Epidemiology Research Unit

Lead: Sharen Lee, Martin Tan

COVID-19

The coronavirus (COVID-19) has led to a global pandemic, which has placed an overwhelming burden on healthcare, economic and social systems worldwide. Tse's team has leveraged their expertise on pharmacoepidemiology, and collaborated with local clinicians and researchers to study the risk factors, epidemiology and outcomes in COVID-19. This has led to a development of predictive risk model for forecasting severe outcomes, defined as admission to the intensive care unit, need for invasive ventilation or 30-day mortality. This model was published in Nature's npj Digital Medicine, has been translated into clinical use. The easy-to-use risk score, now available on QxMD, a subsidiary of WebMD, can serve as an accessible screening tool for the early direction of resources to these high-risk individuals and improve their prognosis.

Presentations and Output

Gary talks to the Asian Conference on Pharmacoepidemiology (ACPE 2021) on the relationship between the use of statins and adverse outcomes in COVID-19

Publications

1. Tse, G.*, Zhou, J.*, Lee, S., Wong, W.T., Li, X., Liu, T., Cao, Z., Zeng, D.D., Wai, A.K.C., Wong, I.C.K., Cheung, B.M.Y., Zhang, Q. (2021) Relationship between angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and COVID-19 incidence or severe disease. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000002866. 5-year impact factor: 4.8.

2. Zhou, J., Lee, S., Wang, X., Li, Y., Wu, W.K.K., Liu, T., Cao, Z., Zeng, D.D., Leung, K.S.K., Wai, A.K.C., Wong, I.C.K., Cheung, B.M.Y., Zhang, Q.*, Tse, G.* (2021) Development of a multivariable prediction model for severe COVID-19 disease: a population-based study from Hong Kong. NPJ Digital Medicine. https://doi.org/10.1038/s41746-021-00433-4. Impact factor: 11.7.

3. Zhou, J., Lee, S., Guo, C.L., Chang, C., Liu, T., Leung, K.S.K., Wai, A.K.C., Cheung, B.M.Y., Tse, G.*, Zhang, Q.* (2021) Anticoagulant or antiplatelet use and severe COVID-19 disease: a propensity score matched territory-wide study. Pharmacological Research. 105473. PMID: 33524539. https://doi.org/10.1016/j.phrs.2021.105473. 5-year impact factor: 7.7.

4. Zhou, J., Wang, X., Lee, S., Wu, W.K.K., Cheung, B.M.Y., Zhang, Q.*, Tse, G.* (2020) Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study. Gut. gutjnl-2020-323668. PMID: 33277346. https://doi.org/10.1136/gutjnl-2020-323668. 5-year impact factor: 17.8.

5. Li, X., Guan, B., Su, T., Liu, W., Chen, M., Bin Waleed, K., Guan, X., Tse, G.*, Zhu, Z.* Impact of cardiovascular disease and cardiac injury on in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis. (2020) Heart. 27:heartjnl-2020-317062. PMID: 32461330. https://doi.org/10.1136/heartjnl-2020-317062. 5-year impact factor: 5.4.

6. Wang, Y., Tse, G., Li, G., Lip, G.Y.H., Liu, T. (2020) ACE Inhibitors and Angiotensin II Receptor Blockers May Have Different Impact on Prognosis of COVID-19. Journal of the American College of Cardiology. 76(17):2041. PMID: 33092742. https://doi.org/10.1016/j.jacc.2020.07.068. 5-year impact factor: 19.0.

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