Alachkar Lab

2024

Enhanced T cell activation and cytotoxicity against AML via targeted anti-CD99 nanoparticle treatment PubMed
FLT3/CD99 Bispecific Antibody-Based Nanoparticles for Acute Myeloid Leukemia PubMed
Differences in the mutational landscape of clonal hematopoiesis of indeterminate potential among races and between male and female patients with cancer PubMed
The DNA methylation landscape across the TCR loci in patients with acute myeloid leukemia PubMed

2023

Profiling the epigenetic landscape of the antigen receptor repertoire: the missing epi-immunogenomics data. PubMed
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment. PubMed
Prediction of Peptide and TCR CDR3 Loops in Formation of Class I MHC-Peptide-TCR Complexes Using Molecular Models with Solvation. PubMed
Asparaginase toxicity in Hispanic adult and pediatric patients with acute lymphoblastic leukemia: current understanding. PubMed
Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia. PubMed
Features of the TCR repertoire associate with patients' clinical and molecular characteristics in acute myeloid leukemia. PubMed

2022

CD99 in malignant hematopoiesis. PubMed.
Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia. PubMed

2021

Strategies targeting FLT3 beyond the kinase inhibitors. 2021 March. Pharmacology & Therapeutics. PubMed.
Diversity in immunogenomics: the value and the challenge. PubMed.
Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability. PubMed.
Ancestral diversity is limited in published T cell receptor sequencing studies. PubMed.
Profiling of T Cell Repertoire in SARS-CoV-2-Infected COVID-19 Patients Between Mild Disease and Pneumonia. PubMed.
OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia. PubMed.

2020

Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia. 2020 October. Nanomedicine. NBM.
Deciphering the TCR Repertoire to Solve the COVID-19 Mystery. 2020 June. Trends in Pharmacological Science. Cell.
Apolipoprotein C2 - CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia. 2020 May. Blood Cancer Disc. AACR.
Human Granulocyte-Macrophage Colony-Stimulating Factor Fused to Elastin-Like Polypeptides Assembles Biologically-Active Nanoparticles. 2020 April. Bioconjugate Chem. ACS.

2019

Clinical and preclinical Characterization of CD99 isoforms in acute myeloid leukemia Haematologica. 2019 Aug. PMID: 31371417. PubMed
CD97 expression is associated with poor overall survival in acute myeloid leukemia. Exp Hematol. 2019 Jun. PMID: 31260716 PubMed
The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome. Metabolism Open 2019. Article
Characterization of upregulated adhesion GPCRs in acute myeloid leukemia. Transl Res. 2019 May. PMID: 31153896 PubMed

2018

Midostaurin reduces Regulatory T cells markers in Acute Myeloid Leukemia. Sci Rep. 2018 Dec 03;8(1):17544. PMID: 30510164 View in: PubMed
Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia. Sci Rep. 2018 Sep 05; 8(1):13301. PMID: 30185817. View in: PubMed
Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia. J Transl Med. 2018 Jun 20; 16(1):170. PMID: 29925392. View in: PubMed
The era of immunogenomics/immunopharmacogenomics. J Hum Genet. 2018 May 21. PMID: 29785006. View in: PubMed

2007-2017

Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Pharmacogenomics J. 2017 Jun; 17(3):274-279. PMID: 27019981. View in: PubMed
Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection. BMC Nephrol. 2016 Nov 21; 17(1):181. View in: PubMed
SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells. Oncotarget. 2015 Dec 22; 6(41):43162-71. View in: PubMed
T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia. Oncotarget. 2015 Oct 20; 6(32):33410-25. View in: PubMed
Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL). Transl Oncol. 2015 Oct; 8(5):368-75. View in: PubMed
Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia. Leukemia. 2015 Oct; 29(10):1981-92. View in: PubMed
Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2015 Sep; 50(9):1227-34. View in: PubMed
Deep-sequencing of the T-cell receptor repertoire in patients with haplo-cord and matched-donor transplants. Chimerism. 2015 Jul 3; 6(3):47-9. View in: PubMed
WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck. Mol Cancer Res. 2015 Feb; 13(2):293-304. View in: PubMed
Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia. Oncotarget. 2014 Dec 15; 5(23):12371-82. View in: PubMed
TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22; 6(259):259ra145. View in: PubMed
SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome. J Clin Invest. 2014 Apr 1; 124(4):1512-24. View in: PubMed
Lenalidomide-mediated enhanced translation of C/EBPa-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia. Blood. 2013 Jan 3; 121(1):159-69. View in: PubMed
Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia. J Hematol Oncol. 2013; 6:21. View in: PubMed
Determination of cellular uptake and intracellular levels of Cenersen (Aezea(®), EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells. J Pharm Biomed Anal. 2012 Dec; 71:228-32. View in: PubMed
Nicotinic a5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms. Eur J Hum Genet. 2011 Jan; 19(1):76-83. View in: PubMed
Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues. Neurosci Lett. 2008 Dec 19; 448(1):120-4. View in: PubMed
Skin penetration and lag times of neat and aqueous diethyl phthalate, 1,2-dichloroethane and naphthalene. Cutan Ocul Toxicol. 2007; 26(2):147-60. View in: PubMed

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2024

2023

2022

CD99 in malignant hematopoiesis. PubMed.

Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia. PubMed

2021

Strategies targeting FLT3 beyond the kinase inhibitors. 2021 March. Pharmacology & Therapeutics. PubMed.

Diversity in immunogenomics: the value and the challenge. PubMed.

Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability. PubMed.

Ancestral diversity is limited in published T cell receptor sequencing studies. PubMed.

Profiling of T Cell Repertoire in SARS-CoV-2-Infected COVID-19 Patients Between Mild Disease and Pneumonia. PubMed.

OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia. PubMed.

2020

Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia. 2020 October. Nanomedicine. NBM.

Deciphering the TCR Repertoire to Solve the COVID-19 Mystery. 2020 June. Trends in Pharmacological Science. Cell.

Apolipoprotein C2 - CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia. 2020 May. Blood Cancer Disc. AACR.

Human Granulocyte-Macrophage Colony-Stimulating Factor Fused to Elastin-Like Polypeptides Assembles Biologically-Active Nanoparticles. 2020 April. Bioconjugate Chem. ACS.

2019

Clinical and preclinical Characterization of CD99 isoforms in acute myeloid leukemia Haematologica. 2019 Aug. PMID: 31371417. PubMed

CD97 expression is associated with poor overall survival in acute myeloid leukemia. Exp Hematol. 2019 Jun. PMID: 31260716 PubMed

The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome. Metabolism Open 2019. Article

Characterization of upregulated adhesion GPCRs in acute myeloid leukemia. Transl Res. 2019 May. PMID: 31153896 PubMed

2018

Midostaurin reduces Regulatory T cells markers in Acute Myeloid Leukemia. Sci Rep. 2018 Dec 03;8(1):17544. PMID: 30510164 View in: PubMed

Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia. Sci Rep. 2018 Sep 05; 8(1):13301. PMID: 30185817. View in: PubMed

Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia. J Transl Med. 2018 Jun 20; 16(1):170. PMID: 29925392. View in: PubMed

The era of immunogenomics/immunopharmacogenomics. J Hum Genet. 2018 May 21. PMID: 29785006. View in: PubMed

2007-2017

Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Pharmacogenomics J. 2017 Jun; 17(3):274-279. PMID: 27019981. View in: PubMed

Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection. BMC Nephrol. 2016 Nov 21; 17(1):181. View in: PubMed

SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells. Oncotarget. 2015 Dec 22; 6(41):43162-71. View in: PubMed

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia. Oncotarget. 2015 Oct 20; 6(32):33410-25. View in: PubMed

Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL). Transl Oncol. 2015 Oct; 8(5):368-75. View in: PubMed

Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia. Leukemia. 2015 Oct; 29(10):1981-92. View in: PubMed

Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2015 Sep; 50(9):1227-34. View in: PubMed

Deep-sequencing of the T-cell receptor repertoire in patients with haplo-cord and matched-donor transplants. Chimerism. 2015 Jul 3; 6(3):47-9. View in: PubMed

WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck. Mol Cancer Res. 2015 Feb; 13(2):293-304. View in: PubMed

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia. Oncotarget. 2014 Dec 15; 5(23):12371-82. View in: PubMed

TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22; 6(259):259ra145. View in: PubMed

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome. J Clin Invest. 2014 Apr 1; 124(4):1512-24. View in: PubMed

Lenalidomide-mediated enhanced translation of C/EBPa-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia. Blood. 2013 Jan 3; 121(1):159-69. View in: PubMed

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia. J Hematol Oncol. 2013; 6:21. View in: PubMed

Determination of cellular uptake and intracellular levels of Cenersen (Aezea(®), EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells. J Pharm Biomed Anal. 2012 Dec; 71:228-32. View in: PubMed

Nicotinic a5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms. Eur J Hum Genet. 2011 Jan; 19(1):76-83. View in: PubMed

Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues. Neurosci Lett. 2008 Dec 19; 448(1):120-4. View in: PubMed

Skin penetration and lag times of neat and aqueous diethyl phthalate, 1,2-dichloroethane and naphthalene. Cutan Ocul Toxicol. 2007; 26(2):147-60. View in: PubMed