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Principal Investigator
Annapoorni Rangarajan
Education:
PDF at Robert Weinberg's lab, Whitehead Institute for Biomedical research, MIT, USA
Ph.D at National Centre for Biological Sciences, Bangalore, India
M.Sc. from Nagpur University, Maharashtra, India
Email: anu[at]iisc[dot]ac[dot]in
PhD students
Shweta Warrier
Education:
M. Sc. Genetics from the Department of Genetics, Delhi University, India
B. Sc. (Hons) in Biomedical Science from Bhaskaracharya College of Applied Sciences, Delhi University, India. Gold Medalist.
Project:
Cancer cells overcome a multitude of stresses in order to survive and proliferate. One of the ways is by synthesizing certain proteins to help them adapt and survive. Considering that global protein translation shuts down under such stresses, my project involves the investigation into the altered translatome and the mechanism that cancer cells must be employing in order to survive the stress of matrix deprivation.
Year of Joining : August 2017
Email: shwetaw.iisc.ac.in
Tamasa De
Education:
M. Sc.- Zoology (Special paper- Biochemistry and Molecular Biology) from Banaras Hindu University, Varanasi, U.P., India. Gold Medalist. INSPIRE SHE scholar.
B. Sc. - Zoology (Chemistry and Botany) from Bethune College, University of Calcutta, West Bengal, India. INSPIRE SHE scholar.
Project:
I am currently working on Breast cancer patient- derived Circulating Tumor Cells (CTCs). Main aim of this study is to explore the role of CTCs in breast cancer pathogenesis. For that, currently we are aiming to isolate, characterize and enrich CTCs sub-population. Furthermore, we would like to understand the molecular mechanisms of the survival strategy and dormancy in CTCs under matrix deprived condition by proteomics analysis. Significance of this study rely on clinical importance of CTCs as liquid biopsy.
Year of Joining : August 2017
Email: tamasade.iisc.ac.in
Dymphna Joyce John
Education:
M. Sc. (Biotechnology) from Savitribai Phule Pune University, Maharashtra, India
B. Sc. (Microbiology) from St Xavier’s College, Kolkata, West Bengal, India
Project:
I am presently working on exploring the interplay between Twist , a known EMT transcription factor and AMPK, a stress sensor kinase, in the context of Cancer and Development, using Drosophila melanogaster as the model system.
Year of Joining : August 2018.
Email : dymphnajohn.iisc.ac.in
Kailash Chandra Bishnoi
Education:
M. Sc. (Zoology), University of Rajasthan, Jaipur
B. Sc. (Chemistry, Botany and Zoology), University Maharaja College, Jaipur
Project : Investigating the role of AMPK in mammary gland stemness and Involution
Year of Joining: August 2020
Email: kailashc@iisc.ac.in
Arshida M M
Education:
BS-MS degree in Biological sciences from Indian Institute of Science Education and Research, Berhampur
Project: 3D bio-printing of oral cancer cells
Year of Joining : 2022
Email: arshidam@iisc.ac.in
Integrated PhD students
Adersh S Nair
Education:
M.Sc. Biological Sciences, Indian Institute of Science, Bangalore
BSc biotechnology + botany (double core) from SCMS institute Cochin
Project:
Studying normal mammary gland helps to understand the factors which orchestrating breast cancer development. My research interest is to find out the role of AMPK in mammary epithelial cell polarity and metabolism using an integrated omics approach.
Year of Joining : 2022
Email: adershs@iisc.ac.in
Shraddha Sansidha Mohanty
Education:
PMRF Scholar
B. Sc Biochemistry (Hons.), Sri Venkateswara College, University of Delhi, New Delhi, India. Gold Medalist. INSPIRE SHE scholar
Project:
Upon detachment from the extracellular matrix (ECM), normal epithelial cells undergo a kind of programmed cell death. This phenomenon is termed 'anoikis' (Greek word for 'homelessness'). On the other hand, survival under matrix-deprived conditions is an essential prerequisite for successful metastasis of tumor cells. So, how do cancer cells survive in the absence of crucial signals from the extracellular matrix? Using a combination of transcriptomic approaches and standard molecular and cell biological techniques, I am trying to understand the mechanisms of anoikis resistance in breast cancer cells.
Year of Joining : April 2018
Interdisciplinary PhD students
Kishan R. Bharadwaj
Education:
M. Tech. in Biotechnology from NIT Allahabad, India
B. E. in Biotechnology from CMR Institute of Technology, Bangalore, India
Project:
How do co-morbid conditions like diabetes influence the incidence, progression and treatment of breast cancer patients? Are Indians metabolically different from the Western population? How does Metformin (medications for diabetes) influence the incidence and progression of breast cancer?
Year of Joining: August 2017
Email: bharadwajr.iisc.ac.in
Sri Harsha Paladugu
Education :
B Tech (Mechanical Engineering) from Kakatiya University, Warangal, India
Project :
I am currently working on developing an multi-organ-on-chip device to mimic breast cancer metastasis. It would help us identify key drugs which would prevent the formation of secondary tumors. Additionally, I am also working on MEMS-based viscosity sensor for bio-fluids applications. It has the potential as an additional modality for the diagnosis and prognosis of many diseases
Year of Joining : August 2018
Email : paladuguh.iisc.ac.in
Sayoni Maiti
Education :
PMRF scholar
B.Tech. in Biotechnology from Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India
Project :
Metformin is a drug given as the first line of treatment for type 2 diabetes. Metformin reduces blood glucose levels and improves insulin sensitivity. However, Metformin is not able to take away the root cause of the illness: hyperinsulinemia. Hyperinsulinemia is known to increase the incidence of various cancers like breast, oral and ovarian cancers. This intrigues me to decipher the cryptic interface between diabetes and cancer through experimental biology. In addition to experimental approach, I am interested in exploring the abstract idea of mathematical oncology and diabetology by formulating mathematical models which may provide meaningful insights into the above mechanisms.
Year of Joining: August 2020
Email : sayonimaiti[at]iisc[dot]ac[dot]in
Nirbhay Raghav
Education:
B. Tech. from Greater Noida Institute of Technology
Project : Machine learning approaches for breast cancer susceptibility and recurrence prediction
Year of Joining: August 2020
Email: nirbhayr.iisc.ac.in
Postdoctoral Fellows
Amaj Ahmed Laskar
Education:
PhD in Biotechnology from Aligarh Muslim University, Aligarh, India. Topic: "Human Salivary Aldehyde Dehydrogenase: Stability and Characterization of Some Inhibitors and Activators of the Enzyme"
MSc Biotechnology from IBU, AMU, India
BSc. Biochemistry from AMU, India
Project : Aldehyde dehydrogenase as a marker of oral cancer stem cells
Year of Joining : 2019
Email: amaja@iisc.ac.in
Sruthy K S
Education:
PhD in Marine biotechnology from Cochin University of Science &Technology (CUSAT), Kerala, India. Topic: “Antimicrobial Peptides from Marine Crustaceans: Molecular Characterization and Evaluation of Bioactive potential”
M.Sc. Marine Biology from CUSAT, Kerala, India
B.Sc. Biotechnology and Botany from CMS College, Mahatma Gandhi University, India
Project:
I am presently working to understand the functional role of AMP-activated protein kinase (AMPK) in epigenetic regulation of histone modifications in matrix detached oral cancer cells and orospheres (enriched in CSCs) using host lab established Indian origin gingivobuccal oral cancer cell line (OC019). Main objectives include investigation of the effect of gene silencing and activity modulation of AMPK on different histone marks by chromatin immunoprecipitation sequencing (ChIP-Seq). Salient findings from this work will lead to the elucidation of role of AMPK in epigenetic regulation of oral cancer stemness and to identify novel targets for treatment and prognosis.
Year of Joining : September, 2019
Email: sruthyk@iisc.ac.in
M.Sc. students
Satya Divya CH
Education:
BSc Biotechnology, microbiology and chemistry from GITAM University, Visakhapatnam
Project:
Year of Joining : 2022
Email: satyadivyac@iisc.ac.in
Short term project students
Harshitha Ajith
Education:
Msc. Integrated Biotechnology, Vellore Institute of Technology, Tamil Nadu
Project:
Year of Joining : 2022
Email: harshithaajith16@gmail.com
Research Fellows and JRFs
Shivaani Srinivasan
Education:
M. Sc. Biotechnology (5 years integrated) VIT, Vellore, Tamil Nadu, India
Project:
I am working on multiple projects involving oral cancer and breast cancer cell lines, patient tissues and patient-derived tumor cells. Using different immunostaining techniques like immunohistochemistry, immunofluorescence and immunoblotting, I understand the role of AMPK and other key molecular players in the maintenance of breast and oral cancer stemness. I am also studying altered translation under matrix deprivation stress in metastatic breast cancer cells and the influence of type 2 diabetes on breast cancer progression.
Year of Joining : 2021
Email : shivaanis@iisc.ac.in
Secretarial Assistant
Anithalakshmi
Accountant
Lab Attendant
Venu
Associated with the lab for more than 10 years. Plays a vital role in the smooth running of the lab. Responsibilities include arranging sterile glassware and plasticware for tissue culture lab, washing, autoclaving glassware and plasticware for general lab purpose and maintenance of overall cleanliness in the lab.
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