・Hiratsuka D, Matsuo M, Ishizawa C, Fukui Y, Aikawa S, Hiraoka T, Makabe T, Izumi G, Harada M, Hirota Y.

Increased risk of thromboembolism in adenomyosis: a case-control study.

Reprod Biomed Online. 2026 Apr 2;53(2):105699. 

・He X, Aikawa S, Fukui Y, Ishizawa C, Shimizu-Hirota R, Hiratsuka D, Hiraoka T, Matsuo M, Hirota Y.
TAZ integrates ECM remodeling with uterine stromal differentiation to maintain early pregnancy.

Proc Natl Acad Sci U S A. 2026 May 26;123(21):e2528309123. 

・Kaku T, Aikawa S, Kano K, Okudaira M, Fukui Y, Ishizawa C, Aoki J, Hirota Y.
Activation of the lysophosphatidic acid-Lpar3 axis contributes to platelet-rich plasma-induced decidualization.

Mol Hum Reprod. 2026 Apr 11;32(2):gaag022.

・Ishizawa C, Hiraoka T, Aikawa S, He X, Hiratsuka D, Fukui Y, Matsuo M, Makabe T, Izumi G, Harada M, Wada-Hiraike O, Hirota Y.
Three-dimensional characterization of adenomyosis in female mice: Toward a novel system for drug efficacy evaluation.

J Endocr Soc. 2026 Mar 17;10(5):bvag056. 

・Aikawa S, Shimizu-Hirota R, Sakashita A, He X, Hiratsuka D, Ishizawa C, Iida R, Fukui Y, Hiraoka T, Matsuo M, Takeda N, Ikawa M, Osuga Y, Hirota Y.
HIF2α-induced lysyl oxidase safeguards successful pregnancy by remodelling collagens at the feto-maternal interface.

Cell Death Dis. 2026 Mar 9;17(1):250. 

・Hiratsuka D, Noda K, Yoshida K, Kinoshita M, Doi Y, Kato O, Oshima K, Aikawa S, Ishizawa C, Fukui Y, Hiraoka T, Matsuo M, Makabe T, Izumi G, Sone K, Harada M, Hirota Y.

Utilizing Artificial Intelligence in Cine Magnetic Resonance Imaging Analysis: A Promising Approach for Assessment of Uterine Factors and Prediction of Pregnancy Outcomes in Patients With Recurrent Implantation Failure.

Reprod Med Biol. 2026 Mar 2;25(1):e70028. 

・Sugimoto Y, Aikawa S, Inazumi T, Hirota Y.
Roles of prostaglandin signaling in implantation and decidualization.

Prog Lipid Res. 2025 Nov;100:101357. 

・Hiraoka T, Aikawa S, Mashiko D, Nakagawa T, Shirai H, Hirota Y, Kimura H, Ikawa M.
An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling.

Nat Commun. 2025 Jul 1;16(1):5755. 

・Hiratsuka D, Matsuo M, Ishizawa C, Fukui Y, Hiraoka T, Aikawa S, Izumi G, Harada M, Wada-Hiraike O, Osuga Y, Hirota Y.
Prognostic factors of progesterone resistance in symptomatic adenomyosis: impact of lesion localization on treatment outcome of levonorgestrel intrauterine system.

BMC Womens Health. 2025 Jun 13;25(1):286. 

・Hiratsuka D, Matsuo M, Kashiwabara K, Inoue M, Ishizawa C, Iida R, Fukui Y, Aikawa S, Hiraoka T, Harada M, Wada-Hiraike O, Osuga Y, Hirota Y.
Comparison of diagnostic tests for chronic endometritis and endometrial dysbiosis in recurrent implantation failure: Impact on pregnancy outcomes.

Sci Rep. 2025 Mar 10;15(1):8272. 

・Aikawa S, Hiraoka T, Matsuo M, Fukui Y, Fujita H, Saito-Fujita T, Shimizu-Hirota R, Takeda N, Hiratsuka D, He X, Ishizawa C, Iida R, Akaeda S, Harada M, Wada-Hiraike O, Ikawa M, Osuga Y, Hirota Y.
Spatiotemporal functions of leukemia inhibitory factor in embryo attachment and implantation chamber formation.

Cell Death Discov. 2024 Nov 25;10(1):481. 

・Aikawa S, Matsuo M, Akaeda S, Sugimoto Y, Arita M, Isobe Y, Sugiura Y, Taira S, Maeda R, Shimizu-Hirota R, Takeda N, Hiratsuka D, He X, Ishizawa C, Iida R, Fukui Y, Hiraoka T, Harada M, Wada-Hiraike O, Osuga Y, Hirota Y.
Spatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice.

JCI Insight. 2024 Aug 27;9(19):e181865. 

・Sakamoto R, Fujiwara T, Kawano Y, Aikawa S, Inazumi T, Nakayama O, Kawasaki-Shirata Y, Hashimoto-Iwasaki M, Sugimoto T, Tsuchiya S, Nakao S, Takeo T, Hirota Y, Sugimoto Y.
Uterine prostaglandin DP receptor-induced upon implantation contributes to decidualization together with EP4 receptor.

J Lipid Res. 2024 Oct;65(10):100636. 

・Kobayashi R, Tajika Y, Kohmaru J, Morita S, Horii T, Mizukami Y, Aikawa S, Hirota Y, Hatada I.
The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells.

Cell Death Discov. 2024 Aug 8;10(1):357. 

・Aikawa S, Hirota Y.
Roles of lipid mediators in early pregnancy events.

Reprod Med Biol. 2024 Jul 15;23(1):e12597. 

・Akaeda S, Aikawa S, Hirota Y.
Spatial and molecular anatomy of the endometrium during embryo implantation: a current overview of key regulators of blastocyst invasion.

FEBS J. 2024 Oct;291(19):4206-4221. 

・Fukui Y, Hirota Y, Aikawa S, Sakashita A, Shimizu-Hirota R, Takeda N, Ishizawa C, Iida R, Kaku T, Hirata T, Hiraoka T, Akaeda S, Matsuo M, Osuga Y.
The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion.

Cell Death Dis. 2023 May 18;14(5):320. 

・Hiratsuka D, Aikawa S, Hirota Y, Fukui Y, Akaeda S, Hiraoka T, Matsuo M, Osuga Y.
DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice.

Reprod Sci. 2023 Feb;30(2):494-525. 

・Aikawa S, Hirota Y, Fukui Y, Ishizawa C, IIda R, Kaku T, Hirata T, Akaeda S, Hiraoka T, Matsuo M, Osuga Y.
A gene network of uterine luminal epithelium organizes mouse blastocyst implantation.

Reprod Med Biol. 2022 Jan 5;21(1):e12435.

・Hiraoka T, Hirota Y, Aikawa S, Iida R, Ishizawa C, Kaku T, Hirata T, Fukui Y, Akaeda S, Matsuo M, Shimizu-Hirota R, Takeda N, Osuga Y.
Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females.

Endocrinology. 2022 May 1;163(5):bqac044. 

・Fukui Y, Hirota Y, Aikawa S, Ishizawa C, Iida R, Kaku T, Hirata T, Akaeda S, Hiraoka T, Matsuo M, Osuga Y.
Uterine Receptivity is Reflected by LIF Expression in the Cervix.

Reprod Sci. 2022 May;29(5):1457-1462. 

・Fukui Y, Hirota Y, Saito-Fujita T, Aikawa S, Hiraoka T, Kaku T, Hirata T, Akaeda S, Matsuo M, Shimizu-Hirota R, Takeda N, Ikawa M, Osuga Y.
Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment.

Endocrinology. 2021 Nov 1;162(11):bqab169.

・Akaeda S, Hirota Y, Fukui Y, Aikawa S, Shimizu-Hirota R, Kaku T, Gebril M, Hirata T, Hiraoka T, Matsuo M, Haraguchi H, Saito-Kanatani M, Takeda N, Fujii T, Osuga Y.

Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion.

EMBO Rep. 2021 Feb 3;22(2):e50927. 

・Gebril M, Hirota Y, Aikawa S, Fukui Y, Kaku T, Matsuo M, Hirata T, Akaeda S, Hiraoka T, Shimizu-Hirota R, Takeda N, Taha T, Balah OA, Elnoury MAH, Fujii T, Osuga Y.
Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation.

Endocrinology. 2020 Dec 1;161(12):bqaa195. 

・Aikawa S, Yuan J, Dewar A, Sun X, Dey SK.

Scribble promotes alveologenesis in the pregnant mammary gland for milk production.

Reproduction. 2020 May;159(6):719-731. 

・Yuan J, Aikawa S, Deng W, Bartos A, Walz G, Grahammer F, Huber TB, Sun X, Dey SK.
Primary decidual zone formation requires Scribble for pregnancy success in mice.

Nat Commun. 2019 Nov 28;10(1):5425. 

・Aikawa S, Deng W, Liang X, Yuan J, Bartos A, Sun X, Dey SK.
Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes.

Cell Death Differ. 2020 May;27(5):1489-1504.

・Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, Hirota Y, Fujii T, Tsuchiya S, Taketomi Y, Sugimoto Y, Murakami M, Arita M, Kurano M, Ikeda H, Yatomi Y, Chun J, Aoki J.
Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.

EMBO J. 2017 Jul 14;36(14):2146-2160.

・ Aikawa S, Kano K, Inoue A, Aoki J.

Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling.

Biochem Biophys Res Commun. 2017 

・Aikawa S, Hashimoto T, Kano K, Aoki J.
Lysophosphatidic acid as a lipid mediator with multiple biological actions.
J Biochem. 2015 Feb;157(2):81-9.