1. Mi-Young Song, Yong Geun Jeon, Jae Do Yang, Jae Bum Kim, Eun Ju Bae*, and Byung-Hyun Park* Sirt6 deficiency in mast cells promotes adipose fibroinflammation in obesity in humans and mice through galectin-3 signaling. Nat. Commun. 17: 57 (2026)
2. In Hyuk Bang, Byung-Hyun Park*, and Eun Ju Bae* PAK4 in metabolic diseases: Regulation by nutrient signals and therapeutic implications. Exp. Mol. Med. In press.
1. Jiacheng Du, Hwang Chan Yu, Young Jae Moon, Sun-Jung Yoon, Seung-Yong Seo, Byung-Hyun Park*, and Eun Ju Bae* Negative impact of p21-activated kinase 4‒mediated AMP-activated protein kinase inhibition on sarcopenia in mice and humans. MedComm 6(12):e70508 (2025).
2. Hwang Chan Yu, Su Hyeon Park, Hye-Jin Jo, Hyunchae Sim, Mi Rin Lee, Gahee Kim, So-Young Park, Yoonji Lee*, Eun Ju Bae*, and Byung-Hyun Park* PAK4 phosphorylates cyclin dependent kinase 2 to promote the G1/S transition during adipogenesis. Exp. Mol. Med. 57(9):2121-2132 (2025).
3. Si Chen, Yu-Bin Lee, Mi-Young Song, Changjin Lim, Hwangeui Cho, Hyun Joo Shim, Jong-Suk Kim, Byung-Hyun Park, Jeon-Kyung Kim*, and Eun Ju Bae* Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice. Exp. Mol. Med. 57(2):489-500 (2025).
1. Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim*, and Eun Ju Bae* Cannabidiol inhibits IgE-
mediated mast cell degranulation and anaphylaxis in mice. Mol. Nutr. Food Res. 68:2300136 (2024).
2. Hwang Chan Yu, Yong Geun Jeon, Ann Yae Na, Chang Yeob Han, Mi Rin Lee, Jae Do Yang, Hee Chul Yu, Jung Beom Son, Nam Doo Kim, Jae Bum Kim, Sangkyu Lee*, Eun Ju Bae*, and Byung-Hyun Park* PAK4 counteracts PKA dependent lipolysis by phosphorylating FABP4 and HSL. Nat. Metab. 6(1): 94-112 (2024).
3. Dandan Wu, Hwang Chan Yu, Hye-Na Cha, Soyoung Park, Yoonji Lee, Sun-Jung Yoon, So-Young Park*, Byung-Hyun Park*, and Eun Ju Bae* PAK4 phosphorylates and inhibits AMPKα to control glucose uptake. Nat. Commun. 15: 6858 (2024).
1. Min Yan Shi, Hwang Chan Yu, Chang Yeob Han, In Hyuk Bang, Ho Sung Park, Kyu Yun Jang, Jeong Bum Son, Nam Doo Kim, Byung-Hyun Park*, and Eun Ju Bae* p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1. Nat. Commun. 14: 4987 (2023).
2. Eun Ju Bae* and Byung-Hyun Park* Multiple roles of sirtuin 6 in adipose tissue inflammation. Diabetes Metab. J. 47(2):164-172 (2023).
3. Oh Kwang Kwon, In Hyuk Bang, So Young Choi, Ju Mi Jeon, Ann Yae Na, Gao Yan, Sam Seok Cho, Sung Hwan Ki, Youngshik Choe, Jun Nyung Lee, Yun-Sok Ha, Eun Ju Bae, Tae Gyun Kwon*, Byung-Hyun Park*, and Sangkyu Lee* SIRT5 is the desuccinylase of LDHA as a novel cancer metastatic stimulator in aggressive prostate cancer. Genom. Proteom. Bioinf. 21(1):177-189 (2023).
1. Yuancheng Mao, Eun Lee, Xiaohui Yang, Eun Ju Bae*, Raok Jeon*, and Byung-Hyun Park* Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischemia-reperfusion injury in mice. J. Enzym. Inhib. Med. Chem. 37(1):2133-2146 (2022).
2. Yong Gyun Lee, Hayoung Woo, Chul Choi, Ga-Hee Ryoo, Yun-Jo Chung, Ju-Hyung Lee, Su-Jin Jung, Soo-Wan Chae, Eun Ju Bae* and Byung-Hyun Park* Supplementation with Vitis vinifera Jingzaojing leaf and shoot extract improves exercise endurance in mice. Nutrients 14:4033 (2022).
3. Yuancheng Mao, Chang Yeob Han, Lihua Hao, Younho Lee, Jung Beom Son, Hwangeun Choi, Mi Rin Lee, Jae Do Yang, Suk Kyun Hong, Kyung-Suk Suh, Hee Chul Yu, Nam Doo Kim*, Eun Ju Bae*, and Byung-Hyun Park* PAK4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation. Hepatology 76(2):345-356 (2022).
4. Hyun-Woo Kim, Ga-Hee Ryoo, Hyun-Young Jang, So-Young Rah, Dong Hyun Lee, Do-Kyun Kim, Eun Ju Bae*, and Byung-Hyun Park* NAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice. Theranostics 12(7):3316-3328 (2022).
5. Mi-Young Song, Chang Yeob Han, Young Jae Moon, Ju-Hyung Lee, Eun Ju Bae*, and Byung-Hyun Park* Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression. Nat. Commun. 13:1808 (2022).
6. Hyun-Young Jang, Do Hyun Ha, So Young Rah, Dong Hyun Lee, Sang-Myeong Lee*, and Byung-Hyun Park* Sirtuin 6 is a negative regulator of FcεRI signaling and anaphylactic responses. J. Allergy Clin. Immunol. 149(1):156-167 (2022).
1. Yuancheng Mao, Chang Yeob Han, Lihua Hao, In Hyuk Bang, Eun Ju Bae*, and Byung-Hyun Park* p21-activated kinase 4 phosphorylates peroxisome proliferator-activated receptor γ and suppresses skeletal muscle regeneration. J. Cachexia Sarcopenia Muscle 12(6):1776-1788 (2021).
2. Lihua Hao, Yuancheng Mao, Jin Park, Eun Ju Bae*, and Byung-Hyun Park* Repurposing anthelmintic praziquantel to treat psoriasis. Br. J. Pharmacol. 178(23):4726-4740 (2021).
3. Dandan Wu, In Hyuk Bang, Byung-Hyun Park*, and Eun Ju Bae* Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting. Exp. Mol. Med. 53:1298-1306 (2021).
4. In Hyuk Bang, Dami Park, Youngyi Lee, Hwangeui Cho, Byung-Hyun Park*, and Eun Ju Bae* Sirtuin 6 promotes eosinophil differentiation by activating GATA-1 transcription factor. Aging Cell 20:e13418 (2021).
5. Lihua Hao, Yuancheng Mao, Jin Park, Byoung-Mog Kwon, Eun Ju Bae*, and Byung-Hyun Park* 2′-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp. Mol. Med. 53(5):875-884 (2021).
6. Lihua Hao, Jin Park, Hyun-Young Jang, Eun Ju Bae, and Byung-Hyun Park Inhibiting protein kinase activity of pyruvate kinase M2 by SIRT2 deacetylase attenuates psoriasis. J. Invest. Dermatol. 141(2):355-363 (2021).
7. Chang Hun Lee, Yunjung Choi, Hyewon Cho, In Hyuk Bang, Lihua Hao, Seung-Ok Lee, Raok Jeon*, Eun Ju Bae*, and Byung-Hyun Park* Histone deacetylase 8 inhibition alleviates cholestatic liver injury and fibrosis. Biochem. Pharmacol. 183:114312 (2021).
1. Ga-Hee Ryoo, Young Jae Moon, Sunghee Choi, Eun Ju Bae, Jae-Ha Ryu*, and Byung-Hyun Park* Tussilagone promotes osteoclast apoptosis and prevents estrogen deficiency-induced osteoporosis in mice. Biochem. Biophys. Res. Commun. 531: 508-514 (2020).
2. Min Yan Shi, In Hyuk Bang, Chang Yeob Han, Dae Ho Lee, Byung-Hyun Park*, and Eun Ju Bae* Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis. Theranostics 10(25): 11416-11427 (2020).
3. Lihua Hao, In Hyuk Bang, Jie Wang, Yuancheng Mao, Soon-Young Na, Jae Do Yang, Jeong Kon Seo, Hueng-Sik Choi, Eun Ju Bae*, and Byung-Hyun Park* ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis. JCI Insight. 5(17):137566 (2020).
4. Eun-Soo Jung, Eun-Kyung Choi, Byung-Hyun Park*, and Soo-Wan Chae* Serum follicle-stimulating hormone levels are associated with cardiometabolic risk factors in postmenopausal Korean women. J. Clin. Med. 9:1161 (2020).
5. Eun-Ock Park, Eun-Ju Bae, Byung-Hyun Park*, and Soo-Wan Chae* The associations between liver enzymes and cardiovascular risk factors in adults with mild dyslipidemia. J. Clin. Med. 9:1147 (2020).
6. Mi-Ra Oh, Su-Jin Jung, Eun-Ju Bae, Byung-Hyun Park*, and Soo-Wan Chae* Clinical characteristics and associated risk factors of prediabetes in the southwestern region of Korea from 2010–2019. J. Clin. Med. 9:1114 (2020).
1. Young Jae Moon, Zhongkai Zhang, In Hyuk Bang, Oh Kwang Kwon, Sun-Jung Yoon, Jung Ryul Kim, Sangkyu Lee, Eun Ju Bae*, and Byung-Hyun Park* Sirtuin 6 in preosteoclasts suppresses age-and estrogen deficiency-related bone loss through estrogen receptor α stabilization. Cell Death Differ. 26(11):2358-2370 (2019).
2. In Hyuk Bang, Oh Kwang Kwon, Lihua Hao, Dami Park, Myung-Ja Chung, Byung-Chul Oh, Sangkyu Lee, Eun Ju Bae*, and Byung-Hyun Park* Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis. Exp. Mol. Med. 51(9):107 (2019).
3. Mi-Young Song, Sang Hoon Kim, Ga-Hee Ryoo, Mi-Kyung Kim, Hye-Na Cha, So-Young Park, Hong Pil Hwang, Hee Chul Yu, Eun Ju Bae*, and Byung-Hyun Park* Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans. Exp. Mol. Med. 51(5):56 (2019).
4. Jeung-Hyun Koo, Hyun-Young Jang, Youngyi Lee, Young Jae Moon, Eun Ju Bae, Seok-Kweon Yun*, and Byung-Hyun Park* Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes. Exp. Mol. Med. 51(4):48 (2019).
5. Sang Hoon Kim, Zhongkai Zhang, Young Jae Moon, Il Woon Park, Yong Gon Cho, Raok Jeon*, and Byung-Hyun Park* SPA0355 prevents ovariectomy-induced bone loss in mice. Kor. J. Physiol. Pharmacol. 23(1): 47-54 (2019).
1. Seong Ji Woo, Hae Sook Noh, Yun-Hong Cheon, Sang Mi Yi, Jin Ho Park, Eun Ju Bae, Sang-Il Lee*, and Byung-Hyun Park* Myeloid sirtuin 6 deficiency accelerates experimental and human rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium. EBioMedicine 38:228-237 (2018).
2. Ui-Jin Bae, Eun-Ock Park, John Park, Su-Jin Jung, Hyeonmi Ham, Kee-Won Yu, Young-Jun Park, Soo-Wan Chae*, and Byung-Hyun Park* Gypenoside UL4-rich Gynostemma pentaphyllum extract exerts a hepatoprotective effect on diet-induced nonalcoholic fatty liver disease. Am. J. Chinese Med. 46(6):1315-1332 (2018).
3. Hyun-Young Jang, Jeung-Hyun Koo, Sang-Myeong Lee, and Byung-Hyun Park* Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes. Exp. Mol. Med. 50:73 (2018).
4. Ui-Jin Bae, John Park, Il Woon Park, Byung Min Chae, Mi-Ra Oh, Su-Jin Jung, Geon-Seek Ryu, Soo-Wan Chae, and Byung-Hyun Park Epigallocatechin-3-gallate-rich green tea extract ameliorates fatty liver and weight gain in mice fed a high fat diet by activating the sirtuin 1 and AMP activating protein kinase pathway. Am. J. Chinese Med. 46(3):617-632 (2018).
1. Youngyi Lee, Sun-O Ka, Hye-Na Cha, Yu-Na Chae, Mi-Kyung Kim, So-Young Park, Eun Ju Bae*, and Byung-Hyun Park* Myeloid sirtuin 6 deficiency causes insulin resistance in high-fat diet-fed mice by eliciting macrophage polarization toward an M1 phenotype. Diabetes 66(10):2659-2668 (2017).
2. Sun-O Ka, In Hyuk Bang, Eun Ju Bae*, and Byung-Hyun Park* Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by upregulation of Bach1, an Nrf2 repressor. FASEB J 31(9):3999-4010 (2017)
3. Ui-Jin Bae, Mi-Ra Oh, Joon Park, Jong-Sang Park, Soo-Wan Chae, Baik Hwan Cho, and Byung-Hyun Park Supplementation with Lycium chinense fruit extract attenuates methionine choline deficient diet-induced steatohepatitis in mice. J. Funct. Foods 31:1-8 (2017).
4. Zheng Wang, Sun-O Ka, Youngyi Lee, Byung-Hyun Park, and Eun Ju Bae Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice. Eur. J. Pharmacol. 799:201-210 (2017).
5. Jie Wang, Hyung-Won Koh, Lu Zhou, Ui-Jin Bae, Hwa-Suk Lee, In Hyuk Bang, Sun-O Ka, Seon-Hee Oh, Eun Ju Bae, and Byung-Hyun Park Sirtuin 2 aggravates post-ischemic liver injury by deacetylating mitogen activated protein kinase phosphatase-1. Hepatology 65(1):225-236 (2017).