Frailty Assessment Unit

Frailty is a complex clinical entity characterized by increased physiological vulnerability, reduced resilience to stressors and a progressive loss of physiological functions. It is associated with a significantly higher risk of hospitalization and mortality. In cardiac patients, our meta-analyses have shown that frailty increases the risk of mortality in patients undergoing percutaneous coronary intervention, those with heart failure, and in advanced heart failure patients undergoing Left Ventricular Assist Device (LVAD) implantation.

Publications:

1. Ju, C., Zhou, J., Lee, S., Tan, M.S., Liu, T., Bazoukis, G., Jeevaratnam, K., Chan, E.W.Y., Wong, I.C.K., Wei, L., Zhang, Q.*, Tse, G.* (2021) Derivation of an electronic frailty index for predicting short-term mortality in heart failure: a machine learning approach. ESC Heart Failure. PMID: 34080784. https://doi.org/10.1002/ehf2.13358. Impact factor: 4.4.

2. Sun, Y., Wang, N., Zhang, Y., Yang, J., Tse, G.*, Liu, Y.* (2021) Predictive value of H2FPEF score in patients with heart failure with preserved ejection fraction. ESC Heart Failure. 8(2):1244-1252. PMID: 33403825. https://doi.org/10.1002/ehf2.13187. Impact factor: 4.4.

3. Tse, G., Zhou, J., Woo, S.W.D., Ko, C.H., Lai, R.W.C., Liu, T., Liu, Y., Leung, K.S.K., Li, A., Lee, S., Li, K.H.C., Lakhani, I., Zhang, Q. (2020) Multi-modality machine-learning approach for risk stratification in heart failure with left ventricular ejection fraction ≤ 45%. ESC Heart Failure. 7(6):3716-25. PMID: 33094925. https://doi.org/10.1002/ehf2.12929. Impact factor: 4.4.

4. Wang, Y., Xiao, G., Zhang, G., Wang, B., Lin, Z., Saiwha, H.D., You, H., Lai, K., Su, M., Wen, H., Wang, J., Annest, L., Tse, G. (2020) Early Results of the Revivent TC Procedure for Treatment of Left Ventricular Aneurysm and Heart Failure Due to Ischemic Cardiomyopathy. EuroIntervention. 2020 Jan 28:EIJ-D-19-00225. PMID: 31985453. https://doi.org/10.4244/eij-d-19-00225. 5-year impact factor: 3.8.

5. Zhang, Y., Yuan, M., Gong, M., Li, G., Liu, T., Tse, G. (2018) Letter to the Editor: Associations between prefrailty or frailty components and clinical outcomes in heart failure: a follow-up meta-analysis. Journal of the American Medical Directors Association. pii: S1525-8610(18)30609-1. PMID: 30541690. https://doi.org/10.1016/j.jamda.2018.10.029. 5-year impact factor: 6.3.

6. Zhang, Y., Yuan, M., Gong, M., Tse, G., Li, G., Liu, T. (2018) Frailty and clinical outcomes in heart failure: a systematic review with meta-analysis. Journal of the American Medical Directors Association. S1525-8610(18)30329-3. PMID: 30076123. https://doi.org/10.1016/j.jamda.2018.06.009. 5-year impact factor: 6.3.

7. Tse, G.*, Gong, M., Wong, S.H., Wu, W.K.K., Bazoukis, G., Lampropoulos, K., Wong, W.T., Xia, Y., Wong, M.C.S., Liu, T., Woo, J. (2017) Frailty and clinical outcomes in advanced heart failure patients undergoing left ventricular assist device implantation: a systematic review and meta-analysis. Journal of the American Medical Directors Association. pii: S1525-8610(17)30545-5. PMID: 29129497.http://dx.doi.org/10.1016/j.jamda.2017.09.022. Impact factor: 5.