Publications

Binuraj R. K. Menon, 2022. A rational approach to re-engineer the catalytic efficiency of flavin-dependent halogenases, Chem Catalysis, 2(10), 2434-2437 View

Navya Menon, Daniel Richmond, Mohammad Rejaur Rahman, and Binuraj R. K. Menon, 2022. Versatile and Facile One-Pot Biosynthesis for Amides and Carboxylic Acids in E. coli by Engineering Auxin Pathways of Plant Microbiomes, ACS Catalysis 12 (4), 2309-2319 View

Menon, Binuraj R. K. 2021. The missing colours of chemistry. Nature Chemistry, 13. pp. 101-106. DOI: 10.1038/s41557-020-00632-8 View

Binuraj R. K. Menon, Daniel Richmond, Navya Menon. 2020. Halogenases for biosynthetic pathway engineering: Toward new routes to naturals and non-naturals, Catalysis Reviews, DOI: 10.1080/01614940.2020.1823788 View

Cummings, Matthew, Peters, Anna D., Whitehead, George F.S., Menon, Binuraj R.K., Micklefield, Jason, Webb, Simon J., Takano, Eriko. 2019. Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli. PLOS Biology, View

Menon, Binuraj R. K., Jenner, Matthew. 2018. Biosynthesis : reprogramming assembly lines. Nature Chemistry, 10 (3), pp. 245-247, View

Bennett, Matthew R., Thompson, Mark L., Shepherd, Sarah A., Dunstan, Mark S., Herbert, Abigail J., Smith, Duncan R. M., Cronin, Victoria A., Menon, Binuraj R. K., Levy, Colin, Micklefield, Jason. 2018.. Angewandte Chemie International Edition, View

Menon, Binuraj R. K., Brandenburger, Eileen, Sharif, Humera H., Klemstein, Ulrike, Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason. 2017. RadH : a versatile halogenase for integration into synthetic pathways. Angewandte Chemie International Edition, 56 (39), pp. 11841-11845, View

Latham, Jonathan, Brandenburger, Eileen, Shepherd, Sarah A., Menon, Binuraj R. K., Micklefield, Jason. 2017. Development of halogenase enzymes for use in synthesis. Chemical Reviews, View

Latham, Jonathan, Henry, Jean-Marc, Sharif, Humera H., Menon, Binuraj R. K., Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason. 2016. Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation. Nature Communications, 7, View

Menon, Binuraj R. K., Latham, Jonathan, Dunstan, Mark S., Brandenburger, Eileen, Klemstein, Ulrike, Leys, David, Karthikeyan, Chinnan, Greaney, Michael F., Shepherd, Sarah A., Micklefield, Jason. 2016. Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes. Organic and Biomolecular Chemistry, 14 (39), pp. 9354-9361, View

Menon, Binuraj R. K., Hardman, Samantha J. O., Scrutton, Nigel S., Heyes, Derren J.. 2016. Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR). Journal of Photochemistry and Photobiology B: Biology, 161, pp. 236-243, View

Shepherd, Sarah A., Menon, Binuraj R. K., Fisk, Heidi, Struck, Anna-Winona, Levy, Colin, Leys, David, Micklefield, Jason. 2016. A structure-guided switch in the regioselectivity of a tryptophan halogenase. Chembiochem, 17 (9), pp. 821-824, View

Ortmayer, Mary, Lafite, Pierre, Menon, Binuraj R. K., Tralau, Tewes, Fisher, Karl, Denkhaus, Lukas, Scrutton, Nigel S., Rigby, Stephen E. J., Munro, Andrew W., Hay, Sam, Leys, David. 2016. An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme. Nature, 539 (7630), pp. 593-597, View

Menon, Navya, Pásztor, András, Menon, Binuraj R. K., Kallio, Pauli, Fisher, Karl, Akhtar, M. Kalim, Leys, David, Jones, Patrik R., Scrutton, Nigel S. 2015. A microbial platform for renewable propane synthesis based on a fermentative butanol pathway. Biotechnology for Biofuels, 8 (1), View

Shepherd, Sarah A., Karthikeyan, Chinnan, Latham, Jonathan, Struck, Anna-Winona, Thompson, Mark L., Menon, Binuraj R. K., Styles, Matthew Q., Levy, Colin, Leys, David, Micklefield, Jason. 2015. Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes. Chemical Science, 6 (6), pp. 3454-3460, View

Menon, Binuraj R. K., Menon, Navya, Fisher, Karl, Rigby, Stephen E. J., Leys, David, Scrutton, Nigel S. 2015. Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase. FEBS Journal, 282 (7), pp. 1242-1255, View

Menon, Binuraj R. K., Fisher, Karl, Rigby, Stephen E. J., Scrutton, Nigel S., Leys, David. 2014. A conformational sampling model for radical catalysis in pyridoxal phosphate- and cobalamin-dependent enzymes. Journal of Biological Chemistry, 289 (49), pp. 34161-34174, View

Menon, Binuraj R. K., Waltho, Jonathan P., Scrutton, Nigel S., Heyes, Derren J.. 2009. Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase. Journal of Biological Chemistry, 284 (27), pp. 18160-18166, View

Menon, Binuraj R. K., Davison, Paul A., Hunter, C. Neil, Scrutton, Nigel S., Heyes, Derren J.. 2009. Mutagenesis alters the catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase. Journal of Biological Chemistry, 285 (3), pp. 2113-2119, View

Heyes, Derren J., Menon, Binuraj R. K., Sakuma, Michiyo, Scrutton, Nigel S.. 2008. Conformational events during ternary enzyme-substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase. Biochemistry, 47 (41), pp. 10991-10998, View