Metabolic Reprogramming Laboratory @ KAIST GSMSE

Welcome to Metabolic Reprogramming Laboratory!

Lab Introduction

Metabolic reprogramming refers to the ability of the cells to alter their energy metabolism in order to support the increased energy request due to continuous growth and metabolic stress. Such metabolic shifts are characteristic of cancer and immune cells. The intricately coordinated interplay between immune and metabolic responses is evolutionarily preserved and essential for tissue and organismal health. Disruption of these interactions contributes to the development of metabolic disorders such as obesity, diabetes, and fatty liver disease.

The laboratory, co-supervised by Professor Park at KAIST and Professor Bae at Jeonbuk National University, focuses on unraveling the role of metabolic reprogramming in the progression of metabolic diseases. Simultaneously, we actively pursue the development of small molecules or protein degraders designed to target specific metabolic reprogramming enzymes, aiming to introduce innovative therapeutic approaches for metabolic diseases.