Augustine Chimezie Onyema

I am glad to welcome you to my website. Augustine is a computational biochemist who uses in silico tools to understand biochemical processes. Using molecular dynamics and free energy computational techniques, Augustine is currently studying the dynamics of cellular machinery like the nucleosome core particle (NCP) as implicated in different cancer types at Professor Sharon Loverde's Lab in the Chemistry department at the City University of New York-College of Staten Island. Looking point mutations at the histone core of the NCP, Augustine is studying how these mutations affect the stability of the NCP and the corresponding histone DNA interaction. Manuscript for the study will soon be submitted for peer review.

Furthermore, with funding from The Molecular Science Software Institute (MolSSI), Augustine is optimizing two code; to analyze the hydrogen bond dynamics (lifetime) of the hydrogen bonds in proteins and also to compute the kinetic correlation (Conditional Activity) of different domains in biomolecules including the nucleosome and other allosteric proteins.These codes will be made available on our GitHub page once they have gone through the peer review process.

Previously, Augustine has used different docking and chemo-informatics protocols to study the interaction of small molecules against key molecular targets involved in various clinical conditions, including type II diabetes and SARS-Cov2. To acknowledge Augustine achievements, he was spotlighted by the Graduate Center CUNY.