1. Yang Y, Jiang J, Takahashi K, Tanaka N, Kosugi K, Ono A, Kozawa J, Katakami N, Fukuhara A, Maeda N, Shimomura I, Shimizu Y: Stigma and healthcare professional support among adults with diabetes in Japan: A cross-sectional study. Jpn J Nurs Sci 2026;23:e70031
2. Nakatani R, Watabe T, Fukuhara A, Takano T, Kamiya T, Sasaki H, Kurakami H, Nakata Y, Otsuki M, Hidaka Y, Shimomura I: Initial Evaluation of Radioiodine Therapy Using Imaging for Long-term Prognosis in Thyroid Cancer: A Retrospective Study. J Clin Endocrinol Metab 2026;111:1004-1020
https://resou.osaka-u.ac.jp/ja/research/2025/20251125_1
3. Watabe T, Mukai K, Naka S, Sasaki H, Kamiya T, Hayakawa T, Fukuhara A, Takano T, Shirakami Y, Ooe K, Shigeno S, Okamura S, Masumura K, Hida E, Haba H, Toyoshima A, Isohashi K, Shimomura I, Tomiyama N: First-in-Human Study of [(211)At]NaAt as Targeted alpha-Therapy in Patients with Radioiodine-Refractory Thyroid Cancer (Alpha-T1 Trial). Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2025;66:1941-1947
https://resou.osaka-u.ac.jp/ja/research/2025/20251007_1
4. Tobimatsu A, Mukai K, Obata Y, Isohashi K, Miyashita K, Fukuhara A, Kato H, Shimomura I: Potentially fatal crisis after (177)Lu-DOTATATE therapy for paraganglioma: a case report with review of literature. Endocr J 2025;72:1143-1150
5. Onishi A, Obata Y, Hayakawa T, Fujiwara M, Ohata Y, Tamura Y, Kawata S, Mukai K, Miyashita K, Yamamoto K, Kubota T, Fukuhara A, Shimomura I: A novel heterozygous frameshift pathogenic variant in GCM2 gene causing isolated hypoparathyroidism: a case report. Front Endocrinol (Lausanne) 2025;16:1589182
6. Nakano E, Mukai K, Yamamoto K, Otsuki M, Fukuhara A, Shimomura I: Adipose Composition Before and After Primary Aldosteronism Treatment Depends on Primary Aldosteronism Subtypes and Plasma Aldosterone Concentration Before the Treatment. J Clin Hypertens (Greenwich) 2025;27:e70097
7. Budzen K, Mukai K, Mitsui Y, Otsuki M, Fukuhara A, Oshino S, Saitoh Y, Kohara M, Morii E, Shimomura I: Mutual associations among responsiveness to differential diagnostic tests for Cushing's disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors. Endocr J 2025;72:93-102
8. Uota A, Okuno Y, Fukuhara A, Sasaki S, Kobayashi S, Shimomura I: ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes. J Biol Chem 2024;300:107953
https://resou.osaka-u.ac.jp/ja/research/2024/20241205_1
9. Okuno Y, Mukai K, Tamura Y, Hayakawa T, Fukuhara A, Shimomura I: Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review. Case Rep Endocrinol 2024;2024:2524019
10. Okuno Y, Fukuhara A, Shimomura I: The role of oxidative stress, glucocorticoid receptor and ARMC5 in lipid metabolism. Endocr J 2024;71:1097-1101
11. Nakano E, Mukai K, Fukuhara A, Otsuki M, Shimomura I, Ichijo T, Tsuiki M, Wada N, Yoneda T, Takeda Y, Oki K, Yamada T, Ogawa Y, Yabe D, Kakutani M, Sone M, Katabami T, Tanabe A, Naruse M, Group JJS: Primary aldosteronism patients with previous cardiovascular and cerebrovascular events have high aldosterone responsiveness to ACTH stimulation. Endocr J 2024;71:489-497
12. Mitsui Y, Mukai K, Otsuki M, Oshino S, Saitoh Y, Kohara M, Morii E, Fukuhara A, Shimomura I: Growth hormone increase by luteinizing hormone-releasing hormone reflects gonadotroph-related characteristics in acromegaly. Pituitary 2024;27:527-536
13. Shin J, Toyoda S, Okuno Y, Hayashi R, Nishitani S, Onodera T, Sakamoto H, Ito S, Kobayashi S, Nagao H, Kita S, Otsuki M, Fukuhara A, Nagata K, Shimomura I: HSP47 levels determine the degree of body adiposity. Nat Commun 2023;14:7319
https://resou.osaka-u.ac.jp/ja/research/2023/20231204_1
14. Yamamuro T, Nakamura S, Yanagawa K, Tokumura A, Kawabata T, Fukuhara A, Teranishi H, Hamasaki M, Shimomura I, Yoshimori T: Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response. Autophagy 2022;18:2686-2696
15. Toyoda S, Shin J, Fukuhara A, Otsuki M, Shimomura I: Transforming growth factor beta1 signaling links extracellular matrix remodeling to intracellular lipogenesis upon physiological feeding events. J Biol Chem 2022;298:101748
16. Shin J, Toyoda S, Nishitani S, Onodera T, Fukuda S, Kita S, Fukuhara A, Shimomura I: SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1. Metabolism 2022;133:155236
17. Shin J, Toyoda S, Fukuhara A, Shimomura I: GRP78, a Novel Host Factor for SARS-CoV-2: The Emerging Roles in COVID-19 Related to Metabolic Risk Factors. Biomedicines 2022;10:1995
18. Okuno Y, Fukuhara A, Otsuki M, Shimomura I: ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors. JCI Insight 2022;7:e151390
19. Nishitani S, Fukuhara A, Tomita I, Kume S, Shin J, Okuno Y, Otsuki M, Maegawa H, Shimomura I: Ketone body 3-hydroxybutyrate enhances adipocyte function. Sci Rep 2022;12:10080
20. Minemura T, Fukuhara A, Otsuki M, Shimomura I: Lactate dehydrogenase regulates basal glucose uptake in adipocytes. Biochem Biophys Res Commun 2022;607:20-27
21. Kobayashi S, Kita S, Okuzaki D, Fujishima Y, Otsuki M, Kato H, Nishizawa Y, Miyashita K, Yokoyama C, Fukuhara A, Morii E, Shimomura I: Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway. iScience 2022;25:105252
http://resou.osaka-u.ac.jp/ja/research/2018/20180409_1
22. Shin J, Toyoda S, Nishitani S, Fukuhara A, Kita S, Otsuki M, Shimomura I: Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19. Diabetes 2021;70:2745-2755
23. Okuro K, Fukuhara A, Minemura T, Hayakawa T, Nishitani S, Okuno Y, Otsuki M, Shimomura I: Glutamine deficiency induces lipolysis in adipocytes. Biochem Biophys Res Commun 2021;585:155-161
24. Hayakawa T, Fukuhara A, Saiki A, Otsuki M, Shimomura I: gammaENaC/CD9 in urinary extracellular vesicles as a potential biomarker of MR activity. J Endocrinol 2021;252:81-90
https://resou.osaka-u.ac.jp/ja/research/2021/20211221_2
25. Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, Fujiwara M, Enokidani Y, Yoshida G, Tabata K, Hamasaki M, Kuma A, Yamamoto K, Shimomura I, Yoshimori T: Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat Commun 2020;11:4150
26. Nishitani S, Fukuhara A, Jinno Y, Kawano H, Yano T, Otsuki M, Shimomura I: Metabolomic Analysis of Diet-Induced Obese Mice Supplemented with Eicosapentaenoic Acid. Exp Clin Endocrinol Diabetes 2020;128:548-555
27. Hayashi R, Okuno Y, Mukai K, Kitamura T, Hayakawa T, Onodera T, Murata M, Fukuhara A, Imamura R, Miyagawa Y, Nonomura N, Otsuki M, Shimomura I: Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome. Endocrinology 2019;160:504-521
https://resou.osaka-u.ac.jp/ja/research/2019/20190228_1
28. Shin J, Fukuhara A, Onodera T, Kita S, Yokoyama C, Otsuki M, Shimomura I: SDF-1 Is an Autocrine Insulin-Desensitizing Factor in Adipocytes. Diabetes 2018;67:1068-1078
http://resou.osaka-u.ac.jp/ja/research/2018/20180409_1
29. Okuno Y, Fukuhara A, Hashimoto E, Kobayashi H, Kobayashi S, Otsuki M, Shimomura I: Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway. Diabetes 2018;67:1113-1127
http://resou.osaka-u.ac.jp/ja/research/2018/20180410_1
30. Nishitani S, Fukuhara A, Shin J, Okuno Y, Otsuki M, Shimomura I: Metabolomic and microarray analyses of adipose tissue of dapagliflozin-treated mice, and effects of 3-hydroxybutyrate on induction of adiponectin in adipocytes. Sci Rep 2018;8:8805
31. Kamura K, Shin J, Kiyonari H, Abe T, Shioi G, Fukuhara A, Sasaki H: Obesity in Yap transgenic mice is associated with TAZ downregulation. Biochem Biophys Res Commun 2018;505:951-957
32. Hayakawa T, Minemura T, Onodera T, Shin J, Okuno Y, Fukuhara A, Otsuki M, Shimomura I: Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity. J Endocrinol 2018;239:63-71
33. Chijimatsu R, Kobayashi M, Ebina K, Iwahashi T, Okuno Y, Hirao M, Fukuhara A, Nakamura N, Yoshikawa H: Impact of dexamethasone concentration on cartilage tissue formation from human synovial derived stem cells in vitro. Cytotechnology 2018;70:819-829
34. Shin J, Fukuhara A, Onodera T, Yokoyama C, Otsuki M, Shimomura I: Regulation of Dipeptidyl Peptidase-4, its Substrate Chemokines, and Their Receptors in Adipose Tissue of ob/ob Mice. Horm Metab Res 2017;49:380-387
35. Onodera T, Fukuhara A, Shin J, Hayakawa T, Otsuki M, Shimomura I: Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice. Sci Rep 2017;7:4560
36. Tabuchi Y, Kitamura T, Fukuhara A, Mukai K, Onodera T, Miyata Y, Hamasaki T, Oshino S, Saitoh Y, Morii E, Otsuki M, Shimomura I: Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing's disease and subclinical Cushing's disease. Endocr J 2016;63:545-554
37. Onodera T, Fukuhara A, Jang MH, Shin J, Aoi K, Kikuta J, Otsuki M, Ishii M, Shimomura I: Adipose tissue macrophages induce PPARgamma-high FOXP3(+) regulatory T cells. Sci Rep 2015;5:16801
38. Kuroda Y, Iwahashi H, Mineo I, Fukui K, Fukuhara A, Iwamoto R, Imagawa A, Shimomura I: Hyperinsulinemic hypoglycemia syndrome associated with mutations in the human insulin receptor gene: report of two cases. Endocr J 2015;62:353-362
39. Kobayashi S, Fukuhara A, Otsuki M, Suganami T, Ogawa Y, Morii E, Shimomura I: Fat/vessel-derived secretory protein (Favine)/CCDC3 is involved in lipid accumulation. J Biol Chem 2015;290:7443-7451
40. Tamada D, Kitamura T, Onodera T, Tabuchi Y, Fukuhara A, Oshino S, Saitoh Y, Hamasaki T, Otsuki M, Shimomura I: Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery. Endocr J 2014;61:231-237
41. Lin H, Maeda K, Fukuhara A, Shimomura I, Ito T: Molecular expression of adiponectin in human saliva. Biochem Biophys Res Commun 2014;445:294-298
42. Miyata Y, Fukuhara A, Otsuki M, Shimomura I: Expression of activating transcription factor 2 in inflammatory macrophages in obese adipose tissue. Obesity (Silver Spring) 2013;21:731-736
43. Hu D, Fukuhara A, Miyata Y, Yokoyama C, Otsuki M, Kihara S, Shimomura I: Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway. PLoS One 2013;8:e56071
44. Tanaka M, Fukuhara A, Shimomura I: N-linked glycosylation of mouse adiponectin. Horm Metab Res 2011;43:545-550
45. Okuno Y, Matsuda M, Miyata Y, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I: Human catalase gene is regulated by peroxisome proliferator activated receptor-gamma through a response element distinct from that of mouse. Endocr J 2010;57:303-309
46. Kobayashi S, Fukuhara A, Taguchi T, Matsuda M, Tochino Y, Otsuki M, Shimomura I: Identification of a new secretory factor, CCDC3/Favine, in adipocytes and endothelial cells. Biochem Biophys Res Commun 2010;392:29-35
47. Inomata-Kurashiki Y, Maeda K, Yoshioka E, Fukuhara A, Imagawa A, Otsuki M, Shimomura I: Measurement of adiponectin production from differentiated metabolic stem cells. Horm Metab Res 2010;42:318-323
48. Tanabe A, Matsuda M, Fukuhara A, Miyata Y, Komuro R, Shimomura I, Tojo H: Obesity causes a shift in metabolic flow of gangliosides in adipose tissues. Biochem Biophys Res Commun 2009;379:547-552
49. Segawa K, Matsuda M, Fukuhara A, Morita K, Okuno Y, Komuro R, Shimomura I: Identification of a novel distal enhancer in human adiponectin gene. J Endocrinol 2009;200:107-116
50. Saisho K, Fukuhara A, Yasuda T, Sato Y, Fukui K, Iwahashi H, Imagawa A, Hatta M, Shimomura I, Yamagata K: Glucose enhances collectrin protein expression in insulin-producing MIN6 beta cells. Biochem Biophys Res Commun 2009;389:133-137
51. Nakayama Y, Komuro R, Yamamoto A, Miyata Y, Tanaka M, Matsuda M, Fukuhara A, Shimomura I: RhoA induces expression of inflammatory cytokine in adipocytes. Biochem Biophys Res Commun 2009;379:288-292
52. Kobayashi H, Matsuda M, Fukuhara A, Komuro R, Shimomura I: Dysregulated glutathione metabolism links to impaired insulin action in adipocytes. Am J Physiol Endocrinol Metab 2009;296:E1326-1334
53. Ebina K, Oshima K, Matsuda M, Fukuhara A, Maeda K, Kihara S, Hashimoto J, Ochi T, Banda NK, Yoshikawa H, Shimomura I: Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice. Biochem Biophys Res Commun 2009;378:186-191
54. Ebina K, Fukuhara A, Ando W, Hirao M, Koga T, Oshima K, Matsuda M, Maeda K, Nakamura T, Ochi T, Shimomura I, Yoshikawa H, Hashimoto J: Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction. Clin Rheumatol 2009;28:445-451
55. Takagi T, Matsuda M, Abe M, Kobayashi H, Fukuhara A, Komuro R, Kihara S, Caslake MJ, McMahon A, Shepherd J, Funahashi T, Shimomura I: Effect of pravastatin on the development of diabetes and adiponectin production. Atherosclerosis 2008;196:114-121
56. Okuno Y, Matsuda M, Kobayashi H, Morita K, Suzuki E, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I: Adipose expression of catalase is regulated via a novel remote PPARgamma-responsive region. Biochem Biophys Res Commun 2008;366:698-704
57. Nishihara T, Baba M, Matsuda M, Inoue M, Nishizawa Y, Fukuhara A, Araki H, Kihara S, Funahashi T, Tamura S, Hayashi N, Iishi H, Shimomura I: Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. World J Gastroenterol 2008;14:6473-6480
58. Miyata Y, Fukuhara A, Matsuda M, Komuro R, Shimomura I: Insulin induces chaperone and CHOP gene expressions in adipocytes. Biochem Biophys Res Commun 2008;365:826-832
59. Araki H, Nishihara T, Matsuda M, Fukuhara A, Kihara S, Funahashi T, Kataoka TR, Kamada Y, Kiyohara T, Tamura S, Hayashi N, Shimomura I: Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet. Gut 2008;57:1431-1440
60. Abe M, Matsuda M, Kobayashi H, Miyata Y, Nakayama Y, Komuro R, Fukuhara A, Shimomura I: Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages. Arterioscler Thromb Vasc Biol 2008;28:871-877
61. Nozaki M, Fukuhara A, Segawa K, Okuno Y, Abe M, Hosogai N, Matsuda M, Komuro R, Shimomura I: Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2007;364:33-39
62. Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, Shimomura I: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007;56:901-911
63. Yamada A, Irie K, Hirota T, Ooshio T, Fukuhara A, Takai Y: Involvement of the annexin II-S100A10 complex in the formation of E-cadherin-based adherens junctions in Madin-Darby canine kidney cells. J Biol Chem 2005;280:6016-6027
64. Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J, Yoshikawa H, Shimomura I: Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005;331:520-526
65. Okamoto R, Irie K, Yamada A, Katata T, Fukuhara A, Takai Y: Recruitment of E-cadherin associated with alpha- and beta-catenins and p120ctn to the nectin-based cell-cell adhesion sites by the action of 12-O-tetradecanoylphorbol-13-acetate in MDCK cells. Genes Cells 2005;10:435-445
66. Yamada A, Irie K, Fukuhara A, Ooshio T, Takai Y: Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells. Genes Cells 2004;9:843-855
67. Ooshio T, Irie K, Morimoto K, Fukuhara A, Imai T, Takai Y: Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. J Biol Chem 2004;279:31365-31373
68. Kitazawa H, Nishihara T, Nambu T, Nishizawa H, Iwaki M, Fukuhara A, Kitamura T, Matsuda M, Shimomura I: Intectin, a novel small intestine-specific glycosylphosphatidylinositol-anchored protein, accelerates apoptosis of intestinal epithelial cells. J Biol Chem 2004;279:42867-42874
69. Katata T, Irie K, Fukuhara A, Kawakatsu T, Yamada A, Shimizu K, Takai Y: Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells. Oncogene 2003;22:2097-2109
70. Honda T, Shimizu K, Kawakatsu T, Yasumi M, Shingai T, Fukuhara A, Ozaki-Kuroda K, Irie K, Nakanishi H, Takai Y: Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E-cadherin-based cell-cell adhesion. Genes Cells 2003;8:51-63
71. Honda T, Shimizu K, Fukuhara A, Irie K, Takai Y: Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions. Biochem Biophys Res Commun 2003;306:104-109
72. Fukuhara A, Shimizu K, Kawakatsu T, Fukuhara T, Takai Y: Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells. J Biol Chem 2003;278:51885-51893
73. Fukuhara A, Irie K, Yamada A, Katata T, Honda T, Shimizu K, Nakanishi H, Takai Y: Role of nectin in organization of tight junctions in epithelial cells. Genes Cells 2002;7:1059-1072
74. Fukuhara A, Irie K, Nakanishi H, Takekuni K, Kawakatsu T, Ikeda W, Yamada A, Katata T, Honda T, Sato T, Shimizu K, Ozaki H, Horiuchi H, Kita T, Takai Y: Involvement of nectin in the localization of junctional adhesion molecule at tight junctions. Oncogene 2002;21:7642-7655
75. Shinohara M, Kodama A, Matozaki T, Fukuhara A, Tachibana K, Nakanishi H, Takai Y: Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1. J Biol Chem 2001;276:18941-18946
76. Kawabe H, Nakanishi H, Asada M, Fukuhara A, Morimoto K, Takeuchi M, Takai Y: Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. J Biol Chem 2001;276:48350-48355
77. Kodama A, Matozaki T, Fukuhara A, Kikyo M, Ichihashi M, Takai Y: Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering. Mol Biol Cell 2000;11:2565-2575
78. Tsuchikane E, Fukuhara A, Kobayashi T, Kirino M, Yamasaki K, Kobayashi T, Izumi M, Otsuji S, Tateyama H, Sakurai M, Awata N: Impact of cilostazol on restenosis after percutaneous coronary balloon angioplasty. Circulation 1999;100:21-26
79. Yasuda H, Hiraishi T, Sumitsuji S, Nakagawa Y, Fukuhara A, Tsuchikane E, Katoh O, Awata N, Kobayashi T: Comparison of quantitative coronary angiographic results after directional coronary atherectomy and balloon angioplasty of protected left main coronary stenosis. Cathet Cardiovasc Diagn 1998;44:138-141
80. Tsuchikane E, Katoh O, Sumitsuji S, Fukuhara A, Funamoto M, Otsuji S, Tateyama H, Awata N, Kobayashi T: Impact of cilostazol on intimal proliferation after directional coronary atherectomy. Am Heart J 1998;135:495-502