Transfusion
TRANSFUSUIN MODULE TRAINING
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TRANSFUSUIN MODULE TRAINING
Overall Training Goal: To ensure all personnel involved in the transfusion process understand and can correctly perform their roles, from ordering blood components to monitoring the patient, to guarantee patient safety and compliance with hospital policy and national standards.
Target Audience
This training is mandatory for all clinical staff involved in any part of the blood transfusion process. This includes, but is not limited to:
Medical Staff: Junior Doctors (Interns, Residents), Registrars, Consultants and Faculty.
Nursing Staff: Registered Nurses, Senior Nurses, and Clinical Nurse Specialists.
Students: Medical and Nursing students on clinical placement.
Phlebotomists and Healthcare Assistants: Staff involved in blood sample collection or transportation of blood components.
Training Scope
This program covers the complete clinical "vein-to-vein" transfusion chain. The scope begins with the clinical decision to transfuse and extends through ordering, sample collection, component retrieval, bedside checks, administration, patient monitoring, and the management of adverse reactions.
This program focuses on the clinical procedures and the critical interface between the wards/clinical areas and the Blood Center laboratory. It does not cover detailed internal laboratory testing procedures.
Overall Training Objectives
Upon completion of this training, participants will be able to:
Correctly order blood components using the official request form with all required information.
Safely perform the non-negotiable bedside procedure for patient identification, sample collection, and labelling to prevent errors.
Identify the main types of blood components, their clinical indications, and storage requirements.
Properly retrieve and transport blood components from the Blood Center, ensuring the cold chain is maintained.
Perform the critical three-way bedside identity check prior to initiating any transfusion.
Safely administer blood components using the correct equipment and technique.
Diligently monitor a patient for signs and symptoms of a transfusion reaction.
Recognize and initiate the immediate correct response to a suspected transfusion reaction.
Objective: To ensure all requests for blood and components are complete, accurate, and legible to prevent delays and errors.
The Importance of the Request Form
Why it Matters: The request form is the primary legal and medical document initiating the transfusion process. Incomplete or incorrect forms are a major source of error and will lead to rejection of the request.
Reference: BCMCH, PRE TRANSFUSION WORKUP; Letterkenny, LABORATORY REQUEST FORMS/ SPECIMEN CONTAINERS
Essential Information for the Request Form (MF-0230)
Patient Identifiers (MUST BE 100% ACCURATE): Full Name, Hospital Number, DOB, Gender.
Clinical Information (Crucial for Safe Component Selection): Diagnosis, reason for transfusion, lab values, transfusion/pregnancy history, patient location.
Request Details: Component, number of units, date/time needed, urgency.
Requester Information: Clinician's name, requester's signature and contact number.
Reference: BCMCH, PRE TRANSFUSION WORKUP; Letterkenny, LABORATORY REQUEST FORMS/ SPECIMEN CONTAINERS
Requesting Special Components
Clearly indicate on the request form if specific components are needed (e.g., Irradiated, CMV Negative).
Reference: BCMCH, PREPARATION OF COMPONENTS; Letterkenny, LABORATORY REQUEST FORMS/ SPECIMEN CONTAINERS
Handling Emergency Requests
For life-threatening situations, a signed written request is mandatory, stating the clinical urgency and acknowledging the risks of uncrossmatched blood.
Reference: BCMCH, CROSSMATCHING IN EMERGENCIES; Letterkenny, EMERGENCY ISSUE OF BLOOD
Objective: To master the critical, non-negotiable procedure for patient identification and sample labelling to prevent "Wrong Blood in Tube" (WBIT) errors.
The Golden Rule: The Bedside Procedure
CRITICAL POINT: Patient identification, blood draw, and sample labelling must be one continuous, uninterrupted event at the patient's bedside. Never pre-label tubes.
Reference: Letterkenny, IDENTIFYING THE PATIENT & LABELLING THE SAMPLE
Step-by-Step Sample Collection Procedure
Step 1: Prepare: Gather request form, correct sample tubes (6ml Pink Top EDTA), and venipuncture equipment.
Step 2: Identify the Patient (PPID):
Conscious Patient: Ask patient to state full name and DOB. Match this against the ID wristband and the request form.
Unconscious/Confused Patient: Match ID wristband against medical notes and request form. Verify with a second staff member.
Step 3: Perform Venipuncture.
Step 4: Label the Sample (IMMEDIATELY at the bedside):
Handwrite legibly: Full Name, DOB, Hospital Number, Date/Time, and your signature. Addressograph labels are forbidden on the sample.
Reference: BCMCH, PRE TRANSFUSION WORKUP; Letterkenny, IDENTIFYING THE PATIENT & LABELLING THE SAMPLE
Sample Quality and Rejection Criteria
The lab will reject samples that are incorrectly labelled, hemolyzed, clotted, or have a mismatched request form. A rejected sample requires a complete redraw.
Reference: BCMCH, PRE TRANSFUSION WORKUP; Letterkenny, QUALITY OF BLOOD SPECIMENS
Objective: To understand the different blood components available, their purpose, storage requirements, and shelf life.
Packed Red Blood Cells (PRBC)
Purpose: Increase oxygen-carrying capacity.
Storage: 2°C to 6°C.
Fresh Frozen Plasma (FFP)
Purpose: Correct coagulation factor deficiencies.
Storage: -30°C or colder.
Platelet Concentrate (PC)
Purpose: Prevent or treat bleeding due to low platelet counts.
Storage: 20°C to 24°C with continuous agitation. NEVER REFRIGERATE.
Cryoprecipitate
Purpose: Primarily for fibrinogen replacement.
Storage: -30°C or colder.
Reference for all above: BCMCH, PREPARATION OF COMPONENTS & QUARANTINE, STORAGE...
Apheresis Components
Single-donor components providing a full therapeutic dose.
Reference: BCMCH, SOP FOR APHERESIS
Objective: To ensure the correct component is collected for the correct patient and the cold chain is maintained during transport.
The Issue Process at the Blood Center
A dual sign-off is required where both Blood Center staff and collecting staff verify all patient and unit details before the component is released.
Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS
Time Limits and Returns
CRITICAL: Transfusion must start within 30 minutes of issue.
If delayed, the unit must be returned immediately within that 30-minute window.
Thawed products and issued platelets are never taken back.
Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS & RETURN AND RE-ISSUE OF BLOOD
Transportation
Components must be transported in validated containers to maintain required temperatures (cold for RBCs, room temp for platelets, frozen for FFP/Cryo).
Reference: BCMCH, IDENTIFICATION AND TRACEABILITY & QUARANTINE, STORAGE...
Objective: To understand the requirement and components of obtaining informed consent for transfusion.
Key Elements of Informed Consent
It is a documented conversation about the benefits, risks, and alternatives to transfusion.
The physician is responsible, and the process must be documented before the transfusion begins.
Reference: BCMCH, POLICY AND PROCEDURES
Objective: To perform the final, critical bedside identity check to ensure the right blood is given to the right patient.
The Final Safety Net
This check must be performed at the patient's bedside by two qualified personnel.
The Three-Way Match
Verify information on the Patient's ID Wristband, the Blood Component Compatibility Tag, and the Medical Order.
Check: Patient Name, Hospital Number, Blood Groups (patient and unit), Unit Number, Component Type, and Expiry Date.
CRITICAL: If any discrepancy exists, DO NOT TRANSFUSE. Contact the Blood Center.
Objective: To correctly and safely administer blood components using the proper equipment and technique.
Equipment and Setup
Use a dedicated IV line with a standard blood filter.
Prime with 0.9% Normal Saline ONLY.
NO MEDICATIONS are to be added to the blood or the line.
Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS
Infusion Rates and Times
First 15 Minutes: Start slow (~2 mL/min). The nurse must remain with the patient.
Maximum Infusion Time: Must be completed within 4 hours of removal from the blood center.
Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS
Objective: To diligently monitor the patient for signs of an adverse reaction throughout the transfusion.
Vital Signs Monitoring
Take a full set of vital signs:
Baseline (before starting)
At 15 minutes
Periodically during transfusion (e.g., hourly)
At completion
Patient Observation
Continuously observe for any signs of a reaction (fever, chills, rash, shortness of breath, pain, etc.).
Objective: To respond immediately and correctly to a suspected transfusion reaction.
IMMEDIATE ACTIONS at the Bedside
Step 1: STOP THE TRANSFUSION.
Step 2: MAINTAIN IV ACCESS with 0.9% Normal Saline (new line and tubing).
Step 3: NOTIFY the physician and the Blood Center.
Laboratory Investigation
Send the following to the Blood Center: the blood bag and tubing, a post-transfusion blood sample, a post-transfusion urine sample, and the completed Transfusion Reaction Form.
Reference: BCMCH, TRANSFUSION REACTION AND EVALUATION; Letterkenny, BLOOD TRANSFUSION TESTS
Documentation and Reporting
Document all events and actions in the medical record.
The Blood Center will report findings to the Hospital Transfusion Committee and participate in Hemovigilance programs.
Reference: BCMCH, TRANSFUSION REACTION AND EVALUATION & QUALITY ASSESSMENT AND UTILIZATION REVIEW
Objective: To master the correct procedure for completing a blood transfusion request form, ensuring all information is accurate, legible, and complete to prevent delays and critical errors in the transfusion process.
1.1 The Importance of the Request Form
Objective: To understand that the request form is the foundational medical and legal document of the transfusion episode and the first critical control point for patient safety.
Key Talking Points:
The transfusion request form is not just an order slip; it is a medical prescription for a biological product. It is the single most important piece of communication between the clinical team and the Blood Center.
It serves as the starting point for the patient's transfusion record. All information on this form becomes part of their permanent medical file and is crucial for traceability in the event of an adverse reaction or look-back investigation.
The Blood Center laboratory has no other information about the patient's immediate clinical situation besides what is written on this form. Its accuracy and completeness directly impact the safety and efficiency of the service they can provide.
Rationale / Why This Matters:
To Prevent Delays: An incomplete or illegible form forces the laboratory staff to stop their work. They must then contact the ward or the requesting doctor to clarify information. This wastes valuable time, delaying the provision of blood to a patient who may need it urgently.
To Prevent Errors: Ambiguous requests can lead to the wrong component being prepared or issued. For example, a request for "plasma" could be interpreted as FFP or another plasma product, which have different clinical uses.
To Ensure Safety: Missing clinical history, especially a history of previous transfusions or pregnancies, is a significant safety risk. The lab uses this information to decide the extent of antibody screening required. Without it, a clinically significant antibody could be missed, potentially leading to a severe or fatal transfusion reaction.
Practical Application / Scenario:
A request form arrives at the lab for "2 units" for a patient in the surgical ward. The form does not specify the component (PRBC? Platelets?). The clinical details are blank. The lab cannot proceed. The technician must call the ward, identify the nurse caring for the patient, who then has to find the doctor who wrote the request. This 20-minute delay could have been avoided if the form had been completed correctly.
Critical Warning: An incomplete form is an unsafe form. The Blood Center is professionally and ethically obligated to reject any request that does not meet the minimum information requirements. This is a safety measure, not an inconvenience
Reference: BCMCH, PRE TRANSFUSION WORKUP;
1.2 Essential Information for the Request Form
Objective: To identify and correctly document all mandatory fields on the request form, understanding the specific purpose of each piece of information.
A. Patient Identifiers (The "Big Four" - Must Be 100% Accurate)
Key Talking Points:
Patient’s Full Name (Surname, Forename): Must be spelled correctly and completely.
Patient’s Hospital Number (PCN / UHID): This unique number is the most reliable identifier.
Patient’s Date of Birth (DOB): A critical secondary identifier.
Patient’s Gender: Important for clinical context and component selection.
Rationale / Why This Matters:
This information is the cornerstone of patient identification. Any error here creates a risk of a "Wrong Blood in Tube" (WBIT) incident, where a sample is taken from the wrong patient but labelled with the details from the incorrect form.
The lab uses these identifiers to cross-check against their historical database for the patient. A match confirms the patient's blood group history and any previously identified antibodies. A mismatch (e.g., a different DOB for the same PCN) brings the entire process to a halt until the patient's identity is unequivocally confirmed.
B. Clinical Information (Tells the Lab Why You Need Blood)
Key Talking Points:
Diagnosis and Reason for Transfusion: Be specific (e.g., "Upper GI bleed," "Symptomatic anemia post-chemo," "Pre-op for hip replacement").
Relevant Lab Values: Hemoglobin (for PRBC) or Platelet count (for platelets). This provides clinical justification.
Transfusion and Pregnancy History: This is a CRITICAL SAFETY FIELD. You must indicate if the patient has ever had a blood transfusion or, for female patients, has ever been pregnant.
Rationale / Why This Matters:
Clinical Justification: This allows the Blood Center's medical staff to ensure the transfusion is appropriate and adheres to rational use guidelines. A request for PRBC for a stable patient with a Hb of 10 g/dL will be queried.
Antibody Risk: Pregnancy and transfusion are the primary events that can cause a person to develop red cell antibodies. If the lab knows about this history, they can perform more extensive testing to detect these antibodies, which can cause life-threatening reactions. Omitting this information can lead the lab to perform a standard, less sensitive test, potentially missing a dangerous antibody.
C. Request and Requester Details
Key Talking Points:
Specific Component and Number of Units: (e.g., "2 units PRBC," "1 unit Apheresis Platelets").
Date and Time Required & Urgency: (Routine / Urgent / Emergency). This dictates the lab's workflow and priority.
Requester’s Name, Signature, and Contact Number (Bleep/Ext): The form is invalid without a signature. The contact number is essential for the lab to communicate any problems or critical results.
Rationale / Why This Matters:
A clear request prevents ambiguity. An urgent request will be prioritized over routine work. Without a contact number, the lab cannot reach you if they find an antibody and are struggling to find compatible blood, or if the sample is rejected.
Critical Warning: The transfusion and pregnancy history directly impacts the safety tests performed by the lab. Omitting this information is a direct risk to the patient.
Reference: BCMCH, PRE TRANSFUSION WORKUP;
1.3 Requesting Special Components
Objective: To understand when and how to request specially processed blood components to meet specific patient needs.
Key Talking Points:
Standard blood components are not suitable for all patients. Certain conditions require specially processed products. This requirement must be clearly written on the request form. The lab cannot guess.
Common Special Components:
Irradiated Components: The blood is exposed to gamma radiation to inactivate donor T-lymphocytes.
Purpose: To prevent fatal Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD).
Indicated for: Severely immunocompromised patients (e.g., bone marrow transplant recipients, patients on certain chemotherapy drugs), donations from relatives, and intrauterine transfusions.
CMV Negative Components: The blood is from a donor who has tested negative for Cytomegalovirus.
Purpose: To prevent CMV transmission.
Indicated for: CMV-negative at-risk patients, such as pregnant women, neonates, and transplant recipients.
Washed Red Cells: The red cells are washed with saline to remove almost all of the plasma.
Purpose: To prevent severe allergic reactions in patients with a history of anaphylaxis to blood components or those with IgA deficiency.
Practical Application / Scenario:
A patient with a history of severe allergic reactions (anaphylaxis) to blood transfusions needs a PRBC unit. The doctor forgets to write "Washed Red Cells" on the form. The lab issues a standard PRBC unit. When the transfusion is started, the patient develops another severe anaphylactic reaction. This was an avoidable adverse event.
Critical Warning: Special requirements are not optional extras; they are critical safety modifications for specific patients. Failure to request them can lead to severe or fatal complications. Always specify them on the form.
Reference: BCMCH, PREPARATION OF COMPONENTS;
1.4 Handling Emergency Requests
Objective: To understand the formal process and responsibilities when requesting blood in a life-or-death emergency where a delay is unacceptable.
Key Talking Points:
This procedure is reserved for true clinical emergencies, such as massive hemorrhage or life-threatening anemia with hemodynamic instability. It bypasses some routine safety checks, so the risk is higher.
The Emergency Release Protocol:
Verbal Request: The clinician should first call the Blood Center directly to alert them of the emergency.
Written Request: A formal, signed written request must be sent to the lab. This is a non-negotiable legal and procedural step.
Wording on the Form: The request must explicitly state the nature of the emergency and that blood is required before compatibility testing can be completed. Example: "Patient with massive postpartum hemorrhage, requires 2 units PRBC emergently. I accept the responsibility for transfusing uncrossmatched blood."
What the Lab Will Do:
If the patient’s blood group is unknown, the lab will issue Group O, RhD Negative Packed Red Cells. This is the universal donor for red cells and carries the lowest risk of an immediate severe reaction in an unknown recipient.
As soon as a sample arrives, the lab will determine the patient's group and switch to group-specific blood as quickly as possible.
Rationale / Why This Matters:
The signed emergency request form is a formal record of the clinical decision to proceed with a higher-risk transfusion because the risk of not transfusing (death from exsanguination) is greater than the risk of the transfusion itself. It provides a clear audit trail and confirms that the clinician has taken responsibility for this critical decision.
Critical Warning: The emergency release protocol is an exception for life-threatening situations only. The signed request form acknowledging the urgency and accepting the risk is a mandatory part of this protocol.
Reference: BCMCH, CROSSMATCHING IN EMERGENCIES
Objective: To master the critical, non-negotiable procedure for positive patient identification and sample labelling to prevent "Wrong Blood in Tube" (WBIT) errors, which are considered the most dangerous errors in transfusion medicine.
2.1 The Golden Rule: The Bedside Procedure
Objective: To ingrain the understanding that patient identification and sample labelling is a single, uninterruptible, high-stakes procedure that must only be performed at the patient’s side.
Key Talking Points:
This is the most critical safety step you will perform in the transfusion process. There are no shortcuts and no exceptions. An error here can directly lead to a patient’s death.
The "One Patient, One Phlebotomist, One Time" Principle:
Focus on only one patient at a time. Do not carry request forms or sample tubes for multiple patients simultaneously. This is a common source of mix-ups.
The person who performs the venipuncture is the only person who can label the sample. You cannot delegate this task.
The entire process—from identifying the patient to labelling the tube—must be completed in one continuous event at the bedside without interruption or distraction.
Rationale / Why This Matters:
Preventing WBIT: The term "Wrong Blood in Tube" describes a scenario where a blood sample is taken from Patient A, but the tube is labelled with the details of Patient B. If this sample reaches the lab, the lab will crossmatch blood for Patient B using Patient A's blood. This can lead to a perfectly crossmatched unit of blood being issued for the wrong patient, resulting in a potentially fatal ABO-incompatible transfusion.
The Chain of Error: A WBIT error is almost impossible for the laboratory to detect. The sample and the form will match perfectly, and the lab will correctly perform all its tests. The error can only be caught at the final bedside check before administration, if at all. The best way to manage this risk is to prevent the error at the source: during sample collection.
No Second Chances: Once an unlabelled or incorrectly labelled sample leaves the bedside, its integrity is lost forever. It cannot be "fixed" later by trying to remember which sample belonged to which patient. It must be discarded.
Practical Application / Scenario:
A busy nurse has two transfusion requests. She prepares two sets of tubes and labels them both at the nursing station to save time. She goes to the first patient's room and draws the blood. She then goes to the second patient's room and does the same. At some point, she may have inadvertently swapped the pre-labelled tubes. This is a classic WBIT error waiting to happen. The correct procedure is to take only one form and one set of tubes to the first patient, complete the entire process, and only then move on to the second patient.
Critical Warning: Pre-labelling tubes is strictly forbidden. It is the most common cause of WBIT errors. The tube must be unlabelled when you approach the patient and must be fully labelled before you walk away from them.
Reference: IDENTIFYING THE PATIENT & LABELLING THE SAMPLE
2.2 Step-by-Step Sample Collection Procedure (The "Zero-Tolerance" Protocol)
Objective: To execute the precise, sequential steps for sample collection and labelling with 100% accuracy every time.
Step 1: Prepare (Away from the Bedside)
Key Talking Points:
Gather all necessary equipment:
The correct, fully completed request form (MF-0230).
The correct, unlabelled sample tube (6ml Pink Top EDTA for adults).
Venipuncture supplies (tourniquet, alcohol wipe, needle, etc.).
A pen for labelling.
Wash your hands and put on gloves.
Step 2: Identify the Patient (Positive Patient Identification - PPID) (At the Bedside)
Key Talking Points: This is a three-point check. All three sources must match exactly.
Ask the Patient: If the patient is conscious and able, ask them to actively state their full name and date of birth. Do not ask leading questions like, "Are you John Smith?". Ask open-ended questions: "Can you please tell me your full name?" and "Can you please tell me your date of birth?".
Check the Wristband: Compare the patient's verbal response to the information printed on their hospital ID wristband.
Check the Request Form: Compare the information on the wristband to the information on the request form.
What if the Patient is Unconscious or Confused?
You cannot ask them to identify themselves, so this part of the check is omitted.
You must then perform a two-point check: compare the patient’s ID wristband against the medical notes and the request form.
Crucially, this identification must be verified with a second qualified staff member at the bedside. Both of you must agree on the patient's identity.
What if the Patient has No ID Wristband?
DO NOT PROCEED. A wristband must be created and attached to the patient before a sample for transfusion can be taken.
Step 3: Perform Venipuncture (At the Bedside)
Key Talking Points:
Perform the blood draw using standard aseptic technique.
Collect the sample into the correct 6ml Pink Top EDTA tube.
Ensure the tube is filled sufficiently.
Step 4: Label the Sample (IMMEDIATELY at the Bedside)
Key Talking Points: This is the most critical final action.
While still at the patient's bedside, take your pen and handwrite the following details directly onto the tube label.
Mandatory Information on the Tube:
Patient’s Full Name
Date of Birth (DOB)
Patient’s Hospital Number (PCN / UHID)
Date and Time of Sample Collection
Your Signature (as the person who collected and labelled the sample).
CRITICAL POINT: Addressograph labels (stickers) are strictly forbidden on the sample bottle. The adhesive can fail in the laboratory's refrigerated storage, and labels can be applied to the wrong tube. Handwriting is a deliberate, conscious action that forces you to confirm the details as you write them.
After labelling, do a final mental check: "Does the information I just wrote on this tube match the patient's wristband in front of me?"
Step 5: Finalize (At the Bedside)
Key Talking Points:
Place the now fully labelled sample tube and the corresponding request form together in the biohazard bag.
Only now is it safe to leave the patient's bedside.
Critical Warning: Your signature on the tube is a professional declaration. It means: "I personally identified this patient, I personally drew this blood, and I personally labelled this tube at the bedside."
Reference: BCMCH, PRE TRANSFUSION WORKUP
2.3 Sample Quality and Rejection Criteria
Objective: To recognize the types of sample collection errors that will lead to an automatic rejection by the laboratory, requiring a repeat blood draw.
Key Talking Points:
The laboratory acts as a final safety checkpoint. They will critically examine every sample and form that arrives. If there is any doubt about the sample's integrity or the patient's identity, they will reject it.
Common Reasons for Rejection:
Labelling Errors (Most Common):
Missing information on the tube or form (e.g., no signature, no DOB).
Mismatched information between the tube and the form.
Use of an addressograph label on the sample tube.
Illegible handwriting.
Specimen Quality Issues:
Hemolysis: The breakdown of red cells, which releases hemoglobin into the plasma/serum, turning it pink or red. This can interfere with many of the lab's tests, especially crossmatching, and can mask a true reaction. Hemolysis is often caused by a difficult blood draw, using too small a needle, or shaking the tube too vigorously.
Clotted Sample: An EDTA tube that was not mixed properly after collection may contain clots, which makes the sample unusable.
Inadequate Sample: Insufficient blood volume in the tube for the required tests.
Wrong Tube Type: Samples for transfusion testing must be in a Pink Top EDTA tube.
What Happens When a Sample is Rejected?
The lab will immediately contact the ward or the requesting doctor to inform them of the rejection and the reason.
The patient must have a complete new blood sample drawn. The original, rejected sample cannot be "fixed" or re-labelled.
This inevitably causes a delay in providing blood for the patient.
Critical Warning: A rejected sample is not a critique of your work; it is a critical safety intervention. The lab is protecting the patient from a potential error you may have inadvertently made. The only remedy is a fresh, correctly collected, and correctly labelled sample
Reference: BCMCH, PRE TRANSFUSION WORKUP;
Objective: To gain a comprehensive understanding of the different blood components available, their specific clinical purposes, critical storage requirements, and administration considerations, in order to select and use them rationally and safely.
3.1 The Principle of Component Therapy
Objective: To understand why modern transfusion medicine focuses on using specific components rather than whole blood.
Key Talking Points:
What is Component Therapy? It is the practice of separating a single unit of donated whole blood into its constituent parts (components). This allows a single donation to treat multiple patients with different needs.
The Rationale - "Give Only What is Needed":
Targeted Treatment: Patients rarely need all the elements of whole blood. A patient with anemia needs oxygen-carrying capacity (red cells), not extra plasma volume or clotting factors. A patient with a clotting disorder needs plasma, not red cells. Component therapy allows for precise, targeted treatment of the patient's specific deficit.
Maximizing a Scarce Resource: One blood donation can be separated into Packed Red Cells, Platelets, and Fresh Frozen Plasma (or Cryoprecipitate), potentially helping three or more patients. This is the cornerstone of efficient blood resource management.
Enhanced Safety: By not giving patients components they don't need, we reduce the risk of complications. For example, giving whole blood to a patient who only needs red cells unnecessarily increases their circulatory volume, which can lead to Transfusion-Associated Circulatory Overload (TACO), especially in elderly patients or those with cardiac impairment.
Practical Application / Scenario:
A stable, non-bleeding patient with chronic renal failure has a hemoglobin of 6.5 g/dL. They are anemic but have a normal plasma volume and platelet count.
Wrong Treatment: Giving them a unit of Whole Blood would provide the needed red cells but would also give them ~200 mL of unnecessary plasma, increasing their risk of fluid overload.
Correct Treatment: Giving them a unit of Packed Red Blood Cells (PRBC) provides the same oxygen-carrying capacity in a much smaller volume (~280-350 mL total), directly addressing their deficit with minimal risk.
Key Principle: The default practice is to transfuse components, not whole blood. Whole blood is reserved for very specific, rare situations like massive, rapid hemorrhage where both volume and oxygen-carrying capacity are needed simultaneously and components are not immediately available.
Reference: BCMCH, POLICY AND PROCEDURES & PREPARATION OF COMPONENTS
3.2 Packed Red Blood Cells (PRBC)
Objective: To understand the characteristics, purpose, and critical handling requirements of Packed Red Blood Cells.
What it is: A unit of whole blood with approximately 80% of the plasma removed by centrifugation, leaving a concentrated suspension of red blood cells. The final hematocrit is typically high (55-70%).
Primary Purpose: To increase the oxygen-carrying capacity of the blood in patients with symptomatic anemia or significant blood loss. The decision to transfuse should be based on the patient's symptoms and clinical context, not just a hemoglobin number.
Key Characteristics:
Volume: Approximately 280-350 mL.
Expected Outcome: One unit of PRBC should raise the hemoglobin level by approximately 1 g/dL (or the hematocrit by ~3%) in a typical, non-bleeding adult.
Critical Storage Requirement: Must be stored in a validated blood bank refrigerator at 2°C to 6°C. Temperature deviations can lead to bacterial growth (if too warm) or hemolysis (if frozen).
Shelf Life / Expiry: 35 days (in CPDA-1 anticoagulant) or 42 days (if an additive solution like SAGM is present). The expiry date is clearly marked on the bag.
Special Variations:
Leukocyte-Depleted: Most PRBCs are now filtered to remove white blood cells, which reduces the risk of febrile reactions, CMV transmission, and alloimmunization.
Washed: As discussed in Module 1, for patients with severe allergic reactions.
Irradiated: For immunocompromised patients to prevent TA-GVHD.
Critical Handling Point: Once a unit of PRBC is removed from the Blood Center's controlled refrigerator, the "4-hour rule" begins. The transfusion must be completed within 4 hours to minimize the risk of bacterial contamination at room temperature.
Reference: BCMCH, PREPARATION OF COMPONENTS & QUARANTINE, STORAGE...
3.3 Platelet Concentrate (PC)
Objective: To understand the unique properties and extremely sensitive handling requirements of platelets.
What it is: A concentration of platelets suspended in a small volume of plasma. Can be prepared from a single whole blood donation ("random donor platelet") or collected from a single donor via an apheresis machine ("apheresis" or "single donor platelet"). An apheresis unit contains the equivalent of 4-6 random donor units.
Primary Purpose: To prevent or control bleeding in patients with thrombocytopenia (low platelet count) or platelet dysfunction.
Key Characteristics:
Volume: ~50-70 mL for a random unit; ~200-300 mL for an apheresis unit.
Appearance & Quality Check: Healthy platelets have a characteristic "swirling" appearance (like a kaleidoscope) when gently agitated. Absence of swirling indicates poor platelet quality and the unit should not be used.
Critical Storage Requirement: Must be stored at 20°C to 24°C (room temperature) with continuous, gentle agitation. This prevents the platelets from clumping together and maintains their viability.
Shelf Life / Expiry: A very short 5 days from the date of collection. This is due to the high risk of bacterial growth in a component stored at room temperature.
Critical Handling Point: NEVER refrigerate platelets. Cold temperatures cause irreversible activation and damage, rendering them useless for transfusion. They are issued from the Blood Center "ready to use" and should be transfused immediately. They cannot be returned.
Reference: BCMCH, PREPARATION OF COMPONENTS & QUARANTINE, STORAGE...; SOP FOR APHERESIS
3.4 Fresh Frozen Plasma (FFP)
Objective: To understand the purpose and correct handling of FFP, particularly the thawing process.
What it is: The plasma portion separated from a unit of whole blood and frozen solid within hours of collection to preserve all coagulation factors.
Primary Purpose: To treat bleeding due to multiple coagulation factor deficiencies. It is not to be used as a simple volume expander.
Common Indications:
Reversal of warfarin effect when prothrombin complex concentrate (PCC) is unavailable.
Treatment of bleeding in patients with severe liver disease.
Disseminated Intravascular Coagulation (DIC).
Plasma exchange procedures (e.g., for TTP).
Key Characteristics:
Volume: Approximately 200-250 mL.
Critical Storage Requirement: Stored frozen at -30°C or colder.
Shelf Life / Expiry: 1 year from the date of collection.
Thawing Process: FFP must be thawed in the Blood Center in a controlled 37°C water bath or plasma defroster. This takes approximately 20-30 minutes. Never thaw FFP in a microwave or hot water on the ward. This will denature the proteins.
Critical Handling Point: Once thawed, FFP must be used promptly. Its labile clotting factors (Factor V and VIII) degrade quickly at room temperature. It should be transfused as soon as possible, and in any event, within 12-24 hours if stored at 2-6°C. Thawed FFP cannot be refrozen or returned to the blood bank.
Reference: BCMCH, PREPARATION OF COMPONENTS & QUARANTINE, STORAGE...
3.5 Cryoprecipitate
Objective: To understand the specific, concentrated purpose of cryoprecipitate.
What it is: The cold-insoluble precipitate that is collected after FFP is thawed slowly in a refrigerator. It is a very small-volume, highly concentrated source of specific clotting factors.
Primary Purpose: Fibrinogen replacement. It is the component of choice for treating bleeding in patients with significant hypofibrinogenemia (e.g., in DIC or massive hemorrhage).
Key Contents: Rich in Fibrinogen, Factor VIII, von Willebrand Factor, and Factor XIII.
Key Characteristics:
Volume: A very small volume, typically 10-20 mL per unit. Multiple units (usually 5-10) are often pooled together to create a therapeutic dose for an adult.
Critical Storage Requirement: Stored frozen at -30°C or colder.
Shelf Life / Expiry: 1 year from the date of collection.
Thawing and Administration: Thawed in the Blood Center like FFP. Because it is often pooled, it must be used very quickly after preparation.
Critical Handling Point: Once thawed and pooled, cryoprecipitate must be used within 4 hours. It is a very fragile product. It is prepared on-demand and must be administered immediately upon arrival on the ward.
Reference: BCMCH, PREPARATION OF COMPONENTS & QUARANTINE, STORAGE...
Objective: To master the procedures for correctly collecting the right component for the right patient from the Blood Center and ensuring its integrity and safety are maintained during transport to the bedside.
4.1 The Issue Process at the Blood Center: A Formal Handover
Objective: To understand that collecting a blood component is a formal, documented handover of a prescribed therapeutic product, requiring a final verification by both Blood Center and clinical staff.
Key Talking Points:
This is the final checkpoint within the laboratory environment before the component is released to the clinical area. It is a critical control point designed to catch any potential errors before they leave the lab.
Only trained and authorized personnel (e.g., staff nurses, doctors, designated porters in some protocols) are permitted to collect blood components.
The "Challenge and Response" Protocol at the Issue Hatch:
The Challenge (What you must provide): When you arrive at the Blood Center, you must be prepared to provide at least two unique patient identifiers. This is not a casual request. You must state:
The patient’s full name.
The patient’s hospital number (PCN / UHID).
The patient’s date of birth.
The Response (What the Blood Center staff will do): The Blood Center technician will take the information you provided and use it to locate the specific, crossmatched unit(s) for that patient. They will bring the component and the accompanying paperwork to the issue hatch.
The Dual Sign-Off: A Shared Responsibility
Key Talking Points: This is the most crucial part of the handover. It is a dual, independent check performed by two people: the Blood Center staff member and the person collecting the component. Both are equally responsible for ensuring its accuracy.
The Blood Center staff will hold up the blood bag and the attached compatibility tag.
Together, you will verbally confirm, point-by-point, the following details:
Patient's Full Name: Match the name on the compatibility tag to the patient details you provided.
Patient's Hospital Number: Match the PCN/UHID on the tag to the one you provided.
Patient's Blood Group (ABO/Rh): Confirm it is correct.
Blood Unit Number: Read the unique donation number on the blood bag and ensure it matches the number on the compatibility tag.
Component Type: Confirm it is the correct component (e.g., "Packed Red Cells," "Platelets").
Blood Group of the Component: Confirm it is compatible with the patient's group.
Expiry Date and Time: Check that the unit has not expired.
Final Actions:
Visual Inspection: The Blood Center staff will perform a final visual inspection of the unit in front of you, checking for any leaks, discoloration, clots, or signs of hemolysis.
Signing the Register: Once both parties are satisfied that all details are correct, the person collecting the blood must sign the Blood Center's issue register. This is a legal record of the handover. You will enter your name, the patient's details, the unit number, and the date and time of collection. The Blood Center staff member will also sign.
Rationale / Why This Matters:
This formal, two-person check is designed to catch "wrong-unit" errors, where the correct unit for Patient A is mistakenly handed out for Patient B. It ensures that the right unit, which has been carefully tested and crossmatched, is leaving the lab for the intended recipient. Your signature in the register confirms you have participated in this check and accepted responsibility for the component.
Critical Warning: Do not be a passive observer during this check. You are an active participant in a critical safety procedure. If you are distracted or rushed and fail to spot an error, you share in the responsibility for any adverse outcome. If you have any doubt, however small, do not sign and do not take the bag. Ask the Blood Center staff to re-verify
Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS
4.2 Time Limits and Returns: Protecting the Product's Viability
Objective: To understand and strictly adhere to the critical time and temperature limits for blood components once they leave the controlled environment of the Blood Center.
The 30-Minute Rule for Red Cells and Thawed Products
Key Talking Points:
Once a unit of Packed Red Cells (or a thawed product like FFP/Cryo) is issued, a clock starts. The transfusion must be initiated at the bedside within 30 minutes.
This is not an arbitrary number. It is the maximum time a refrigerated component can be exposed to room temperature before the risk of clinically significant bacterial growth begins to increase.
The cold temperature (2-6°C) slows down the growth of any potential bacteria that may have entered the bag during donation. At room temperature, these bacteria can multiply rapidly.
What if there is a delay? (e.g., the patient's IV access fails, the patient refuses, the doctor cancels the order).
You have a 30-minute window to return the unit to the Blood Center.
If the unit is returned immediately and within this 30-minute window, the Blood Center can place it back into the validated refrigerator, and it can be re-issued later.
If the unit has been out of the refrigerator for more than 30 minutes, it cannot be returned to stock. It is considered potentially contaminated and unsafe for any other patient. It will be taken back by the lab for disposal only.
Non-Returnable Products: Platelets and Thawed Components
Key Talking Points:
Platelets: Because they are stored at room temperature and have a very short shelf life, they are highly susceptible to bacterial growth. Once issued, they are considered committed to that patient and cannot be returned. They must be transfused immediately.
Thawed FFP and Cryoprecipitate: The thawing process is irreversible. Once thawed, the labile clotting factors begin to degrade. They cannot be refrozen. Therefore, thawed products cannot be returned.
Rationale / Why This Matters:
These rules are entirely about patient safety. A unit of red cells left on a counter for an hour and then transfused could contain a lethal dose of bacteria. A unit of platelets returned and re-issued to another patient the next day could be a bag of bacteria. Adhering to these time limits is a non-negotiable part of preventing septic transfusion reactions.
Critical Handling Point: Plan ahead. Before you go to collect a blood component, ensure the patient is ready, their consent is documented, and their IV access is patent and working. Do not collect the blood and then try to get everything else ready
Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS & RETURN AND RE-ISSUE OF BLOOD
4.3 Transportation: Maintaining the Cold Chain
Objective: To use the correct equipment and methods to transport blood components, ensuring their temperature remains within the safe, required range from the lab to the ward.
The "Cold Chain" Concept for Refrigerated and Frozen Products
Key Talking Points:
The "cold chain" is an unbroken chain of refrigerated or frozen storage and transport. Maintaining this chain is essential for the safety and efficacy of red cells and frozen components.
Simply carrying a unit of blood in your hand or pocket from the lab to a ward on a different floor is unacceptable. The unit will warm up too quickly.
Correct Transportation Methods:
Validated Transport Containers: The hospital provides specially designed, insulated containers (coolers or transport boxes) for moving blood components. These are validated to maintain the required temperature for a specific period.
Red Cells (PRBC): Must be transported in a container that maintains a temperature between 2°C and 10°C.
Frozen Components (FFP, Cryoprecipitate): Must be transported in a manner that keeps them frozen solid (e.g., in a special container, sometimes with dry ice for longer distances). Thawed products should be transported quickly to be used immediately.
Transporting Platelets
Key Talking Points:
Platelets are the exception. They must be kept at room temperature (20°C to 24°C).
They should be transported carefully and promptly, without exposure to extreme heat or cold. Do not place them next to a radiator or on a cold windowsill.
Rationale / Why This Matters:
A break in the cold chain for red cells can lead to two major problems:
Bacterial Growth: As seen with the 30-minute rule, warmth encourages bacteria.
Hemolysis: If a bag is accidentally exposed to freezing temperatures (e.g., placed directly on a freezer block), the red cells can freeze, rupture (hemolyze), and release free hemoglobin, which is toxic and can cause kidney failure if transfused.
Correct transport ensures the product that arrives at the bedside is the same quality as the product that left the lab.
Critical Warning: Always use the designated, validated transport containers for moving blood components around the hospital. Do not improvise. The integrity of the product you are about to transfuse depends on it.
Reference: BCMCH, IDENTIFICATION AND TRACEABILITY & QUARANTINE, STORAGE...
Objective: To understand and correctly facilitate the process of obtaining informed consent for blood transfusion, recognizing it as a critical patient-centered dialogue that respects patient autonomy and fulfills legal and ethical obligations.
5.1 What is Informed Consent? More Than a Signature
Objective: To shift the perspective of consent from a bureaucratic task to a meaningful clinical conversation.
Key Talking Points:
The Foundational Principle: Informed consent is rooted in the ethical principle of patient autonomy. Every competent adult has the right to make decisions about their own body and medical treatment. They have the right to accept or refuse any medical intervention, including a blood transfusion.
A Process, Not a Piece of Paper: While a signed form is the final documentation, it is merely the evidence that a process has taken place. The core of informed consent is the dialogue between the healthcare provider and the patient. It is an exchange of information that empowers the patient to make a voluntary and informed choice.
The Goal of the Conversation: The aim is to ensure the patient has a clear, practical understanding of their situation so they can weigh the potential benefits against the potential risks and decide on a course of action that aligns with their own values and wishes.
Rationale / Why This Matters:
Ethical Obligation: Respecting a patient's autonomy is a cornerstone of modern medical ethics. Proceeding with a transfusion without consent (except in very specific emergency situations) can be considered battery.
Legal Requirement: In most jurisdictions, informed consent is a legal prerequisite for medical treatment. Failure to obtain it can have significant legal consequences for the clinician and the hospital.
Shared Decision-Making: The process fosters a partnership between the patient and the clinical team. When patients feel they are part of the decision, they are more likely to trust the team and adhere to the treatment plan. It moves away from a paternalistic "doctor knows best" model to a collaborative one.
Managing Expectations: A good consent discussion helps manage patient expectations. If they are aware of common, minor side effects (like a mild fever), they are less likely to be anxious if one occurs.
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Key Principle: The signed consent form is the end product of the consent process. The process itself is the conversation. If the conversation never happened or was inadequate, the signature is meaningless.
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Reference: BCMCH, POLICY AND PROCEDURES (specifically Sec 7.1.12)
5.2 Key Elements of the Consent Discussion
Objective: To learn and be able to articulate the essential components of information that must be conveyed to the patient.
The "BRAN" Mnemonic (Benefits, Risks, Alternatives, No/Nothing):
1. B - Benefits (Why are we recommending this?)
Key Talking Points: Explain in simple, clear language why the transfusion is necessary. Avoid medical jargon.
Instead of: "We need to transfuse you to correct your hypoxemic state secondary to your low hemoglobin."
Say: "Your blood count is low, which means your body isn't getting enough oxygen. This is why you're feeling so tired and short of breath. This bag of red blood cells will help raise your blood count and carry more oxygen, which should help you feel stronger and breathe more easily."
For Platelets: "Your platelet count is very low, and platelets are the cells that help your blood to clot. We need to give you a platelet transfusion to reduce your risk of serious bleeding."
2. R - Risks (What are the potential downsides?)
Key Talking Points: You must provide a balanced overview of the potential risks. It's important to be honest without causing unnecessary alarm. Group risks into common/minor and rare/serious categories.
Common, Minor Risks: "Some people can have a mild reaction. You might feel a bit feverish or get an itchy rash. These are usually not serious and we can treat them easily with medication."
Less Common, More Serious Risks: "Less often, a patient might have a more serious allergic reaction or difficulty breathing from the extra fluid. We will be monitoring you very closely to watch for any of these signs."
Rare, Serious Risks: "The risk of getting a serious infection from a blood transfusion in our country is now extremely rare, because every donation is very carefully tested. The risk is much, much lower than the risk of many other medical procedures." (You can often quantify this as less than 1 in a million for HIV/Hepatitis).
TAILOR THE RISKS: For a young, Rh-negative woman, the risk of alloimmunization (developing antibodies that could affect a future pregnancy) is a relevant risk to mention.
3. A - Alternatives (Are there other options?)
Key Talking Points: Discuss any viable alternatives to transfusion for this specific patient.
Example for chronic anemia: "For now, a transfusion is the quickest way to help you feel better. For the long term, we can also give you iron tablets (or an iron infusion) to help your body build its own red blood cells, but that will take several weeks to work."
Example for surgical bleeding: "During your surgery, the surgeon can use techniques to minimize blood loss, and we can also use a machine to collect and give you back your own blood."
In many acute situations, you may need to explain, "Unfortunately, in your current situation with this amount of bleeding, there are no safe and effective alternatives to a blood transfusion."
4. N - No/Nothing (The Right to Refuse)
Key Talking Points: The patient must explicitly be told that they have the right to say no.
Say: "After hearing all of this, it is your decision. You have the right to refuse the transfusion. If you choose to do that, it's important you understand the consequences. In your case, not having the transfusion could mean..." (explain the likely outcome, e.g., continued severe symptoms, risk of heart strain, etc.).
5. Opportunity for Questions
Key Talking Points: Always end the discussion by asking, "Do you have any questions for me?" and "Do you understand what we've discussed?". Give the patient time to think and respond.
5.3 Responsibility and Documentation
Objective: To understand who is responsible for the consent process and how it must be documented correctly.
Responsibility:
Ultimate Responsibility: The prescribing physician (the doctor ordering the transfusion) holds the ultimate responsibility for ensuring that informed consent has been obtained.
Delegation: The physician may delegate the task of conducting the consent conversation and obtaining the signature to another competent healthcare professional, such as a trained staff nurse or a junior doctor. However, the responsibility remains with the prescriber.
Competence: The person conducting the discussion must be knowledgeable enough to answer the patient's questions accurately. If they cannot, they must seek assistance from a senior clinician.
Documentation:
When to Document: Consent must be obtained and documented before the transfusion is started (and ideally, before the request is even sent to the Blood Center).
Where to Document:
Consent Form: The patient (or their legal representative) should sign and date the hospital's official consent form for blood transfusion. The healthcare professional who conducted the discussion must also sign and date the form as a witness to the process.
Patient’s Medical Record: A note should be made in the patient's progress notes summarizing the consent discussion. This note should confirm that the benefits, risks, and alternatives were discussed, that the patient was given the opportunity to ask questions, and that they agreed to proceed.
Example Note: "Discussed need for PRBC transfusion with patient for symptomatic anemia (Hb 6.8). Benefits (improved oxygenation, relief of symptoms), risks (febrile/allergic reaction, fluid overload, rare risk of infection), and alternatives (iron therapy, slower acting) explained. Patient verbalized understanding and agreed to proceed. Consent form signed and placed in chart."
Special Circumstances:
Incompetent Patient: If an adult patient lacks the capacity to make a decision (e.g., due to dementia, delirium, or being unconscious), consent must be sought from their legally authorized representative or next-of-kin, following hospital policy and local laws on advance directives and healthcare proxies.
Emergency Situation: In a true life-threatening emergency where the patient is unable to consent and no representative is available, treatment can be given without consent under the doctrine of necessity, on the grounds that it is in the patient's best interests. This must be clearly documented in the patient's record by at least two physicians if possible, explaining why it was not possible to obtain consent.
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Critical Documentation Point: If it isn't documented, it didn't happen. A signature on a form with no corresponding note in the medical record is weak evidence of a proper consent process. Robust documentation protects the patient, the clinician, and the hospital.
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Reference: BCMCH, POLICY AND PROCEDURES (specifically Sec 7.1.12)
Objective: To master the final, critical, multi-step identity verification process performed at the patient’s bedside to ensure the correct blood component is administered to the correct patient, thereby preventing a potentially fatal transfusion error.
6.1 The Final Safety Net: The Last Chance to Prevent Catastrophe
Objective: To understand the profound importance of the bedside check as the final barrier against a catastrophic mis-transfusion.
Key Talking Points:
The Most Dangerous Error: The single most common cause of death from blood transfusion is an ABO-incompatible transfusion—giving the wrong blood group to a patient (e.g., Group A blood to a Group O patient). This is almost always the result of a human error in patient or component identification.
The "Swiss Cheese" Model of Safety: Think of transfusion safety as a series of barriers (slices of Swiss cheese). An error can only reach the patient if all the holes in the cheese line up.
Slice 1: Correctly ordering the blood.
Slice 2: Correctly collecting and labelling the sample (WBIT prevention).
Slice 3: Correct laboratory testing.
Slice 4: Correctly issuing the unit from the Blood Center.
The Final, Solid Barrier: The bedside check is the last, and arguably most important, barrier. It is a solid slice of cheese with no holes. Even if errors have occurred in the preceding steps (e.g., a WBIT error that the lab couldn't detect), this final, diligent check is designed to catch it before the blood enters the patient's vein.
A "Forcing Function": This procedure is a "forcing function" – a step that is intentionally designed to be deliberate and slightly cumbersome to force you to slow down, focus, and prevent you from proceeding on autopilot.
Rationale / Why This Matters:
The consequences of getting this step wrong are severe and immediate. An ABO-incompatible transfusion can trigger a massive, acute intravascular hemolytic reaction. The recipient’s antibodies attack and rapidly destroy the transfused red cells, leading to shock, kidney failure, Disseminated Intravascular Coagulation (DIC), and often, death. Almost every one of these events is preventable by the correct execution of this bedside check.
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Critical Principle: This is not a routine task. It is a high-stakes, zero-tolerance safety procedure. It demands your full, undivided attention. Do not perform this check if you are rushed, distracted, or in a poorly lit environment. Stop, take a breath, and focus.
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6.2 The Core Procedure: The Three-Way Match
Objective: To learn and demonstrate the physical process of comparing three separate sources of information at the patient’s bedside.
The Two-Person Rule:
Key Talking Points: This check must be performed by two qualified and competent staff members. This typically means two Registered Nurses or a doctor and a Registered Nurse.
One person (the "reader") should read the information aloud from the blood component tag and bag.
The second person (the "checker") should simultaneously and independently check that information against the patient's wristband and the medical prescription/chart.
This dual, independent check significantly reduces the risk of "confirmation bias," where a single person might see what they expect to see.
The Three Sources of Truth:
The Patient: The patient is identified via their ID Wristband. This is the primary source of truth for the patient's identity.
The Product: The blood component is identified via the Compatibility Tag attached to the blood bag by the Blood Center.
The Prescription: The order is identified via the medical order/prescription chart.
The Step-by-Step Verification Process:
Step 1: Assemble at the Bedside: Both staff members and all three sources of information (the patient with their wristband, the blood component with its tag, and the patient's chart with the prescription) must be present at the bedside.
Step 2: Check the Prescription: First, confirm there is a valid, signed medical order for the transfusion in the patient's chart.
Step 3: Begin the Three-Way Match (Reader and Checker): The reader will state each item from the compatibility tag aloud, and the checker will verify it against the other two sources.
"Patient's Full Name"
Reader: Reads the name from the compatibility tag (e.g., "Smith, John").
Checker: Looks at the patient's wristband and the prescription chart and confirms, "Matches wristband, matches chart."
"Patient's Hospital Number"
Reader: Reads the PCN/UHID from the tag (e.g., "One-Two-Three-Four-Five-Six").
Checker: Looks at the wristband and chart and confirms, "Matches wristband, matches chart."
"Patient's Blood Group"
Reader: Reads the patient's blood group from the tag (e.g., "O Positive").
Checker: Confirms this matches the group written on the prescription chart.
"Donation Unit Number"
Reader: Reads the unique donation number from the tag (e.g., "W-One-Two-Three...").
Checker: Compares this to the number on the blood bag itself. They must match exactly. The checker also confirms this number matches the unit number written on the prescription.
"Blood Group of the Component"
Reader: Reads the blood group printed on the blood bag label (e.g., "O Positive").
Checker: Confirms this is compatible with the patient's blood group.
"Component Type"
Reader: Reads the component type from the tag/bag (e.g., "Packed Red Cells").
Checker: Confirms this matches the component ordered in the prescription.
"Expiry Date and Time"
Reader: Reads the expiry date and time from the bag.
Checker: Confirms the unit has not expired.
Step 4: Final Visual Inspection: Both staff members should jointly inspect the unit one last time for any signs of damage or deterioration:
Discoloration: Is the plasma in the bag an unusual color (e.g., dark purple, black)? This can indicate bacterial contamination.
Hemolysis: Is the plasma visibly pink or red? This indicates red cells have been damaged.
Clots: Are there any visible clots in the bag?
Leaks: Is the bag intact with no signs of leakage?
Step 5: Documentation: Once the check is complete and everything matches, both staff members must sign the transfusion record/compatibility form, documenting that the check was performed, by whom, and at what time. This creates a permanent record of this safety step.
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Critical Warning: If there is ANY discrepancy, no matter how minor, STOP. DO NOT TRANSFUSE. A small spelling difference, a single digit off in the hospital number—any mismatch must be resolved before proceeding. Contact the Blood Center immediately for guidance. Do not try to "fix" the problem yourself.
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6.3 Handling Special Situations
Objective: To understand how to adapt the bedside check for patients who cannot be identified in the standard way.
The Unconscious or Confused Patient:
The Challenge: The patient cannot participate in their own identification.
The Process: The core three-way match remains the same, but the "Ask the Patient" step is omitted. The check relies entirely on the Patient's ID Wristband, the Compatibility Tag, and the Prescription Chart. The need for two staff members to perform this check is even more critical in this scenario.
The Unidentified "Trauma" Patient:
The Challenge: The patient has no name or known identity.
The Process: These patients are assigned a unique identification number (e.g., a "Trauma Number" or "L Number") and gender. This unique number becomes their primary identifier.
The wristband will be labelled with this unique number and gender (e.g., "Trauma 1234, Male").
The request form will use this number.
The blood component compatibility tag will use this number.
The bedside check then becomes a match of this unique number and gender across all three sources (wristband, tag, and chart).
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Critical Documentation Point: Every detail of the bedside check, including the names and signatures of the two people who performed it, must be recorded. This documentation is the legal and professional proof that this vital safety step was completed correctly.
Objective: To master the correct, safe, and aseptic techniques for the physical administration of blood components, including the proper use of equipment, adherence to infusion rates, and awareness of critical safety protocols.
7.1 Equipment and Setup: Preparing for a Safe Infusion
Objective: To correctly select, prepare, and set up the intravenous equipment required for a blood transfusion, preventing component damage and contamination.
1. Intravenous (IV) Access
Key Talking Points:
A patent and well-functioning IV cannula is essential. Before proceeding, assess the patient's IV site for any signs of phlebitis, infiltration, or blockage.
Cannula Size: A larger gauge cannula (e.g., 20G or 18G) is preferred for routine red cell transfusions to allow for an adequate flow rate without damaging the cells. Smaller gauges (e.g., 22G) can be used but may require slower infusion rates. For rapid, emergency transfusions, the largest possible access is required.
Dedicated Line: Whenever possible, blood components should be transfused through a dedicated IV line. This means no other infusions, especially medications, should be running through the same cannula simultaneously. This prevents drug-blood interactions within the line.
2. The Blood Administration Set
Key Talking Points:
You must use a specific blood administration set, not a standard IV infusion set.
The Integral Filter: The key feature of this set is the in-line filter, which is designed to trap small clots and aggregates of cells and platelets that can form during storage. The standard filter size is 170-260 microns.
Single Use: A blood administration set is typically used for a limited number of units or a limited time, as per hospital policy (e.g., good for 2-4 units or for a maximum of 12 hours). The filter can become clogged over time, and the risk of bacterial growth increases. A new set must be used for each transfusion episode.
3. Priming the Line: The "Saline Only" Rule
Key Talking Points: This is a critical, non-negotiable rule of transfusion practice.
The blood administration set must only be primed with 0.9% Sodium Chloride (Normal Saline).
Why Only Saline?
Dextrose Solutions (e.g., 5% Dextrose - D5W): Dextrose is hypotonic. If it comes into contact with red blood cells, it will cause them to swell and burst (hemolysis) right in the tubing. This is extremely dangerous.
Ringer's Lactate / Hartmann's Solution: These solutions contain calcium. The citrate anticoagulant in the blood bag works by binding calcium. If a calcium-containing solution is mixed with the blood, it can overwhelm the citrate and cause the blood to clot in the bag and tubing.
Medications: Many medications are incompatible with blood and can cause hemolysis or clotting.
The Priming Procedure:
Spike the bag of 0.9% Normal Saline.
Fill the drip chamber of the administration set about halfway.
Slowly open the roller clamp to allow the saline to run through the entire length of the tubing, ensuring all air is expelled.
Close the roller clamp. The line is now primed and ready.
4. The "No Additives" Rule
Key Talking Points:
ABSOLUTELY NO MEDICATIONS or other IV solutions are to be added directly to the bag of blood.
The blood bag is a closed, sterile system. Puncturing the bag to add a drug compromises its sterility and introduces the risk of bacterial contamination.
The chemical compatibility of most drugs with stored blood is unknown and unpredictable. Adding a drug could cause hemolysis, clotting, or inactivate the drug itself.
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Critical Warning: Using any solution other than 0.9% Normal Saline to prime the line or to run with the blood is a serious medication error that can cause direct harm to the patient. If the patient needs medication during the transfusion, it must be given through a separate, second IV line at a different site.
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Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS (specifically Sec 31.5.5, 31.5.6)
7.2 Initiating and Managing the Infusion
Objective: To safely initiate the transfusion, manage the infusion rate, and adhere to the maximum time limits for administration.
1. Connecting the Component
Key Talking Points:
After the bedside check is complete, you are ready to connect the blood.
Gently invert the blood bag several times to ensure the cells are evenly mixed. Do not shake vigorously.
Using an aseptic technique, close the roller clamp on the saline, remove the cap from the blood bag port, and insert the second spike of the Y-type administration set into the blood bag.
Hang the blood bag and open the roller clamp leading from it, while keeping the clamp to the saline bag closed.
2. The First 15 Minutes: The Critical Observation Period
Key Talking Points:
The most severe, life-threatening transfusion reactions (like an acute hemolytic reaction) usually occur within the first few minutes of the transfusion, after only a small volume of blood has been infused.
For this reason, the first 15 minutes are a period of heightened observation.
Start the transfusion SLOWLY. A typical rate is 2 mL/minute (which is 120 mL/hour on an infusion pump).
The responsible nurse must remain with the patient during this entire 15-minute period. You cannot start the transfusion and then leave the room.
During this time, you are actively monitoring the patient for any early signs of a reaction: changes in vital signs, anxiety, back pain, difficulty breathing, chills, etc.
3. Adjusting the Infusion Rate
Key Talking Points:
After the first 15 minutes, if the patient is stable and showing no signs of a reaction, take a full set of vital signs.
If all is well, the infusion rate can now be increased to the prescribed rate.
The rate will depend on the patient's clinical condition:
Routine Transfusion: A unit of red cells is typically infused over 2 to 3 hours.
Risk of Fluid Overload: In elderly patients or those with heart or kidney failure, the transfusion may need to be given much more slowly, up to the maximum of 4 hours, sometimes with a diuretic given between units.
Emergency/Trauma: In a patient who is actively bleeding, blood may be infused as fast as the IV line will allow, often under pressure.
4. The 4-Hour Rule: The Maximum Infusion Time
Key Talking Apoints:
A unit of red cells (or any component removed from controlled storage) must be fully infused within 4 hours of the time it was removed from the Blood Center refrigerator (or from the time the seal on a room-temperature component like platelets is spiked).
This is a strict microbiological safety limit. After 4 hours at room temperature, the risk of bacterial proliferation within the bag becomes clinically significant, potentially leading to septic shock.
If the transfusion is not completed within 4 hours, the remaining portion in the bag must be discarded. The transfusion cannot be continued.
5. Special Components: Platelets and FFP
Platelets: Are typically infused rapidly, usually over 15-30 minutes. A slow infusion is not necessary or beneficial.
Fresh Frozen Plasma (FFP): Also typically infused rapidly over 15-30 minutes to ensure the patient receives the clotting factors while they are still active.
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Critical Warning: The 4-hour rule is an absolute maximum. It starts from the moment the unit is issued from the Blood Center, not from the moment you spike the bag. Always check the issue time on the compatibility tag to manage your time effectively.
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Reference: BCMCH, ISSUE OF BLOOD AND ITS COMPONENTS (specifically Sec 31.17, 31.18, 31.19)
7.3 Completion and Documentation
Objective: To correctly complete the transfusion process and ensure all actions are accurately documented in the patient's record.
Key Talking Points:
Once the component has fully infused, close the roller clamp to the blood bag and open the clamp to the saline bag. Flush the line with a small amount of 0.9% Normal Saline to ensure the patient receives all the blood in the tubing.
Take a final set of post-transfusion vital signs.
Documentation: Record the following in the patient’s medical record/transfusion form:
The start and end time of the transfusion.
The total volume infused.
The pre- and post-transfusion vital signs.
A note on how the patient tolerated the procedure (e.g., "Tolerated well, no adverse reaction noted.").
Disposal: Dispose of the empty blood bag and administration set in the appropriate clinical biohazard waste container, according to hospital policy.
Traceability: Many hospitals require a peel-off sticker from the blood bag, containing the unique unit number, to be placed in the patient's chart. This is a crucial part of the "vein-to-vein" traceability audit trail.
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Critical Documentation Point: Accurate documentation is essential for patient safety and is a legal requirement. It provides a clear record of the transfusion episode and is vital for investigating any delayed reactions or for future transfusion planning.
Objective: To master the skills of diligent and systematic patient monitoring during a blood transfusion, enabling the early detection of adverse reactions and ensuring timely intervention.
8.1 The Rationale for Monitoring: Why We Watch So Closely
Objective: To understand the clinical and physiological reasons why close monitoring is a non-negotiable component of safe transfusion practice.
Key Talking Points:
A "Liquid Organ Transplant": A blood transfusion is essentially the transplant of living tissue from one person to another. The recipient's body may recognize this tissue as foreign and mount an immune response. This response is the basis for most transfusion reactions.
Early Detection is Key to Survival: The severity of many transfusion reactions, particularly acute hemolytic reactions, is directly related to the volume of incompatible blood infused. By monitoring the patient closely, especially at the start of the transfusion, we can detect a reaction after only a small amount of blood has been given, stop the transfusion, and significantly reduce the harm to the patient. A reaction that is missed for an hour can be fatal, while one caught in the first 10 minutes may be entirely manageable.
Differentiating Reactions: Monitoring allows us to distinguish between different types of reactions. For example, a fever can be a sign of a simple, benign febrile reaction, or it can be the first sign of life-threatening hemolysis or bacterial sepsis. The pattern and timing of symptoms, combined with vital sign changes, help to build a clinical picture.
Non-Immune Complications: Monitoring is not just for immune reactions. It is also crucial for detecting non-immune complications like Transfusion-Associated Circulatory Overload (TACO). A rising respiratory rate and falling oxygen saturation in an elderly patient receiving a transfusion are classic signs of TACO and require immediate intervention (slowing or stopping the transfusion and administering diuretics).
Practical Application / Scenario:
A patient begins to feel anxious and complains of a "funny feeling" 10 minutes into a transfusion. The nurse, who is diligently monitoring, immediately checks the vital signs and notes a rise in heart rate and a drop in blood pressure. She recognizes these as early signs of a serious reaction, stops the transfusion, and calls the doctor. Because the reaction was caught after only 20 mL of blood was infused, the patient's outcome is excellent. If the nurse had not been present and the full unit had infused, the patient could have progressed to irreversible shock and kidney failure.
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Key Principle: Monitoring is not passive observation. It is an active process of surveillance, combining objective measurements (vital signs) with subjective patient assessment and a high index of suspicion. You are looking for any deviation from the patient's baseline.
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8.2 The Vital Signs Monitoring Schedule: A Structured Approach
Objective: To learn and follow the standard, structured schedule for monitoring and documenting vital signs during a transfusion.
Key Talking Points:
A structured schedule ensures that checks are performed consistently and at the most critical time points. It provides a documented trend of the patient's physiological response over time.
The Standard Schedule:
Baseline Check (Within 30-60 minutes before starting):
Action: Take a full set of vital signs: Temperature, Pulse, Blood Pressure, and Respiratory Rate. Ask the patient how they are feeling at baseline.
Purpose: This establishes the patient's normal "starting point." Without a baseline, you have no way of knowing if a subsequent measurement represents a significant change. If the patient is already febrile before the transfusion starts, this is critical information to document and may require a discussion with the physician before proceeding.
The 15-Minute Check (The Most Critical Check):
Action: After the transfusion has been running slowly for 15 minutes, take another full set of vital signs.
Purpose: This is the time when the most severe acute hemolytic reactions are most likely to manifest. Any significant change from baseline at this point is a major red flag and requires an immediate response (stopping the transfusion).
Periodic Checks (During the Transfusion):
Action: Continue to monitor vital signs periodically throughout the remainder of the transfusion. Hospital policy will dictate the exact frequency, but a common standard is every hour.
Purpose: This is to detect delayed reactions or developing complications like fluid overload. A patient's blood pressure might be stable at 15 minutes but start to rise an hour later as their circulatory system struggles with the added volume.
Completion Check (Immediately after the transfusion is finished):
Action: Take a final set of vital signs.
Purpose: This provides a final data point for the transfusion episode and can help detect reactions that begin towards the end of the infusion. It also serves as a new baseline for the post-transfusion period.
What constitutes a "significant change"?
This depends on the patient's baseline, but general red flags include:
Temperature: A rise of 1°C or more from baseline.
Pulse/Heart Rate: An increase of >20 beats per minute.
Blood Pressure: A drop in systolic BP of >30 mmHg (suggests hemolysis/sepsis) or a rise in systolic BP of >30 mmHg (can be a sign of TACO or a hypertensive reaction).
Respiratory Rate: A significant increase, especially if accompanied by new-onset shortness of breath.
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Critical Documentation Point: Every set of vital signs taken must be meticulously documented on the patient's transfusion record or in the nursing notes, along with the exact time they were taken. This creates a legal and clinical record of your monitoring and allows anyone to see the trend over time.
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8.3 Patient Observation: Looking and Listening Beyond the Numbers
Objective: To develop the clinical assessment skills to recognize the subjective signs and symptoms of a transfusion reaction.
Key Talking Points:
Vital signs are crucial, but they don't tell the whole story. Some of the earliest and most important signs of a reaction come from what the patient tells you and what you observe.
Trust Your Patient: If a patient who felt fine a few minutes ago now says they "feel wrong," "feel funny," or have a "sense of impending doom," believe them. This vague but powerful symptom is a classic sign of a serious hemolytic reaction.
A Systematic Checklist of Signs and Symptoms to Look and Ask For:
General:
Fever, chills, rigors (uncontrollable shaking): The most common signs of a reaction.
Anxiety, restlessness, feeling of "impending doom."
Skin:
Itching (Pruritus).
Rash, hives (Urticaria).
Flushing (redness of the face and neck).
Swelling of the face, lips, or tongue (angioedema - a medical emergency).
Respiratory:
Shortness of breath (Dyspnea).
Wheezing or coughing.
Listen to the patient's chest: Are there new crackles (suggesting fluid overload/TACO)? Or wheezes (suggesting an allergic reaction)?
Pain:
Pain at the IV site or along the vein: Can be an early local sign.
Chest pain or tightness.
Abdominal pain or nausea.
Flank or lower back pain: This is a classic sign of an acute hemolytic reaction as red cell breakdown products affect the kidneys.
Cardiovascular:
Palpitations or a racing heart (Tachycardia).
Dizziness or light-headedness (Hypotension).
Renal:
Change in urine color: Ask the patient to report if their urine looks red, brown, or "cola-colored." This is a late but definitive sign of hemolysis.
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Key Clinical Skill: Combine objective and subjective data. A fever alone might be a simple febrile reaction. But a fever combined with back pain and a drop in blood pressure is a medical emergency that is highly suggestive of a hemolytic reaction. Your ability to connect these dots is critical. The first step in every case is to STOP THE TRANSFUSION.
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8.4 Documentation of Monitoring
Objective: To ensure all monitoring activities are accurately and contemporaneously documented.
Key Talking Points:
Use the designated Transfusion Record form provided by the hospital.
Record every set of vital signs with the corresponding time.
Document any subjective symptoms reported by the patient or objective signs you observe (e.g., "Patient c/o itching on arms at 14:30," "New onset crackles heard in lung bases at 15:00.").
If no reaction occurs, a final summary note is still required (e.g., "Unit #W123456 infused from 14:00 to 16:30. Patient tolerated well, no adverse reaction noted. Post-transfusion vitals stable.").
This complete record is essential for quality assurance, for investigating any delayed reactions, and as a legal document proving that the standard of care for monitoring was met.
Objective: To be able to recognize a potential transfusion reaction, initiate immediate and correct life-saving interventions at the bedside, and facilitate the subsequent investigation process in a systematic and timely manner.
9.1 Recognizing a Transfusion Reaction: The "High Index of Suspicion"
Objective: To understand the wide spectrum of potential adverse reactions and to maintain a high index of suspicion for any new symptom that develops during or shortly after a transfusion.
Key Talking Points:
A transfusion reaction is any unfavorable event that occurs in a patient during or after the transfusion of blood or blood components.
The Spectrum of Severity: Reactions range from mild and easily manageable (e.g., a simple itchy rash) to severe and life-threatening (e.g., anaphylactic shock or acute hemolysis).
The Rule of Thumb: Any new or unexpected sign or symptom that develops during a transfusion should be considered a transfusion reaction until proven otherwise. It is always safer to over-react by stopping the transfusion than to under-react and miss a developing catastrophe.
Timing as a Clue:
Acute Reactions: Occur within 24 hours of the transfusion. The most severe reactions (hemolytic, anaphylactic, septic) usually occur within the first 15 minutes.
Delayed Reactions: Occur more than 24 hours after the transfusion (e.g., delayed hemolytic reaction, post-transfusion purpura, graft-versus-host disease). These are often identified through follow-up lab tests or a new drop in hemoglobin days later. This module focuses on managing acute reactions.
Review of Key Signs and Symptoms (from Module 8):
Fever/Chills: The most common presentation.
Rash/Itching/Hives: Suggests an allergic reaction.
Shortness of Breath/Wheezing: Suggests allergic reaction or circulatory overload.
Back/Flank/Chest Pain: A red flag for hemolysis.
Hypotension/Shock: A red flag for hemolysis, sepsis, or anaphylaxis.
Anxiety/"Sense of Impending Doom": A classic sign of a severe reaction.
Change in Urine Color: A sign of hemolysis.
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Key Principle: Do not try to diagnose the specific type of reaction at the bedside. Your first and only priority is to recognize that something is wrong and to initiate the immediate emergency response. The specific diagnosis will come later from the investigation.
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9.2 Immediate Actions at the Bedside: The "STOP, MAINTAIN, NOTIFY" Protocol
Objective: To learn and be able to execute the three critical, life-saving steps to take the moment a transfusion reaction is suspected.
Step 1: STOP THE TRANSFUSION (The Single Most Important Action)
Action: Immediately close the roller clamp on the blood administration set.
Rationale: This is the single most effective intervention you can perform. It prevents any more of the potentially harmful blood component from entering the patient's body. The severity of many reactions is dose-dependent, so stopping the infusion limits the damage. There are no exceptions to this rule.
Step 2: MAINTAIN IV ACCESS
Action:
Do not remove the patient's IV cannula. You will need this line for emergency drugs and fluids.
Disconnect the entire blood administration set from the patient's IV hub.
Immediately connect a brand new IV infusion set primed with 0.9% Normal Saline and keep the vein open (KVO rate).
Rationale: Disconnecting the blood tubing prevents any more blood from the line from being accidentally flushed into the patient. Maintaining the IV line with saline ensures you have immediate venous access to administer emergency medications (e.g., antihistamines, steroids, adrenaline) or fluids to support blood pressure, as ordered by the physician.
Step 3: NOTIFY (Initiate the Team Response)
Action:
Notify the responsible physician immediately. Clearly and calmly state the situation: "Dr. Smith, I have stopped the blood transfusion on Mr. Jones in Bed 4. He has developed a fever of 39°C and is shaking uncontrollably. I need you to come and assess him now."
Notify the Blood Center immediately. Call the transfusion laboratory and state: "This is Nurse [Your Name] on [Your Ward]. We have a suspected transfusion reaction on patient John Smith, PCN 123456. The transfusion has been stopped."
Rationale: Notifying the physician brings immediate medical assessment and treatment to the patient. Notifying the Blood Center initiates their investigation protocol. They will quarantine any other units that may have been prepared for that patient and will prepare for the arrival of the post-transfusion samples.
Additional Bedside Actions:
Assess the Patient: While waiting for the physician, perform a rapid assessment. Check a full set of vital signs. Check the patient's airway, breathing, and circulation (ABC).
Provide Supportive Care: Reassure the patient. Position them for comfort (e.g., sit them up if they are short of breath). Administer oxygen if needed and ordered.
Perform a Clerical Check: While one nurse is attending to the patient, the second nurse should immediately re-perform the bedside check (Module 6), comparing the patient's wristband, the compatibility tag, and the blood bag to look for a clerical error. This is a crucial first step in the investigation.
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Critical Sequence: STOP. MAINTAIN. NOTIFY. These three steps must be performed rapidly and in this order. Do not delay stopping the transfusion to call the doctor first. Stop the blood, then get help.
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9.3 The Laboratory Investigation: Gathering the Evidence
Objective: To correctly collect and dispatch all the required materials to the Blood Center to facilitate a thorough and accurate investigation into the cause of the reaction.
Key Talking Points:
Once the patient is stable, your next responsibility is to gather the "evidence" for the laboratory. The lab needs specific items to perform their investigation. A delay or error in providing these materials will delay the diagnosis.
The Transfusion Reaction "Kit" to be sent to the Lab:
The Blood Bag and Administration Set:
Action: Keep the blood bag and the attached IV tubing intact. Do not discard them. Place them in a sealed biohazard bag.
Rationale: The lab will use the remaining blood in the bag for several critical tests:
To re-confirm the blood group of the unit.
To perform a Gram stain and bacterial culture if sepsis is suspected.
To visually inspect the blood for hemolysis or other abnormalities.
The Post-Transfusion Blood Sample:
Action: Draw a fresh blood sample from the patient. This must be from a different venipuncture site, preferably the opposite arm from the transfusion.
Required Tube: A Pink Top EDTA tube (the same type used for the original crossmatch sample).
Rationale: Drawing from the opposite arm prevents contamination of the sample with blood from the transfusion line. The lab will use this sample to:
Perform a Direct Antiglobulin Test (DAT) to see if the patient's red cells have been coated with antibody in vivo.
Visually inspect the patient's post-transfusion serum for hemolysis (a pink or red color).
Repeat the patient's blood group and crossmatch to check for errors.
The Post-Transfusion Urine Sample:
Action: Collect the first urine sample the patient passes after the reaction has occurred.
Rationale: The lab will test this sample for the presence of free hemoglobin (hemoglobinuria). The presence of hemoglobin in the urine is a definitive sign that a hemolytic reaction has occurred.
The Completed Transfusion Reaction Form:
Action: Fill out the hospital's official Transfusion Reaction Investigation form completely and legibly.
Rationale: This form provides the lab with all the crucial clinical information: the patient's pre- and post-reaction vital signs, a description of the signs and symptoms, the time the reaction occurred, the volume of blood infused, and any treatments given. This clinical context is essential for the lab to correctly interpret their test results.
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Critical Warning: The quality of the laboratory investigation depends entirely on the quality of the specimens you provide. A hemolyzed blood sample (from a difficult draw) is useless for checking for in-vivo hemolysis. A missing blood bag prevents a bacterial culture. Ensure all items are collected correctly and sent to the lab promptly.
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Reference: BCMCH, TRANSFUSION REACTION AND EVALUATION; Letterkenny, BLOOD TRANSFUSION TESTS
9.4 Documentation and Follow-Up
Objective: To understand the importance of comprehensive documentation and the role of the wider hospital safety systems.
Key Talking Points:
Medical Record Documentation: Meticulously document the entire event in the patient's progress notes. Include:
The time the reaction was noted.
A detailed description of the signs and symptoms.
The time the transfusion was stopped.
All vital signs.
All interventions performed (e.g., "Saline commenced, Dr. Smith notified, O2 applied").
The patient's response to the interventions.
Hospital Safety Systems:
The completed Transfusion Reaction Form will be reviewed by the Blood Center's medical staff and the hospital's Transfusion Committee.
This committee analyzes all transfusion reactions to identify trends, review the appropriateness of care, and implement system-wide improvements.
Serious reactions are reported to national bodies as part of the Hemovigilance program, which tracks transfusion safety on a national level. Your accurate reporting is a vital part of this larger patient safety network.
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Final Principle: Every transfusion reaction, no matter how mild, is a learning opportunity. A thorough investigation and report helps protect not only the current patient but also future patients within the hospital and across the country. Your role in this process is absolutely critical.
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Reference: BCMCH, TRANSFUSION REACTION AND EVALUATION & QUALITY ASSESSMENT AND UTILIZATION REVIEW