Research
Laboratory Research Area
Our research is in the field of Molecular Enzymology - i.e. the characterization of structure, function and mechanism of enzymes with important biological and biochemical functions. Our lab focuses on the analysis of cofactor-binding proteins; particularly flavoproteins and flavoheme enzymes. Our research involves studies on mammalian proteins, including Nitric Oxide Synthases (NOSs) and Cytochrome P450 reductases (CPR). Flavoproteins represent 1%–3% of all proteins present in prokaryotic and eukaryotic genomes and about half of the proteins involved in electron transfer. In addition, the scope of work extends to learning how other cellular proteins can control the activity of redox enzymes like NOSs, CPR etc. We are also interested in a membrane-associated enzyme NADPH oxidase (NOX) that catalyzes the production of superoxide.
Research Interest
Fascinated by the global health impact of stroke, I am driven by a deep-seated commitment to alleviate its devastating effects. Stroke, a leading cause of disability and mortality worldwide, imposes an immense burden on individuals and society alike. My research interest is firmly rooted in unravelling the intricate molecular mechanisms underlying ischemic stroke, with a focus on the pivotal role of neuronal Nitric Oxide Synthase (nNOS) and its post-translational modification. Ischemic stroke, characterized by disrupted blood flow to the brain, triggers a cascade of cellular events leading to neuronal damage. Through collaborative efforts in molecular enzymology and neurobiology, I aim to elucidate novel therapeutic targets and innovative treatment strategies. Guided by my academic background and research experience, I am poised to embark on this transformative journey towards unravelling the mysteries of stroke pathology.