The laboratory investigates the structure, function and mechanisms of enzymes with important biological and biochemical roles. A central focus is the regulation of cofactor-binding proteins, particularly flavoproteins and flavoheme enzymes involved in redox reactions and electron transfer.
The research programme includes mammalian nitric oxide synthases (NOSs) and cytochrome P450 reductase (CPR), alongside the ways other cellular proteins regulate their activity. It also extends to the membrane-associated enzyme NADPH oxidase (NOX), which catalyses superoxide production.
These studies bring biochemical characterisation together with questions about how enzyme activity is controlled in biological systems.
My research interest centres on the molecular mechanisms of ischemic stroke, with a particular focus on neuronal nitric oxide synthase (nNOS) and its post-translational modification.
How is nNOS activity regulated at the molecular level? How might post-translational changes influence enzyme function in the context of stroke biology? These questions connect my interests in molecular enzymology, neurobiology and biotechnology.
I aim to contribute to a clearer understanding of the molecular events underlying stroke pathology. By studying enzyme regulation and biological mechanisms, my longer-term interest is to help identify questions and potential targets relevant to future therapeutic research.
My training spans molecular biology, protein expression and purification, biochemical assays, microscopy and cell-based methods. This interdisciplinary foundation supports my interest in connecting molecular mechanisms with biological function.