Dr. Matteo Borgini is an assistant professor of chemistry at Augusta University, USA. He received his undergraduate and graduate training in pharmaceutical sciences at the University of Siena, Italy. He then completed postdoctoral research with Professor Peter Wipf at the University of Pittsburgh, where his work focused on synthetic methodology development, medicinal chemistry, and chemical biology. Dr. Borgini’s research program is centered on organic synthesis with an emphasis on strain-release-driven chemical transformations as enabling tools for complex molecule synthesis. In parallel, his group is actively engaged in medicinal chemistry efforts aimed at developing chemical strategies to modulate challenging biological targets. In particular, his work explores approaches to address targets traditionally considered undruggable through the design of protein–protein interaction inhibitors and covalent small-molecule therapeutics.