Recent Research

Our laboratory focuses on developing CRISPR-Cas Technologies and Synthetic Bacteriophages to advance the next generation of microbial biotechnology. Through the establishment of single-nucleotide–resolution genome editing and CRISPR interference (CRISPRi) systems, we achieve precise regulation of microbial functions, while engineering programmable synthetic phages that selectively recognize and eliminate target bacteria. By integrating these approaches with Metabolic Engineering, we construct microbial cell factories that efficiently produce high-value biomolecules and exhibit enhanced performance. Furthermore, our studies on Microbial Adaptation reveal key mechanisms of genetic and metabolic flexibility, enabling the design of robust microbial platforms. Moving forward, our laboratory aims to pioneer a new era of microbial biotechnology by uniting CRISPR-Cas and bacteriophage systems to create programmable and sustainable microbial solutions that generate new scientific and industrial value.