The Hong Kong Disease Modelling Laboratory

The Hong Kong Disease Modelling Laboratory was established in 2018. It is at the forefront of disease modelling and developing state-of-the-art, artificial intelligence-enhanced, Chinese-specific predictive risk models. We use a big data approach, capturing multidimensional data from routinely collected electronic health records (eHR) for accurate predictions.

Our cross-functional team develop AI models that can be implemented into eHR systems and simpler web-based calculators for ease of use at the bedside or in the community. A summary of our developed models is shown below:

Tse G, Lee Q, Chou OHI, Chung CT, Lee S, Chan JSK, Li G, Kaur N, Roever L, Liu H, Liu T, Zhou J. Healthcare Big Data in Hong Kong: development and implementation of artificial intelligence-enhanced predictive models for risk stratification. Curr Probl Cardiol. 2023 Oct 21:102168. doi: 10.1016/j.cpcardiol.2023.102168. Epub ahead of print. PMID: 37871712.

PowerAI-CVD (2023) and ChineseCVD (2023)

PowerAI-CVD (2023) is the first-in-world, Chinese-specific, AI-driven, comprehensive predictive model incorporating physiological BP measurements, disease status, medications and laboratory tests for 10-year CVD risk.

ChineseCVD (2023) is first-in-world, web-based, Chinese-specific Cardiovascular Risk Calculator incorporating long COVID, COVID-19 vaccination, SGLT2i and PCSK9i treatment effects

PowerAI-Diabetes (2021)

PowerAI-Diabetes (2021) is the third-in-world, Chinese-specific AI-driven predictive model for predicting diabetic complications. Our team was also first-in-world to incorporate lipid and glycemic variability into an AI-driven predictive model, using random survival forest.

PowerAI-DM-Fractures (2023)

PowerAI-DM-Fractures (2023) is our machine learning-based in-silico marker to predict new onset composite of hip and vertebral fractures in patients with type-2 diabetes mellitus. The model is under patent application.

PowerAI-Brugada (2021)

PowerAI-Brugada (2021) is the first in world, AI-driven, comprehensive predictive model incorporating genetics, clinical findings and ECG features for predicting ventricular arrhythmias and sudden cardiac death in Brugada syndrome.

PowerAI-LQTS (2021)

PowerAI-LQTS (2021) is the first in world, AI-driven, comprehensive predictive model incorporating genetics, clinical findings and ECG features for predicting ventricular arrhythmias and sudden cardiac death in long QT syndrome.

Collaborating Institutions