Published Studies

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Prus AJ, Van Fossen MT, Iannucci AN, Dalton AG,  and Prete, J. N. (2024). Discriminative stimulus properties of two training doses of gabapentin in rats: Substitution by pregabalin, diazepam, and pentobarbital. Experimental and Clinical Psychopharmacology. Advance online publication. https://doi.org/10.1037/pha0000704

Park M and Prus AJ (2023). Lack of sex and estrous stage effects on compulsive behavior assessed using a schedule-induced polydipsia procedure in rats. Behavioural Pharmacology, 34, 236-244. DOI: 10.1097/FBP.0000000000000723

Lynch CJ and Prus AJ (2021). Assessment of antidepressant-like effects of dextromethorphan on differential reinforcement of low rate 72 second performance in rats. Behavioural Pharmacology, 32, 549-560. DOI: 10.1097/FBP.0000000000000649

Carey LM, Rice RJ, and Prus AP (2017). The neurotensin NTS1 receptor agonist PD149163 produces antidepressant-like effects in the forced swim test: Further support for neurotensin as a novel pharmacologic strategy for antidepressant drugs. Drug Development Research, 78, 196-202. DOI: 10.1002/ddr.21393

Steele III FF, Whitehouse SC, Aday JS, and Prus AJ (2017) Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats. Brain Research, 1658, 31-35. http://dx.doi.org/10.1016/j.brainres.2017.01.012

Prus AJ, Wise LE, Pehrson AL, Philibin SD, Bang-Andersen B, Arnt J, and Porter JH (2016) Discriminative stimulus properties of 1.25 mg/kg clozapine in rats:  mediation by serotonin 5-HT2 and dopamine D4 receptors. Brain Research, 1648, 298-305.

Prus AJ, Mooney-Leber SM, Berquist II MD, Pehrson AL, Porter HP, and Porter JH (2015) The antidepressant drugs fluoxetine and duloxetine produce anxiolytic-like effects in a schedule-induced polydipsia paradigm in rats: enhancement of fluoxetine’s effects by the α2 adrenoceptor antagonist yohimbine. Behavioural Pharmacology, 26, 489-494.

Hillhouse TM, Shankland Z, Matazel KS, Keiser AA, and Prus AJ (2014) The quetiapine active metabolite N-Desalkylquetiapine and the neurotensin NTS1 receptor agonist PD149163 exhibit antidepressant-like effects on operant responding in male rats. Experimental and Clinical Psychopharmacology, 22, 548-556.

Keiser AA, Matazel KS, Esser MK, Feifel D, and Prus AJ (2014) Systemic administration of the neurotensin NTS1receptor agonist PD149163 improves performance on a memory task in naturally deficient male Brown Norway rats.  Experimental and Clinical Psychopharmacology, 22, 541-547.

Prus AJ, Schuck CJ, Rusch KR, and Carey LM (2014)  The discriminative stimulus effects of the neurotensin NTS1receptor agonist PD149163 in rats:  Stimulus generalization testing with dopamine D1 and D2 receptor ligands.  Drug Development Research, 75, 47-58

Prus AJ, Hillhouse TM, and LaCrosse AL (2014) Acute, but not repeated, administration of the neurotensin NTS1receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats.  Progress in Neuro-Psychopharmacology & Biological Psychiatry, 49, 78-84

Hillhouse, TM and Prus AJ (2013) Effects of the neurotensin NTS1 receptor agonist PD149163 on visual signal detection in rats.  European Journal of Pharmacology, 721, 201-207

Berquist II MD, Mooney-Leber SM, Feifel D, Prus AJ (2013) Assessment of attention in male and female Brattleboro rats using a self-paced five-choice serial reaction time task. Brain Research, 1537, 174-179

Holly EN, Ebrecht B, and Prus AJ  (2011) The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats. European Neuropsychopharmacology, 21, 526-531

Jacobson SM and Prus AJ (2010).  Evaluation of the effects of α2 adrenoceptor antagonism with the D2 receptor antagonist raclopride on conditioned avoidance responding in rats.  Behavioural Pharmacology, 21, 654-659

Prus AJ, Zornio PA, Schuck CJ, Heerts T, Jacobson SM and Winiarski DA (2010). The discriminative stimulus properties of idazoxan: mediation by both α2 adrenoceptor antagonism and 5-HT1A receptor agonism. Drug Development Research, 71, 261-267

Li Z, Prus AJ, Dai J, Huang M, and Meltzer (2009) Effects of prefrontal cortical M1 and 5-HT1A receptors on atypical antipsychotic drug-induced dopamine efflux in the prefrontal cortex. Journal of Pharmacology and Experimental Therapeutics, 330, 948-955

Philibin SD, Walentiny MD, Vunck S, Prus AJ, Meltzer HY and Porter JH (2009). Further Characterization of the Discriminative Stimulus Properties of Clozapine in C57BL/6 mice: Mediation about serotonin2A and noradrenergic alpha2 receptors and the clozapine metabolite N-Desmethylclozapine. Psychopharmacology, 203, 303-315

Prus AJ, Pehrson AL, Philibin SD, Wood JT, Vunck SA, and Porter JH (2009). The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats. Psychopharmacology, 203, 295-301

Prus AJ, Vann RE, Rosecrans JA, James JR, Pehrson AL, O’Connel MM, Philibin SD, and Robinson SE (2008) Acute nicotine reduces and repeated nicotine increases spontaneous activity Pharmacology, Biochemistry and Behavior, 91, 150-154

Prus AJ, Maxwell AT, Baker KM, Rosecrans JA, and James JR (2007). Acute behavioral tolerance to nicotine in the conditioned taste aversion paradigm. Drug Development Research, 68, 522-528

Prus AJ, Huang M, Li Z, Dai J, and Meltzer HY (2007). Systemically administered NT69L, a neurotensin receptor agonist, enhances medial prefrontal cortical dopamine and acetylcholine efflux: potentiation of risperidone-, but not haloperidol-, induced dopamine efflux. Brain Research, 1184, 354-364

Li Z, Bonhaus DW, Huang M, Prus AJ, Dai J, and Meltzer HY (2007). AC260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus. European Journal of Pharmacology, 572, 129-137

Li Z, Huang M, Prus AJ, Dai J, Meltzer HY (2007). 5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus. Brain Research, 1134, 70-78

Prus AJ, Philibin SD, Pehrson AL, and Porter JH (2006). The discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25 mg/kg clozapine vs. 5.0 mg/kg clozapine vs. vehicle in a three-choice drug discrimination task. Behavioural Pharmacology, 17, 185-194.

Li Z, Ichikawa J, Huang M, Prus AJ, Dai J and Meltzer HY (2005) ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens.  Psychopharmacology, 183, 144-153

Prus AJ, Philibin SD, Pehrson AL, Cooper RN, and Porter JH (2005). Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination task. Behavioural Pharmacology, 16, 511-520

Philibin SD, Prus AJ, Pehrson AL, and Porter JH (2005) Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice. Psychopharmacology, 180, 49-56.

Prus AJ, Philibin SD, Pehrson AL, Stephens CL, Cooper RN, Wise LE, and Porter JH (2005). Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two-choice drug discrimination task. Drug Development Research, 64, 55-66.

Porter JH, Prus AJ, Varvel SA, and Vann RE (2005). Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats. Psychopharmacology, 178, 67-77.

Prus AJ, Baker LE, and Meltzer HY (2004). Discriminative stimulus properties of 1.25 mg/kg and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin and muscarinic receptor mechanisms. Pharmacology Biochemistry and Behavior, 77, 199-208.

Baker LE and Prus AJ  (2002)  Reevaluation of PNU-99194A discriminative stimulus effects: potentiation by both a D2 antagonist and a D3/D2 agonist. Pharmacology, Biochemistry and Behavior, 73, 753-758.

Goudie AJ, Baker LE, Smith JA, Prus AJ, Svensson K.A., Cortes-Burgos LA, Wong EHF, and Haadsma-Svensson SR (2001) Stimulus properties of clozapine and the putative selective D3 antagonist PNU 99194A: Lack of evidence for mediation of either stimulus by D3 receptors. Behavioural Pharmacology, 12, 303-31