Imaging from cells to animals
October 2023: Margarida and Arun will be representing the Barroso lab in the Joint Meeting of ASMB, HCS, and ASIP: Elevating Science to New Heights, Tissue, Matrix, and Pathobiology, Salt Lake City, Utah | October 22-25, 2023. Margarida will present an invited talk on "Macroscopy FRET FLI Monitors Cancer Antibody Drug-Target Engagement In Vivo" in the SESSION 017: HCS - Cancer: Imaging Immuno-Oncology, Sunday, October 22, 2023. Arun Asif will present a talk on "Biofabricated Microcapsules Facilitate Formation of Matrigel-free 3D Tumor Model Alternatives" in SESSION 069: HCS with IHCS SIG - Organoids and 3-D ModelsTuesday, October 24, 2023. See photos here
September 2023: Arun Asif will be presenting a talk entitled "3D tumor constructs as analytical tools to assess the impact of iron metabolism in cancer invasion" at the Capital District Posdoc Association Symposium.
September 2023: Margarida presented a talk on the organelle topology profiling of metastatic cancer cells using machine learning classification approaches at the NCI Informatics Technology Cancer Research network meeting at the University of Chicago.
September 2023: Margarida Barroso and Javier Bravo-Cordero (Icahn School of Medicine at Mount Sinai, NYC) were awarded a NIH NCI ITCR/IMAT supplement (R21CA274622-02S1) to their respective R21 grants to apply organelle topology machine learning cancer cell classification to dormancy cancer cell models.
September 2023: Congratulations to Joshua Goldwag, 4th year medical student, for successfully defending his MD distinction in research thesis on machine learning-based organelle topology cancer cell classification. Congrats Joshua and good luck with matching in a great residency program!
August 2023: Congratulations to Pampa Mandal for an outstanding defense of her MS thesis on the "Role of Rab4A in inter-organelle interactions and intracellular iron transport in cancerous vs non-cancerous cells"! Congrats Pampa for all your hard work and passion for science!
August 2023: Margarida Barroso and Xavier Intes highlighted their collaboration on the development of macroscopy fluorescence lifetime FRET (MFLI) in vivo imaging to measure target engagement in live, intact tumor xenografts, by co-presenting their work entitled "Biology meets Engineering: Quantifying Drug-target Engagement in Vivo" at FINDING YOUR INNER MODELER, NSF Workshop Year 6, University of Alabama at Birmingham. You can watch the recording here.
August 2023: Congratulations Dr. Verma for the invited oral and poster presentations at the 2023 National Cancer Institute (NCI) Junior Investigator Meeting that will be held at the University of Pennsylvania (UPenn) in Philadelphia, PA on August 17-18, 2023.
July 2023: The latest translational research forum highlighting bench to bedside research took place on Thursday, July 13, from 4 to 5 p.m. in Huyck Auditorium, AMC. Margarida Barroso, PhD, and Sandra Shin, MD, of Albany Medical Center and Xavier Intes, PhD, of RPI, discussed their collaboration that integrates biology, state-of-the-art imaging, engineering, and clinical pathology to tackle new ways to target and treat breast cancer.
July 2023: NIH selected for highlight our recently awarded $3.3 million R01 grant from NCI, in collaboration with the Intes lab, This grant will support the use of artificial intelligence to improve drug therapy for breast cancer treatment.
July 2023: We are very happy to introduce organelle topology and how it can be used as a specific cellular signature to identify and discriminate different cancer cells grown in 2D vs 3D spheroids. Read the paper published in iScience. All this is work from Ling Wang, Joshua Goldwag, and Megan Bouyea, in collaboration with Uwe Kruger and Xavier Intes for the ML/DL work. Thanks also to Jonathan Barra and all the other authors!
June 2023: Very exciting to announce the publication of "In vivo quantitative FRET small animal imaging: Intensity vs. lifetime-based FRET" in Biophysical Reports. Also read about our results shown as cover art for the June 14 issue of the Biophysical Reports on the BPS Blog.
May 2023: Dr. Barroso from Albany Medical College (AMC) and Dr. Intes from Rensselaer Polytechnic Institute (RPI) were awarded a $3.3 million grant over five years by the National Cancer Institute to use artificial intelligence (AI) to improve targeted drug therapy in HER2-positive breast cancer treatment (AMC news).
April 2023: Dr. Barroso and Dr. Corr (RPI) were awarded a 2-year Peter T. Rowley Breast Cancer New York State Research Grant entitled "Bioprinting of histology-grade breast tumor mimics for personalized drug screening".