Pathophysiology of acute and chronic liver disease caused by drug-induced liver disease, metabolic syndrome, alcohol-associated liver and MetALD(metabolic dysfunction and alcohol-associated liver disease) progressing to hepatocellular carcinoma.
Molecular biology, Cellular biology, Cell lines, Primary cells and Mice models.
Research Area:
Key focuses of Laboratory of Immunology, vesicle biology and remodeling (LIVeR)
Deciphering the sequential changes in cellular-immune signaling, extracellular vesicles biogenesis and dynamics to understand the critical tipping points for the progression of fibrosis to cirrhosis and Hepatocellular carcinoma (HCC).
Investigate how the extracellular matrix (ECM) is restructured by cellular-immune signalling, extracellular vesicle cargoes and cellular interactions, creating the pre-metastatic niche.
Harnessing the potential of extracellular vesicles as liquid biopsies and utilizing their property of delivery vehicles to develop targeted therapies.
Understanding how cellular-immune signaling and EVs facilitates multi-organ crosstalk in liver pathogenesis.
➤ Obesity/Metabolic syndrome
➤ Drug-induced Liver Injury (DILI)
➤ Metabolic dysfunction and alcohol associated liver disease (MetALD)
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