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What is structural biology?
What is structural biology?
All cells contain macromolecules that are made of small units of molecules and they all perform very specific functions. We call these macromolecules proteins, DNA, and RNA and they all take on very specific shapes. Structural biology is the study of their shapes; how they fold into them and how they change. We now have a good understanding that the shapes of these molecules are critical to how they do their jobs. Because of their small size, scientists have invented sophisticated tools to get images of proteins, DNA, and RNA and study their motion. Computation structural biology is the use of computational tools and theory to predict their structure and behavior in time.
All cells contain macromolecules that are made of small units of molecules and they all perform very specific functions. We call these macromolecules proteins, DNA, and RNA and they all take on very specific shapes. Structural biology is the study of their shapes; how they fold into them and how they change. We now have a good understanding that the shapes of these molecules are critical to how they do their jobs. Because of their small size, scientists have invented sophisticated tools to get images of proteins, DNA, and RNA and study their motion. Computation structural biology is the use of computational tools and theory to predict their structure and behavior in time.
amino acids
amino acids
guide to the 20 amino acids (article and graphic)
polar vs non-polar (video)
the hydrophobic effect (video)
the hydrophobic effect (article)
essential vs non-essential amino acids (MedLibreTexts)
peptide bonds (KhanAcademy video)
protein structure
protein structure
levels of protein structure (Khan Academy article)
protein folding (iBiology video)
how chaperones help fold proteins (Nature article)
states of hemoglobin (video)
membrane vs soluble proteins
membrane vs soluble proteins
what are membrane proteins? (ChemLibreTexts article+videos)
types of membrane proteins (KhanAcademy video)
what are soluble proteins (lecture)
structural proteins
structural proteins
the cytoskeleton overview (BioLibreTexts)
what are microtubules? (video)
kinesin 'walking' on a microtubule (video)
motor proteins (iBiology video)
Cryo-EM and X-Ray crystallography
Cryo-EM and X-Ray crystallography
the history of x-ray crystallography (lecture)
x-ray crystallography pt1 (getting crystals) and pt2 (diffraction collection)
Cryo-electron microscopy history and explanation (video)
Cryo-EM equipment and overview (UCSF video)
Mass Spectrometry
Mass Spectrometry
isotopes and mass spectrometry? (Khan Academy video)
proteomics and mass spectroscopy (lecture)
native mass spectrometry (article)
Protein design
Protein design
protein design with Rosetta (iBiology video series)
de novo protein design (review article)
Structure Predictions
Structure Predictions
homology modeling (review article)
the protein folding problem (TEDx Talk by Ken Dill)
Machine Learning and Structure Prediction
Machine Learning and Structure Prediction
Scientist have had some recent breakthrough is using machine learning, an algorithm that learns how to predict or compute stuff by studying existing data, to predict protein structure.
AlphaFold is at the forefront of this technology
protein folding competitions and AlphaFold (video)
The same company also made a algorithm to beat the world's Go champion, check out this free documentary!
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