Publications

2022

  • Pramanik N, De T, Sharma P, Alakesh A, Jagirdar SK, Rangarajan A, Jhunjhunwala S. Surface-Coated Cerium Nanoparticles to Improve Chemotherapeutic Delivery to Tumor Cells. ACS omega. 2022 Sep 1;7(36):31651-7.

  • Monika, P., Chandraprabha, M.N., Murthy, K.C., Rangarajan A, Waiker, P.V. and Sathish, M. Human primary chronic wound derived fibroblasts demonstrate differential pattern in expression of fibroblast specific markers, cell cycle arrest and reduced proliferation. Experimental and Molecular Pathology, 2022. p.104803.

  • Andugulapati SB, Sundararaman A, Lahiry M, Rangarajan A. AMP-activated protein kinase promotes breast cancer stemness and drug resistance. Disease Models & Mechanisms. 2022 Jun 1;15(6):dmm049203.

  • Kumar S, Rangarajan A, Pal D. Somatic mutation analyses of stem-like cells in gingivobuccal oral squamous cell carcinoma reveals DNA damage response genes. Genomics. 2022 Mar 1;114(2):110308.

  • Monika P, Chandraprabha MN, Rangarajan A, Waiker PV, Chidambara Murthy KN. Challenges in healing wound: role of complementary and alternative medicine. Frontiers in Nutrition. 2022 Jan 20;8:1198.

  • Bharadwa KR, Dasgupta K, Narayana SM, Ramachandra C, Babu SM, Rangarajan A, Kumar RV. PD-1 and PD-L1 Expression in Indian Women with Breast Cancer. European Journal of Breast Health. 2022 Jan;18(1):21.

  • GK AV, Gogoi G, Behera B, Rila S, Rangarajan A, Pandya HJ. RapidET: a MEMS-based platform for label-free and rapid demarcation of tumors from normal breast biopsy tissues. Microsystems & nanoengineering. 2022 Jan 17;8(1):1-6.

  • Jinagal SL, Shekhar P, Chandra K, Mutnuru SA, Ramanan N, Foretz M, Benoit V, Bhat R, Rangarajan A. Prolactin-induced AMPK stabilizes alveologenesis and lactogenesis through regulation of STAT5 signaling. bioRxiv. 2022 Jan 1

2021

  • Vishnu GA, Sakorikar T, Baby A, Singh C, Rangarajan A, Pandya HJ. Bimodal characterization of breast biopsy tissues using MEMS-based biochips: Toward improved tumor delineation. IEEE Sensors Journal. 2021 Sep 14;21(21):24801-11.

  • Saha M, Deshpande N, Dubey A, Pal D, Atreya HS, Rangarajan A. Sustained AMPK activation and proline metabolism play critical roles in the survival of matrix-deprived transformed cells. Frontiers in cell and developmental biology. 2021 Nov 15:3245.

  • Balachander GM, Kotcherlakota R, Nayak B, Kedaria D, Rangarajan A, Chatterjee K. 3D Tumor Models for Breast Cancer: Whither We Are and What We Need. ACS Biomaterials Science & Engineering. 2021 Jul 21;7(8):3470-86.

  • Monika P, Waiker PV, Chandraprabha MN, Rangarajan A, Murthy KN. Myofibroblast progeny in wound biology and wound healing studies. Wound Repair and Regeneration. 2021 Jul;29(4):531-47.

  • Chedere A, Hari K, Kumar S, Rangarajan A, Jolly MK. (2021). Multi-Stability and Consequent Phenotypic Plasticity in AMPK-Akt Double Negative Feedback Loop in Cancer Cells. Journal of Clinical Medicine, 10(3):472. doi: 10.3390/jcm10030472.

  • Sundararaman A, Saha M, Kumar S, Rangarajan A. Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer. InAnoikis 2021 (pp. 17-50). Springer, Cham.

2020

  • Jia W, Tripathi S, Chakraborty P, Chedere A, Rangarajan A, Levine H, Jolly MK. (2020). Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT. Oncotarget, 11(27):2611-2624. doi: 10.18632/oncotarget.27651

  • Suneet K, De T, Rangarajan A, Jain S. (2020). Magnetic nanofibers based bandage for skin cancer treatment: a non-invasive hyperthermia therapy. Cancer Rep (Hoboken). 3(6):e1281. doi: 10.1002/cnr2.1281.

  • Ranganathan S, Kumar S, Mohanty SS, Jolly MK, Rangarajan A. Cellular Plasticity in Matrix-Attached and-Detached Cells: Implications in Metastasis. Journal of the Indian Institute of Science. 2020 Jul;100(3):525-36.

  • Sundararaman A, Kumar S, Rangarajan A. Adaptive phenotypic switching in breast cancer in response to matrix deprivation. InPhenotypic Switching 2020 Jan 1 (pp. 651-676). Academic Press.

  • Kumar S, Hari K, Jolly MK, Rangarajan A. Feedback loops involving ERK, AMPK and TFEB generate non-genetic heterogeneity that allows cells to evade anoikis. bioRxiv. 2020 Jan 1:736546.

  • Lahiry M, Kumar S, Hari K, Chedere A, Jolly MK, Rangarajan A. AMPK-Fyn signaling promotes Notch1 stability to potentiate hypoxia-induced breast cancer stemness and drug resistance. BioRxiv. 2020 Jan 1:458489.

2019

    • De, T., Goyal, S., Balachander, G., Chatterjee, K., Kumar, P., Babu K., G. and Rangarajan, A. (2019). A Novel Ex Vivo System Using 3D Polymer Scaffold to Culture Circulating Tumor Cells from Breast Cancer Patients Exhibits Dynamic E-M Phenotypes. Journal of Clinical Medicine, 8(9), p.1473. https://doi.org/10.3390/jcm8091473

    • Pramanik, N., Ranganathan, S., Rao, S., Suneet, K., Jain, S., Rangarajan, A. and Jhunjhunwala, S. (2019). A Composite of Hyaluronic Acid-Modified Graphene Oxide and Iron Oxide Nanoparticles for Targeted Drug Delivery and Magnetothermal Therapy. ACS Omega, 4(5), pp.9284-9293. https://doi.org/10.1021/acsomega.9b00870

    • Nayak, B., Balachander, G., Manjunath, S., Rangarajan, A., & Chatterjee, K. (2019). Tissue mimetic 3D scaffold for breast tumor-derived organoid culture toward personalized chemotherapy. Colloids And Surfaces B: Biointerfaces, 180, 334-343. doi: 10.1016/j.colsurfb.2019.04.056

2018

    • Balachander, G., Talukdar, P., Debnath, M., Rangarajan, A., & Chatterjee, K. (2018). Inflammatory Role of Cancer-Associated Fibroblasts in Invasive Breast Tumors Revealed Using a Fibrous Polymer Scaffold. ACS Applied Materials & Interfaces, 10(40), 33814-33826. doi: 10.1021/acsami.8b07609

    • Andrieu, G., Shafran, J., Deeney, J., Bharadwaj, K., Rangarajan, A., & Denis, G. (2018). BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironment. Journal Of Leukocyte Biology, 104(2), 265-274. doi: 10.1002/jlb.5ri0917-380rr

    • Saxena, M., Balaji, S., Deshpande, N., Ranganathan, S., Pillai, D., Hindupur, S., & Rangarajan, A. (2018). AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation. Journal Of Cell Science, 131(14), jcs208314. doi: 10.1242/jcs.208314

    • Saha, M., Kumar, S., Bukhari, S., Balaji, S., Kumar, P., Hindupur, S., & Rangarajan, A. (2018). AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation. Cancer Research, 78(6), 1497-1510. doi: 10.1158/0008-5472.can-17-2090

    • Singh, A., Deshpande, N., Pramanik, N., Jhunjhunwala, S., Rangarajan, A., & Atreya, H. (2018). Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer. Scientific Reports, 8(1). doi: 10.1038/s41598-018-21435-5

    • Lahiry, M., & Rangarajan, A. (2018). AMPK promotes Notch1 stability to potentiate hypoxia-induced breast cancer aggressiveness. doi: 10.1101/458489

2017

    • Balachander, G., Rajashekar, B., M Sarashetti, P., Rangarajan, A., & Chatterjee, K. (2017). MiRNomics Reveals Breast Cancer Cells Cultured on 3D Scaffolds Better Mimic Tumors in Vivo than Conventional 2D Culture. ACS Biomaterials Science & Engineering, 4(1), 116-127. doi: 10.1021/acsbiomaterials.7b00694

2016

    • Pulakkat, S., Balaji, S., Rangarajan, A., & Raichur, A. (2016). Surface Engineered Protein Nanoparticles With Hyaluronic Acid Based Multilayers For Targeted Delivery Of Anticancer Agents. ACS Applied Materials & Interfaces, 8(36), 23437-23449. doi: 10.1021/acsami.6b04179

    • Sundararaman, A., Amirtham, U., & Rangarajan, A. (2016). Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation. Journal Of Biological Chemistry, 291(28), 14410-14429. doi: 10.1074/jbc.m116.731257

    • Balaji, S., Udupa, N., Chamallamudi, M., Gupta, V., & Rangarajan, A. (2016). Role of the Drug Transporter ABCC3 in Breast Cancer Chemoresistance. PLOS ONE, 11(5), e0155013. doi: 10.1371/journal.pone.0155013

    • Chaturvedi, D., Balaji, S., Bn, V., Ariese, F., Umapathy, S., & Rangarajan, A. (2016). Different Phases of Breast Cancer Cells: Raman Study of Immortalized, Transformed, and Invasive Cells. Biosensors, 6(4), 57. doi: 10.3390/bios6040057

2015

    • Balachander, G., Balaji, S., Rangarajan, A., & Chatterjee, K. (2015). Enhanced Metastatic Potential in a 3D Tissue Scaffold toward a Comprehensive in Vitro Model for Breast Cancer Metastasis. ACS Applied Materials & Interfaces, 7(50), 27810-27822. doi: 10.1021/acsami.5b09064

    • Deshpande, N., & Rangarajan, A. (2015). Cancer Stem Cells: Formidable Allies of Cancer. Indian Journal Of Surgical Oncology, 6(4), 400-414. doi: 10.1007/s13193-015-0451-7

2014

    • Maliyakkal, N., Appadath Beeran, A., Balaji, S., Udupa, N., Ranganath Pai, S., & Rangarajan, A. (2014). Effects of Withania somnifera and Tinospora cordifolia Extracts on the Side Population Phenotype of Human Epithelial Cancer Cells. Integrative Cancer Therapies, 14(2), 156-171. doi: 10.1177/1534735414564423

    • Mittal, S., Sharma, A., Balaji, S., Gowda, M., Dighe, R., Kumar, R., & Rangarajan, A. (2014). Coordinate Hyperactivation of Notch1 and Ras/MAPK Pathways Correlates with Poor Patient Survival: Novel Therapeutic Strategy for Aggressive Breast Cancers. Molecular Cancer Therapeutics, 13(12), 3198-3209. doi: 10.1158/1535-7163.mct-14-0280

    • Paranjape, A., Balaji, S., Mandal, T., Krushik, E., Nagaraj, P., Mukherjee, G., & Rangarajan, A. (2014). Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog. BMC Cancer, 14(1). doi: 10.1186/1471-2407-14-785

    • Hindupur, S., Balaji, S., Saxena, M., Pandey, S., Sravan, G., & Heda, N. et al. (2014). Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells. Breast Cancer Research, 16(4). doi: 10.1186/s13058-014-0420-z

2012

    • Arya, N., Sardana, V., Saxena, M., Rangarajan, A., & Katti, D. (2012). Recapitulating tumour microenvironment in chitosan-gelatin three-dimensional scaffolds: an improved in vitro tumour model. Journal Of The Royal Society Interface, 9(77), 3288-3302. doi: 10.1098/rsif.2012.0564

2011

    • Sharma, A., Paranjape, A., Rangarajan, A., & Dighe, R. (2011). A Monoclonal Antibody against Human Notch1 Ligand-Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem-like Cells. Molecular Cancer Therapeutics, 11(1), 77-86. doi: 10.1158/1535-7163.mct-11-0508

    • Paranjape, A., Mandal, T., Mukherjee, G., Kumar, M., Sengupta, K., & Rangarajan, A. (2011). Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties. Oncogene, 31(15), 1896-1909. doi: 10.1038/onc.2011.378

    • Saxena, M., Stephens, M., Pathak, H., & Rangarajan, A. (2011). Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters. Cell Death & Disease, 2(7), e179-e179. doi: 10.1038/cddis.2011.61

2010

2009

    • Mittal, S., Subramanyam, D., Dey, D., Kumar, R., & Rangarajan, A. (2009). Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis. Molecular Cancer, 8(1), 128. doi: 10.1186/1476-4598-8-128

    • Kumar, S., & Rangarajan, A. (2009). Simian Virus 40 Small T Antigen Activates AMPK and Triggers Autophagy To Protect Cancer Cells from Nutrient Deprivation. Journal Of Virology, 83(17), 8565-8574. doi: 10.1128/jvi.00603-09

    • Dey, D., Saxena, M., Paranjape, A., Krishnan, V., Giraddi, R., & Kumar, M. et al. (2009). Phenotypic and Functional Characterization of Human Mammary Stem/Progenitor Cells in Long Term Culture. Plos ONE, 4(4), e5329. doi: 10.1371/journal.pone.0005329

2007

2006

    • Bheeshmachar, G., Purushotaman, D., Sade, H., Gunasekharan, V., Rangarajan, A., & Sarin, A. (2006). Evidence for a Role for Notch Signaling in the Cytokine-Dependent Survival of Activated T Cells. The Journal Of Immunology, 177(8), 5041-5050. doi: 10.4049/jimmunol.177.8.5041

Before 2004

    • Rangarajan, A., Hong, S., Gifford, A., & Weinberg, R. (2004). Species- and cell type-specific requirements for cellular transformation. Cancer Cell, 6(2), 171-183. doi: 10.1016/j.ccr.2004.07.009

    • Veeraraghavalu, K., Pett, M., Kumar, R., Nair, P., Rangarajan, A., Stanley, M., & Krishna, S. (2004). Papillomavirus-Mediated Neoplastic Progression Is Associated with Reciprocal Changes in Jagged1 and Manic Fringe Expression Linked to Notch Activation. Journal Of Virology, 78(16), 8687-8700. doi: 10.1128/jvi.78.16.8687-8700.2004

    • Rangarajan, A., & Weinberg, R. (2003). Comparative biology of mouse versus human cells: modelling human cancer in mice. Nature Reviews Cancer, 3(12), 952-959. doi: 10.1038/nrc1235

    • Rangarajan, A., Syal, R., Selvarajah, S., Chakrabarti, O., Sarin, A., & Krishna, S. (2001). Activated Notch1 Signaling Cooperates with Papillomavirus Oncogenes in Transformation and Generates Resistance to Apoptosis on Matrix Withdrawal through PKB/Akt. Virology, 286(1), 23-30. doi: 10.1006/viro.2001.0867

    • Rangarajan, A. (2001). Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. The EMBO Journal, 20(13), 3427-3436. doi: 10.1093/emboj/20.13.3427

    • Daniel, B., Mukherjee, G., Rangarajan, A., Krishna, S., & Vallikad, E. (1997). The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions. Journal Of General Virology, 78(5), 1095-1101. doi: 10.1099/0022-1317-78-5-1095

    • Deshpande, N., Chopra, A., Rangarajan, A., Shashidhara, L., Rodrigues, V., & Krishna, S. (1997). The Human Transcription Enhancer Factor-1, TEF-1, Can Substitute for Drosophila scalloped during Wing blade Development. Journal Of Biological Chemistry, 272(16), 10664-10668. doi: 10.1074/jbc.272.16.10664