fuhrman CR, Leader JK, Duncan SR, Kaminski N, Sciurba FC. Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers. Thorax. 2021 Apr;76(4):335-342. PMID: 33479043.

36.  Li X, Noell G, Tabib T, Gregory AD, Trejo Bittar HE, Vats R, Kaminski TW, Sembrat J, Snyder ME, Chandra D, Chen K, Zou C, Zhang Y, Sundd P, McDyer JF, Sciurba F, Rojas M, Lafyatis R, Shapiro SD, Faner R, Nyunoya T. Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD. Respir Res. 2021 Apr 6;22(1):100. PMID: 33823868; PMCID: PMC8022543.

37.  Chandra D, Gupta A, Kinney GL, Fuhrman CR, Leader JK, Diaz AA, Bon J, Barr RG, Washko G, Budoff M, Hokanson J, and Sciurba FC. The Association between Lung Hyperinflation and Coronary Artery Disease in Smokers. Chest. 2021 Sep;160(3):858-871. PMID: 33971144

38.  Gorgone M, Singhvi D, Mehdi Nouraie S, Finkelman M, Zhang Y, Pu J, Chandra D, Zhang Y, Kitsios GD, Morris A, Sciurba FC, Bon J. Circulating 1,3-Beta-D-Glucan is Associated with Lung Function, Respiratory Symptoms, and Mediators of Matrix Degradation in Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2022 May 11. PMID: 35550241.

39.  Maloy A, Alexander S, Andreas A, Nyunoya T, Chandra D. Stain-Free total-protein normalization enhances the reproducibility of Western blot data. Anal Biochem 2022 Oct 1;654:114840. PMID 35931182.

40.  Andreas A, Maloy A, Nyunoya T, Zhang Y, Chandra D. The FoxP1 gene regulates lung function, production of matrix metalloproteinases and inflammatory mediators, and viability of lung epithelia. Respir Res. 2022 Oct 11;23(1):281. PMID: 36221131.

41.  Das A, Wang X, Wei J, Hoji A, Coon TA, Popescu I, Brown M, Frizzell S, Iasella CJ, Noda K, Sembrat JC, Devonshire K, Hannan SJ, Snyder ME, Pilewski JM, Sanchez PG, Chandra D, Mallampalli RK, Alder JK, Chen BB, McDyer JF. Cross- Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection. J Immunol. 2022 Nov 1;209(9):1788-1795. PMID: 36113884; PMCID: PMC9588753.

42.  Chandra D, Bogdanoff RF, Bowler RP, Benam KH. Electronic Cigarette Menthol Flavoring is Associated with Increased Inhaled Micro and Sub-micron Particles and Worse Lung Function. Respir Res. 2023, Mar 28th Respir Res. 2023 Apr 11;24(1):108. PMID: 37038183

43.   Pu J, Leme AS, de Lima e Silva C, Beeche C, Nyunoya, Königshoff M, Chandra D. Deep-Masker: A Deep Learning-Based Tool to Assess Chord Length from Murine Lung Images. AJRCMB, 2023 Mar 15th, 2023 Aug;69(2):126-134. PMID: 37236629

44.  Tanimura K, Nouraie SM, Chandra D, Nyunoya T. Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure. J Int Med Res. 2023 Jun;51(6). PMID: 37340719

45.  Li X, Lakshmi SP, Uemasu K, Lane Z, Reddy RT, Chandra D, Zou C, Jiang Y, Nyunoya T. FBXL19 Targeted STK11 Degradation Enhances Cigarette Smoke-Induced Airway Epithelial Cell Cytotoxicity. COPD. 2024 Dec;21(1). PMID: 38712759; PMCID: PMC11186665.

46.  Allbright K, Villandre J, Crotty Alexander LE, Zhang M, Benam KH, Evankovich J, Königshoff M, Chandra D. The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes. Eur Respir J. 2024 Jun 28;63(6). PMID: 38609098.

47.  Zhang MS, Nee T, Lynch M, Rose JJ, Morris A, Chandra D. Disproportionate Use of the ED by Patients 3 Years After e-Cigarette or Vaping Use-Associated Lung Injury. Chest. 2024 Aug;166(2):339-342. PMID: 38387649; PMCID: PMC11317811.