2003年

Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease.
Foy E, Li K, Wang C, Sumpter R Jr., Ikeda M, Lemon SM, Gale M Jr.
Science, 300(5622):1145-8 (2003)

Nonstractural protein precursor NS4A/B from hepatits C virus alters function and ultrastracture of host secretory apparatus.
Konan KV, Giddings TH Jr., Ikeda M, Li K, Lemon SM, Kirkegaard K.
J. Virol., 77(14):7843-55 (2003)

Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein.
Nozaki A, Ikeda M, Naganuma A, Nakamura T, Inudoh M, Tanaka K, Kato N.
J. Biol. Chem., 278(12):10162-73 (2003)

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.
Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach JA, Trent JO, Wang ZX, Peiper SC.
Angew Chem Int Ed Engl., 42(28):3251-3 (2003)

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.
Tamamura H, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N.
Org Biomol Chem., 1(21):3656-62 (2003)

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.
Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N.
Org Biomol Chem., 1(21):3663-9 (2003)

Cytotoxic activity of azulenes against human oral tumor cell lines.
Wakabayashi H, Hashiba K, Yokoyama K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Satoh K, Shioda S, Saito S, Kusano S, Nakashima H, Motohashi N, Sakagami H.
Anticancer Res., 23(6C):4747-55 (2003)