Key Research Projects
Our laboratory delves into the mechanisms governing cellular adaptation to various forms of metabolic stress using genetic deficiencies and pharmacological interventions targeting specific metabolic pathways. Investigating how cells adapt to alterations in extracellular metabolites or critical metabolic pathways crucial for maintaining energy metabolism could provide valuable insights into the pathophysiology of metabolic diseases. The primary research endeavors of the laboratory include Sirtuin project and p21 activated kinase 4 (PAK4) project.
Sirtuin project
Sirtuins comprise a family of signaling proteins implicated in metabolic regulation. They exhibit ancient evolutionary origins across animal species and maintain a highly conserved structure throughout various life forms. Mammals possess seven sirtuins (Sirt1 to Sirt7), each with distinct biological activities and subcellular localization. Through a combination of tissue-specific Sirt6 knockout mouse models and in vitro cellular systems, our investigations aim to elucidate the impact of Sirt6 on metabolic health and the predisposition to metabolic diseases.
p21 activated kinase 4 (PAK4) project
PAK4 is a member of the PAK family of serine/threonine kinases, playing roles in cytoskeleton remodeling, phenotypic signaling, and gene expression. It regulates processes such as directional motility, invasion, metastasis, and growth. To better comprehend how PAK4 signaling influences glucose and fat metabolism, as well as susceptibility to metabolic diseases, we have developed various tissue-specific Pak4 knockout mouse models.
Fundings
• Basic Science Research Program (awarded to BHP) by the Nation Research Foundation
• Technology Innovation Program (awarded to EJB) by the Ministry of Trade, Industry & Energy
• Bio & Medical Technology Development Program (awarded to EJB) by the National Research Foundation