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March 2023: Margarida participated as an faculty instructor in FRET, FLIM and Metabolic Imaging workshop at Keck Center for Cellular Imaging at University of Virginia, Charlottesville, VA. Margarida gave two oral presentations on Fluorescence lifetime FRET small animal in vivo imaging: 1) Comparison of intensity versus lifetime-based approaches for quantitative FRET imaging of small animals in vivo; 2) Macroscopy fluorescence lifetime FRET monitors tumor drug-target engagement in vivo. Catherine Sherry participated as a student to learn more about the intricacies of FLIM and FRET! Go here for more information on the FRET workshop at UVA.
January 2023: Congratulations to Catherine Sherry for her best poster award at the SPIE Photonics West 2023 Multiphoton microscopy conference XIV. Also congratulations to Amit Verma for his talk at SPIE Photonics West 2023 Drug distribution conference on the role of tumor microenvironment on drug-target engagement using MFLI FRET in vivo imaging (Photos).
January 2023: Welcome Arun Asif to the Barroso lab at AMC! Arun has joined the lab as a postdoc working on the role of endosome-mitochondria interactions in 3D tumor systems and metastatic growth.
January 2023: Welcome Kavya Nair to the Barroso lab at AMC! Kavya is a first-year graduate student that works on DMT1 interacting proteins and other protein candidates involved in endosome-mitochondria interactions.
December 2022: Congratulations to Jonathan Barra for his talk on the regulation of iron metabolism via DMT1-dependent endosome-mitochondria interactions and its association with metastatic capacity of breast cancer cells at the "Mitochondrial Organization and Inter-organelle Contacts" minisymposium at Cell Bio ASCB|EMBO meeting in Washington DC (Photos).
December 2022: Margarida Barroso presented our collaborative effort with John Williams (City of Hope) to measure drug-target engagement of antibody anti-cancer drugs using in vivo macroscopy fluorescence lifetime (MFLI) Forster Resonance Energy Transfer (FRET) at NCI IMAT PI meeting at University of Kansas (Photos).
September 2022: @barrosolab was awarded a R21 entitled "Artificial intelligence enhanced cancer cell classification based organelle morphology and topology". This is a multi-PI grant with Dr. Barroso (AMC) and Dr Kruger (RPI) as PIs and Dr. Lamar (AMC) and Dr. Intes (RPI) as collaborators. This R21 is part of ITCR (https://itcr.cancer.gov/).
Spring 2022: Welcome Amit and Cassie! Amit Verma joined the @barrosolab as a postdoc in March 2022. He is working with Intes lab @RPI_BME to test the role of tumor microenvironment in drug-HER2 tumor binding using FLIM-FRET optical in vivo imaging. Cassie Roberge joined the @barrosolab as a postdoc in June 2022. She is working with Corr lab @RPI_BME to study development of tumor heterogeneity in 3D tumor systems.
07/01/2021: Congratulations to Ray Abini-Agbomson for his Master thesis defense! Ray is now a Master graduate and a 1st year medical student at AMC. Wishing Ray success for the next four years of medical school!
06/24/2021: Congratulations to Dr. Wang for her flash talk and poster in #elmi2021 European Light Microscopy Initiative Meeting on organelle topology as a novel breast cancer cell classifier.
Congratulations to Dr. Barra for his oral presentations at ASBMB Experimental Biology meeting on April 29-30, 2021.
Dr. Jonathan Barra will present his work on the "Role of iron transporter DMT1 in endosome-mitochondria interactions and mitochondrial metabolism in breast cancer cells" at the American Association of Cancer Research Meeting. On demand starting April 10, 2021.
Dr. Rudkouskaya will present her work on "Monitoring receptor heterodimerization along intracellular trafficking pathways using anti-HER2 therapeutic antibodies" at SPIE Photonics West (Paper 11624-12). On-demand starting 6 March.
Dr. Tubbesing will present her work on "Raman mapping of transferrin and ferritin distributions in breast cancer cells" at SPIE Photonics West (Paper 11655-44). On-demand starting 6 March.
01/21/2021: The Barroso, Lennartz, Logue and Adam labs were happy to host the great Senator from Vermont to listen to Jonathan Barra talk about "Role of Iron transporter DMT1 in endosome-mitochondria interaction dynamics in breast cancer cells". This talk was a great start to the imaging meeting 2021 schedule! Great discussion, awesome engagement! Senator, you are always welcome!
01/2021: Congrats to Alena Rudkouskaya and Jason Smith for their manuscript "Quantification of Trastuzumab-HER2 Engagement In Vitro and In Vivo", published in Molecules.
12/15/2020: Jonathan Barra presented his work at Cell Bio Virtual ASCB-EMBO Meeting 2020 on “Role of iron transporter DMT1 in Endosome-mitochondria interactions in breast cancer cells”.
10/16/2020: Jonathan Barra presented his work at East–West Iron Club (EWIC) Virtual Conference on “Role of iron transporter DMT1 in Endosome-mitochondria interactions in breast cancer cells”.
07/25/2020: Congrats to Alena Rudkouskaya for her first-author publication in Theranostics entitled "Multiplexed non-invasive tumor imaging of glucose metabolism and receptor-ligand engagement using dark quencher FRET acceptor", see link
05/26/2020: Welcome to the Barroso lab: Pampa Mandal, a second-year graduate student at AMC.
05/22/2020 (11am ET): Alena Rudkouskaya presented in the Women in Molecular Imaging Webinar Series on "Multiscale Quantification of Target Engagement in Breast Cancer Models Using Fluorescent Lifetime FRET Imaging", Moderator: Edward “Jim” Delikatny, PhD, Research Professor of Radiology University of Pennsylvania. Here is the recording of the webinar.
05/01/2020: With support from a $2.5M grant from the @NIH’s @theNCI, Albany Medical College researcher Margarida Barroso, PhD, is collaborating with engineers from @RPI on a new bioimaging technique. Check the news here.
04/05/2020: Barroso lab welcomes post-doctoral fellow, Jonathan Barra-Carrasco, to Albany and AMC! Lauren Elder has also joined the lab as a research technician.
04/03/2020: Congratulations to Kate Tubbesing, now a post-doctoral fellow at University at Albany, for having her first-author manuscript entitled "Complex Rab4-mediated regulation of endosomal size and EGFR activation" being selected for the cover in the May issue of Molecular Cancer Research.
02/28/2020: The Barroso lab is moving to a larger lab space (MR04) at AMC. Very exciting!02/27/2020: Check this CBS6 Albany story by Lynsey Smith on our "Endosome-mitochondria interactions in breast cancer" NIH grant funding.
02/26/2020: Margarida Barroso will give an invited lecture "Multiscale Imaging of receptor transport: Super-resolution to Optical Imaging" in the NanoBio seminar series at SUNY Polytechnic Institute, Albany, NY.
02/13/2020: Kate Tubbesing PhD defense "Inside-out and outside-in regulation: how transferrin iron-release and Rab4-GTPases influence early endosome dynamics".
02/01-04/2020: The Barroso lab got 4 oral presentations at SPIE Photonics West, San Francisco. Alena Rudkouskaya presented "Quantification of anti-HER2 drug uptake into human breast cancer cells using fluorescence lifetime FRET imaging" on Feb 1st. Then Ling Wang presented "Heterogeneity of mitochondria morphology in breast cancer cells" on Feb 2nd. Margarida Barroso presented "Monitoring receptor-ligand interactions using fluorescence lifetime FRET imaging via deep learning" on Feb 4th. Ting Chean Khoo from the Khmaladze lab (University at Albany) presented his collaborative work with Kate Tubbesing on "Raman hyperspectral imaging of transferrin-bound iron in T47D and MDA-MB-231 breast cancer cells" on Feb 3rd.
01/23/2020: Congratulations to Kate Tubbesing for her first author manuscript entitled "Complex Rab4-mediated regulation of endosomal size and EGFR activation" to be published in Molecular Cancer Research
01/07/2020: Our collaborative work with Dr. Xavier Intes from RPI on Macroscopic Fluorescence Lifetime Imaging that was funded by R01 EB019443 will continue to be supported thanks to a new grant from NCI 1R01CA250636-01: “In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging” (scored at 6%). This is a 4-year effort supported by a $3.1M budget. The work will benefit from a close collaboration with Dr. Xavier Michalet from UCLA and Dr. Pingkun Yan from RPI.
12/2019: Our work on endosome-mitochondria interactions in breast cancer cells was funded by NCI 1R01 CA233188 (scored at 8%). This is a 5-year effort supported by a 2.88M budget. This work will benefit from close collaboration with Dr. DiPersio, Dr. Adam and Dr. Lamar from AMC and Dr. Corr from RPI. See press release from Albany Medical College.