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Photoacoustic Imaging
Photoacoustic Imaging
A new design of light illumination scheme for deep tissue photoacoustic imaging, a light catcher, is proposed and evaluated by in silico simulation. Finite element (FE)-based numerical simulation model was developed for photoacoustic (PA) imaging in soft tissues. Both optical and acoustical parameters in soft tissues such as scattering, absorption, and attenuation are incorporated in tissue models. PA imaging performance with different design parameters of the laser source and energy delivery scheme was investigated. The optimized parameters through this simulation will guide the design of PA system for deep tissue imaging, and help to form the base protocols of experimental evaluations in vitro and in vivo.
Figure 1. Laser illumination.
Figure 2. Propogation of photoacoustic signal .
Photoacoustic imaging was used to the diagnosis of cancer tumor on the back of mouse and scaffold implantation on the abdomen of rat.
Zhaohui Wang, Seung-Han Ha, Kang Kim, “A new design of light illumination scheme for deep tissue photoacoustic imaging,” Optics Express, 20(20), 22649-22659 (2012).
Zhaohui Wang, Seung-Han Ha, Kang Kim, "Evaluation of finite element based simulation model of photoacoustics in biological tissues," Proceedings of SPIE 8320, 83201L (2012).
Zhaohui Wang, Seung-Han Ha, Kang Kim, "Photoacoustic Design Parameter Optimization for Deep Tissue Imaging by Numerical Simulation," Proceedings of SPIE 8223, 822346 (2012).
Figure 3. Diagnosis of breast cancer tumor on the back of mouse using photoacoustic imaging
Figure 4. Diagnosis of scaffold implantation on the abdomen of rat using photoacoustic imaging
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