Metacognition : Metacognition's role in providing pain education is important as it address "what to deliver" , "when to deliver" and "how to deliver".

Pedagogy : Contemporary pedagogical methods such as one-on-one teaching, demonstrations, analogies, word pictures can be used for pain education in conditions like knee OA.

Praxis : Pain education praxis is itself an analgesic for chronic conditions like knee OA.

Axiology : The axiological program such as self management and pain education in knee OA constitutes the high value guideline based care.

Epistemology : An epistemological issue is how Physiotherapists know about the phenomena of self-management and its effects in patients with knee OA.

Ontology : Gene ontology analysis helps to identify either the knee OA is associated with the genetic predisposition or not.