PRINCIPAL INVESTIGATOR

CAREER:

2024- Present - Assistant Professor in Dept. of Animal Biology, School of Life Sciences, University of Hyderabad 

2023-2024-   Instructor, Harvard Medical School, Boston, MA, USA 

2023-2024 -  Staff Scientist I,Beth Israel Deaconess Medical Center, Boston, MA, USA 

2019-2023 -  Postdoctoral fellow, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA,USA 

2018-2019 - Postdoctoral fellow, University of Massachusetts Chan Medical School, Worcester, MA, USA 

2010-2016 - PhD from Jawaharlal Nehru University, NewDelhi, India 

HONOUR:

➥Awards

• INSA Medal for young Scientist by Indian National Science Academy (2021)

• AASLD Foundation Abstract Award for presenting in Digestive Disease Week (2022)

• Early-Stage Career Investigator Award by InSPIRE program of Beth Israel Deaconess Medical Center, Boston, USA (2023)

➥Invited Talk

• Invited talk on “Proteomic Profiling of Circulating EVs in Alcoholic Hepatitis identifies Novel Biomarkers” in session “Translational Science Driving clinical impact” at BUILD 4.0, “Building Basics and Exploring Advances in Hepatology,” held on February 7 to 8,at Hotel Aurika, Skycity,Mumbai, India.(2026)

• Oral presentation “Liver fibrosis is exacerbated by alcohol binges in murine NASH via NLRP3-dependent neutrophil extracellular traps formation, which mediates activation of hepatic stellate cells” in AASLD Liver Plenary Session: Novel Insights and Advances in Liver Disease in Digestive Disease Week, 6-9th May 2023, Chicago, USA.(2023)

• Oral presentation “Neutrophil Extracellular Traps Activate Hepatic Stellate Cell and Monocytes via NLRP3 Sensing in Alcohol-Induced Acceleration of NASH Fibrosis” in Gordon Research Conference on Alcohol-Induced End Organ Diseases-Multisystemic Pathophysiological Mechanisms, March 26-31, Ventura, CA, USA. (2023)

• Invited Lecture “Proteomic and small RNA profiling of plasma and extracellular vesicles in alcoholic hepatitis” International Liver Congress, EASL, 2022, 22 -26 June,London, UK. (2022)

• Oral presentation “Impaired autophagosome function and exosome production linked via miR-155 in alcoholic liver disease” 2019 Gordon Research Conference Alcohol and End Organ Injury from March 24- 29,Ventura, CA, USA. (2019)

• Oral Presentation “Recruitment of Arp2/3 complex via EhAK1: Coupling cytoskeleton dynamics to phagocytosis in Entamoeba histolytica” 12th International Conference of Cell Biology held on 21-25th July, Prague, Czech Republic.(2016)

LAB'S VISION:

Babuta lab aims to decipher immune signaling and extracellular vesicle dynamics in liver fibrosis, cirrhosis, and HCC to develop targeted therapies.

LAB HIGHLIGHTS:

• Kumari, N*., Raj, S*. and Babuta, M#  ., 2026. Mitochondrial proteostasis, unfolded protein response, and its relation to cancer. In Proteostasis and Cancer (pp. 79-105). Academic Press. #Corresponding author *Equal contribution 

• Raj, S. and Babuta, M#  ., 2026. Clinical implications of proteostasis in cancer. In Proteostasis  and Cancer (pp. 215-238). Academic Press. #Corresponding author 

• Warhade, A. and Babuta, M # ., 2026. Cathepsin Proteases: Physiological Roles and Implications in Disease Pathophysiology. In Enzyme Based Approaches in Cancer Healthcare Management (pp. 241-264). Singapore: Springer Nature Singapore. #Corresponding author 

• Babuta M, Datta AA, de Carvalho Ribeiro M, Santos, Bruna de Araújo Cardoso dos , Morel C, Copeland C, Ortega-Ribera M, Mehta J, Calenda C, Wang Y, Remotti V, Brezani V, Patel A, Hawryluk D, Szabo G. Cyclic GMP–AMP synthase deficiency predisposes the liver to alcohol- induced cell death and ER stress. Hepatology Communications 10(3):e00908, March 2026. DOI: 10.1097/HC9.0000000000000908 9 

• Osataphan S, Patell R, Babuta M, et al. The efficacy of rosuvastatin to reduce circulating tissue factor extracellular vesicles after ovarian cancer surgery. Blood Adv. 2025;9(17):4472- 4476. doi:10.1182/bloodadvances.2025016107. PMID: 40472284. 

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