Publications
2024
1) Yuta Kikuchi, Mariko Yoshida, Asaomi Kuwae, Yukihiro Asami, Yuki Inahashi, Akio Abe: Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes, The Journal of Antibiotics, 2024
https://doi.org/10.1038/s41429-024-00715-5
blaIMP-1によってコードされる伝達性カルバペネム耐性遺伝子は、1988年に富山県の病院から分離された緑膿菌GN17203ではじめて報告され、その後、blaIMP-1はエンテロバクター属を含む他の細菌でも検出されるようになりました。現在、多くのblaIMPのバリアントが存在しており、また、blaIMPプロモーターの点変異がプロモーター強度を変化させることが報告されております。緑膿菌GN17203で最初に報告されたblaIMP-1のプロモーター（Pc）は、発現強度が低いプロモーター（PcW）でした。本研究ではプロモーター領域の点変異は、抗菌薬選択圧のもとで強力なプロモーターの方向へとシフトしていくのかを調べました。バイオインフォマティクスの手法を用いてPseudomonadota門の14,529のゲノムデータから115のblaIMPを抽出しマルチプルアラインメント解析を行いました。抽出した115個のblaIMPのプロモーター解析の結果、そのほとんどがクラス1インテグロンに位置するPcを利用していました（n = 112, 97.4%）。年代別ごとにプロモーターを解析した結果、強力なプロモーターであるPcSを持つblaIMP集団の出現は一過性であることが明らかになりました。一方、PcWにTGn拡張型の-10モチーフを獲得した中程度のプロモーター強度を持つPcW-TG集団は、徐々に世界中に広がっていることが明らかになりました。Pcプロモーター強度とIntl1インテグラーゼの切断効率のあいだには逆相関があることが報告されております（切断効率が落ちるとblaIMPの伝播効率が低下します）。このようなトレードオフの関係から強力なプロモーターを持つblaIMPが急速に拡散する可能性は低いということが示唆されました。その一方で、他のインテグロンを利用することでプロモーター強度が増加する可能性は否定できません。プロモーター解析を含むblaIMP遺伝子のモニタリングは今後も必要であると考えております。
2022
1) Yuta Kikuchi, Hidehito Matsui, Yukihiro Asami, Asaomi Kuwae, Yuki Inahashi, Hideaki Hanaki, Akio Abe:
Landscape of blaNDM genes in Enterobacteriaceae, The Journal of Antibiotics, 75:559-566, 2022 more info.
2) Aoi Kimishima, Daichi Hagimoto, Masako Honsho, Yoshihiro Watanabe, Masato Iwatsuki, Hayama Tsutsumi, Yuki Inahashi, Kamrun Naher, Kazunari Sakai, Asaomi Kuwae, Akio Abe, Yukihiro Asami:
Insights into the structure-activity relationship of a type III secretion system inhibitor, aurodox, Bioorganic & medicinal chemistry letters, 69:128779-128779, 2022 more info.
3) Masataka Goto , Akio Abe, Tomoko Hanawa, Masato Suzuki, Asaomi Kuwae:
Bcr4 is a chaperone for the inner rod protein in the Bordetella type III secretion system, Bioorganic & medicinal chemistry letters, 10: e0144322, 2022 more info.
2020
1) Ichiro Takahashi, Koji Hosomi, Takahiro Nagatake, Hirokazu Toubou, Daiki Yamamoto, Ikue Hayashi, Yosuke Kurashima, Shintaro Sato, Naoko Shibata, Yoshiyuki Goto, Fumito Maruyama, Ichiro Nakagawa, Asaomi Kuwae, Akio Abe, Jun Kunisawa and Hiroshi Kiyono:
Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia, international immunology, 32(2):133-141, 2020 more info.
doi: 10.1093/intimm/dxz071
2) Masataka Goto, Tomoko Hanawa, Akio Abe and Asaomi Kuwae:
Transcriptional Downregulation of a Type III Secretion System under Reducing Conditions in Bordetella pertussis, Journal of Bacteriology, 202(21):e00400-20, 2020 more info.
doi: 10.1128/JB.00400-20
2018
1) Cameron S. Runte, Umang Jain, Landon J. Getz, Sabrina Secord, Asaomi Kuwae, Akio Abe, Jason J. LeBlanc, Andrew W. Stadnyk, James B. Kaper, Anne-Marie Hansen and Nikhil A. Thomas:
Tandem tyrosine phosphosites in the Enteropathogenic Escherichia coli chaperone CesT are required for differential type III effector translocation and virulence, Molecular Microbiology, 108(5):536-550, 2018 more info.
doi: 10.1111/mmi.13948
2) Ryutaro Nishimura Akio Abe Yusuke Sakuma Asaomi Kuwae:
Bordetella bronchiseptica Bcr4 antagonizes the negative regulatory function of BspR via its role in type III secretion, Microbiology and Immunology, 62(12):743-754, 2018 more info.
doi: 10.1111/1348-0421.12659
2017
1) Akio Abe, Ryutaro Nishimura and Asaomi Kuwae:
Bordetella effector BopN is translocated into host cells via its N-terminal residues, Microbiol Immunol 61(6): 206–214, 2017 more info.
doi: 10.1111/1348-0421.12489
2) オートファジー「分子メカニズムの理解から病態の解明まで」監修：大隅良典 (単行本) 南山堂, 2017 （12章 ゼノファジー：病原体の排除システム 執筆者：阿部章夫）
2016
1) Asaomi Kuwae, Fumitaka Momose, Kanna Nagamatsu, Yasuharu Suyama, Akio Abe:
BteA secreted from the Bordetella bronchiseptica type III secetion system induces necrosis through an actin cytoskeleton signaling pathway and inhibits phagocytosis by macrophages, PLoS ONE, 11(1): e0148387, 2016 more info.
doi:10.1371/journal.pone.0148387
2) Yan Liub, Ding Zhanga, Åke Engströmc, Gábor Merényia, Matthias Hagnera, Hairu Yanga, Asaomi Kuwae, Yi Wana, Mikael Sjölindera, Hong Sjölindera:
Dynamic niche-specific adaptations in Neisseria meningitidis during infection, Microbes and Infection, 18(2): 109–117, 2016 more info.
doi:10.1016/j.micinf.2015.09.025
3) Jakob Engman, Aurel Negrea, Sara Sigurlásdóttir, Miriam Geörg, Jens Eriksson, Olaspers Sara Eriksson, Asaomi Kuwae, Hong Sjölinder, Ann-Beth Jonsson:
Neisseria meningitidis polynucleotide phosphorylase affects aggregation, adhesion and virulence, Infection and Immunity, 84(4): 01463-15, 2016 more info.
doi:10.1128/IAI.01463-15
4) 桑江朝臣, 阿部章夫:
百日咳菌の細菌学的特徴と病原性因子, 臨床検査 (医学書院), 60(7): 736-741, 2016
2015
1) 阿部章夫, 桑江朝臣:
百日咳菌の分泌装置：病原性発揮のメカニズム, 臨床とウイルス, 43(1): 23-29, 2015 more info.
doi:10.1371/journal.pone.0148387
2) Akio Abe, Ryutaro Nishimura, Naomichi Tanaka, Jun Kurushima, Asaomi Kuwae:
The Bordetella secreted regulator BspR is translocated into the nucleus of host cells via its N-terminal moiety: Evaluation of bacterial effector translocation by the Escherichia coli type III secretion system, PLoS ONE, 10: e0135140, 2016 more info.
doi:10.1371/journal.pone.0135140
3) 阿部章夫
感染症の最前線： 細菌の免疫回避と高病原性獲得の機構, 実験医学, 33(17): 102-109, 2015 more info.
ISBN 978-4-7581-0350-3
2014
1) 桑江朝臣, 阿部章夫:
百日咳菌の細菌学的特徴, 感染症内科, 2(3): 342-350, 2104
2) 阿部章夫:
百日咳, 臨床と微生物, 41(1): 32-38, 2014
3) 阿部章夫:
もっとよくわかる！ 感染症 (単行本), 羊土社, 2014 [中身・正誤表はコチラをご覧ください]
4) Keisuke Okada, Yoshitoshi Ogura, Tetsuya Hayashi, Akio Abe, Asaomi Kuwae, Yasuhiko Horiguchi, Hiroyuki Abe:
Complete Genome Sequence of Bordetella bronchiseptica S798, an isolate from a pig with atrophic rhinitis, Genome Announcements, 2: e00436-14, 2014
doi: 10.1128/genomeA.00436-14
2012
1) Jun Kurushima, Asaomi Kuwae, Akio Abe:
The type III secreted protein BspR regulates the virulence genes in Bordetella bronchiseptica, PLoS ONE, 7(6): e38925, 2012
doi:10.1371/journal.pone.0038925
2) Jun Kurushima, Asaomi Kuwae, Akio Abe:
Btc22 chaperone is required for secretion and stability of the type III secreted protein Bsp22 in Bordetella bronchiseptica, FEMS Microbiol. Lett., 331: 144-151, 2012
doi: 10.1111/j.1574-6968.2012.02561.x
3) Jun Kurushima, Asaomi Kuwae, Akio Abe:
Iron starvation regulates the type III secretion system in Bordetella bronchiseptica, Microbiology and Immunology, 56: 356-362, 2012
doi: 10.1111/j.1348-0421.2012.00442.x
4) Toshio Fukasawa, Akio Abe, Atsusi Nakamura, Miyako Horigome, Akira Naito:
Solid-state NMR spectroscopy reveals anomer specific transport of galactose in the milk yeast Kluyveromyces lactis, FEMS Yeast Res., 12: 415-422, 2012
doi: 10.1111/j.1567-1364.2012.00788.x
2011
1) 阿部章夫，桑江朝臣:
病原細菌のエフェクターの分泌機構と病原性発揮の分子機構, 感染 炎症 免疫, 41: 2-11, 2011
2) Hyun-Ja Han, Asaomi Kuwae, Akio Abe, Yoshichika Arakawa, Kazunari Kamachi:
Differential expression of type III effector BteA protein due to IS481 Insertion in Bordetella pertussis, PLoS ONE, 6: e17797, 2011
3) Kyota Kimura, Masato Iwatsuki, Takeshi Nagai, Atsuko Matsumoto, Yoko Takahashi, Kazuro Shiomi, Satoshi Omura and Akio Abe:
A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection withCitrobacter rodentium, The Journal of Antibiotics, 64: 197–203, 2011
4) Asaomi Kuwae, Hong Sjölinder, Jens Eriksson, Sara Eriksson, Yao Chen, Ann-Beth Jonsson:
NafA negatively controls Neisseria meningitidis pixilation, PLoS ONE, 6(7): e21749, 2011 more info.
doi:10.1371/journal.pone.0021749
2010
1) Eiji Komatsu, Fuminori Yamaguchi, Akio Abe, Alison A. Weiss, and Mineo Watanabe:
Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model, Clin Vaccine Immunol., 17: 807-12, 2010
2) Jun Kurushima, Takeshi Nagai, Kanna Nagamatsu, Akio Abe: EspJ effector in enterohemorrhagic E. coli translocates into host mitochondria via an atypical mitochondrial targeting signal, Microbiology and Immunology, 54: 371-379, 2010
2009
1) Kanna Nagamatsu, Asaomi Kuwae, Tadashi Konaka, Shigenori Nagai, Sei Yoshida, Masahiro Eguchi, Mineo Watanabe, Hitomi Mimuro, Shigeo Koyasu, and Akio Abe:
Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN, J. Exp. Med., 206: 3073-3088, 2009
2) 阿部章夫:
感染現象 その理解の深化から疾患制御への展望: 細菌の病原因子分泌機構の新展開, 蛋白質 核酸 酵素, 54 (8): 969-974, 2009
3) 阿部章夫:
特集 感染症の現代的課題: 細菌のエフェクター輸送システムはどれだけわかっているのか，生体の科学，60 (2) 別冊: 110-116, 2009
4) 阿部章夫:
病原細菌の分泌装置: その機能と病原性発揮のメカニズム，感染症学雑誌，83 (2) 別冊: 94-100, 2009
2008
1) Masato Iwatsuki, Ryuji Uchida, Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Yong-Pil Kim, Tomoyasu Hirose, Toshiaki Sunazuka, Akio Abe, Hiroshi Tomoda, and Satoshi Omura:
Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509 (II. Physico-chemical Properties and Structure Elucidation), J. Antiriot., 61: 230–236, 2008
2) Masato Iwatsuki, Ryuji Uchida, Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Atsuko Matsumoto, Yoko Takahashi, Akio Abe, Hiroshi Tomoda, Satoshi Omura:
Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509 (I. Taxonomy, Fermentation, Isolation and Biological Properties) J. Antiriot., 61(4): 222–229, 2008
3) Akio Abe, Kanna Nagamatsu, and Mineo Watanabe:
The Bordetella type III secretion system: its application to vaccine development, Microbiology and Immunology, 52: 128-133, 2008
2007
1) Hitomi Mimuro, Toshihiko Suzuki, Shigenori Nagai, Gabriele Rieder, Masato Suzuki, Takeshi Nagai,Yukihiro Fujita, Kanna Nagamatsu, Nozomi Ishijima,Shigeo Koyasu, Rainer Haas, and Chihiro Sasakawa:
Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach, Cell Host and Microbe, 2: 250-263, 2007
2) Tsuyoshi Miki, Nobuhiko Okada, Yeongsuk Kim, Akio Abe and Hirofumi Danbara:
DsbA directs efficient expression of outer membrane secretin EscC of the enteropathogenic Escherichia coli type III secretion apparatus, Microbial pathogenesis 44: 151-158, 2007
3) Kachiko Sekiya, Takumi Akagi, Kiyoko Tatsuta, Eriko Sakakura, Tsutomu Hashikawa, Akio Abe, Hideaki Nagamune:
Ultrastructural analysis of the membrane insertion of domain 3 of streptolysin O, Microbes and Infection 9: 1341-1350, 2007
4) Miyuki Hanajima-Ozawa, Takeshi Matsuzawa, Aya Fukui, Shigeki Kamitani, Hiroe Ohnishi, Akio Abe, Yasuhiko Horiguchi, and Masami Miyake:
Enteropathogenic Escherichia coli, Shigella flexneri, and Listeria monocytogenes recruit a junctional protein, zonula occludens-1, to actin tails and pedestals, Infection and Immunity, 75: 565-573, 2007
5) 桑江朝臣:
ボルデテラ属細菌のタイプIII分泌機構より分泌される蛋白質の機能解析 (平成19年黒屋奨学賞受賞論文), 日本細菌学雑誌, 62(2): 241-246, 2007
2006
1) Sei Yoshida, Yutaka Handa, Toshihiko Suzuki, Michinaga Ogawa, Masato Suzuki, Asuka Tamai, Akio Abe, Eisaku Katayama, Chihiro Sasakawa: Microtubule-severing activity of Shigella is pivotal for intercellular spreading, Science, 314: 985-989, 2006
2) Asaomi Kuwae, Takeshi Matsuzawa, Naoto Ishikawa, Hiroyuki Abe, Takashi Nonaka, Hiroyuki, Fukuda, Shinobu Imajoh-Ohmi, and Akio Abe: BopC is a novel type III effector secreted by Bordetella bronchiseptica and has a critical role in type III-dependent necrotic cell death, J. Biol. Chem., 281: 6589-6600, 2006
3) Tomoaki Ogino, Ryuta Ohno, Kachiko Sekiya, Asaomi Kuwae, Takeshi Matsuzawa, Takashi Nonaka, Hiroyuki Fukuda, Shinobu Imajoh-Ohmi, and Akio Abe: Assembly of the type III secretion apparatus of enteropathogenic Escherichia coli, J. Bacteriology, 188: 2801-2811, 2006
4) 阿部章夫, 桑江朝臣:
細菌の病原因子注入装置: TTSS, 感染・炎症・免疫 36: 34-41, 2006
2005
1) Takeshi Matsuzawa, Asaomi Kuwae, and Akio Abe:
Enteropathogenic Escherichia coli type III effectors EspG and EspG2 alter epithelial paracellular permeability, Infect. Immun., 73: 6283-6289, 2005
2) Akio Abe, Takeshi Matsuzawa, and Asaomi Kuwae:
Type-III effectors: Sophisticated bacterial virulence factors (Les effecteurs de type III : facteurs de virulence bactérienne sophistiqués), Comptes Rendus Biologies 328: 413-428, 2005
3) 桑江朝臣, 阿部章夫:
病原細菌のリーサルウェポン “III型分泌装置” (特集 病原細菌と外界を結ぶチャネル - 薬剤排出ポンプと病原因子分泌装置, 堀口安彦・阿部章夫 編), 蛋白質 核酸 酵素, 50: 20-28, 2005
4) 阿部章夫, 桑江朝臣:
腸管病原性大腸菌の感染機構 (特集 解明が進むウイルス・細菌感染と免疫応答 - 分子メカニズムから新たな治療戦略まで -), 実験医学, 23 : 2618-2624, 2005
5) 阿部章夫, 桑江朝臣:
グラム陰性菌の分泌装置, Helicobacter Research, 9: 2-9, 2005
6) 桑江朝臣, 阿部章夫: 細菌のIII型分泌装置とその機能 (特集 新しい感染症成立のメカニズム), 化学療法の領域, 21: 27-33, 20057) Takeshi Nagai, Akio Abe, and Chihiro Sasakawa:
Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis, J. Biol. Chem. 280: 2998-3011, 2005
8) Masami Miyake, Miyuki Hanajima, Takeshi Matsuzawa, Chiho Kobayashi, Masayoshi Minami, Akio Abe, and Yasuhiko Horiguchi: Binding of intimin with Tir on the bacterial surface is prerequisite for the barrier disruption induced by enteropathogenic Escherichia coli, BBRC 337: 922-927, 2005
9) Hideo Kobayashi, Asaomi Kuwae, Hideaki Maseda, Akira Nakamura, and Takayuki Hoshino: Isolation of a low-molecular-weight, multicopy plasmid, pNHK101, from Thermus sp. TK10 and its use as an expression vector for T. thermophilus HB27, Plasmid, 54: 70-79, 2005
10) 桑江朝臣:
ボルデテラ属細菌のタイプIII分泌装置より分泌されるBopCの機能解析 (第87回日本細菌学会関東支部総会 支部総会賞受賞論文),
日本細菌学会関東支部ニュース, 45: 4-7, 2005
2004
1) Takeshi Matsuzawa, Asaomi Kuwae, Sei Yoshida, Chihiro Sasakawa, and Akio Abe: Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1, EMBO J., 23: 3570-3582, 2004
2) Hisashi Nogawa, Asaomi Kuwae, Takeshi Matsuzawa, and Akio Abe: The type III secreted protein, BopD, in Bordetella bronchiseptica is complexed with BopB for pore formation on the host plasma membrane, J. Bacteriology, 186: 3806-3813, 2004
3) US Patent 6586200 B2 Satoshi Omura and Akio Abe : Method for detecting substances inhibiting the bacterial type III secretion mechanizm and function of secretory proteins thereof, 2004
4) 阿部章夫: 蛋白質輸送 病原細菌エフェクターの宿主細胞への旅立ち, 蛋白質 核酸 酵素, 49: 967-970 (2004)
5) Takeshi Matsuzawa, Aya Fukui, Takashige Kashimoto, Kaori Nagao, Kiyomasa Oka, Masami Miyake, and Yasuhiko Horiguchi:
Bordetella dermonecrotic toxin undergoes proteolytic processing to be translocated from a dynamin-related endosome into the cytoplasm in an acidification-independent manner, J. Biol. Chem., 279: 2866-2872, 2004
2003
1) Asaomi Kuwae, Minako Ohishi, Mineo Watanabe, Masaaki Nagai, and Akio Abe: BopB is a type III secreted protein in Bordetella bronchisepticaand is required for cytotoxicity against cultured mammalian cells, Cellular Microbiology, 5: 973-983, 2003
2) 阿部章夫: エフェクターの分泌と宿主細胞への移行, Helicobacter Research, 7: 12-17, 2003
3) 関矢加智子, 阿部章夫: 病原大腸菌の病原因子の分泌機構, 電子顕微鏡, 38: 52-55, 2003
4) 阿部章夫: 腸管出血性大腸菌, 分子予防環境医学(単行本), 分子予防環境医学研究会編: 307-322, 2003
5) Takashi Nonaka, Taku Kuwabara, Hitomi Mimuro, Asaomi Kuwae, and Shinobu Imajoh-Ohmi: Shigella-induced necrosis and apoptosis of U937 cells and J774 macrophages, Microbiology, 149: 2513-2527, 2003
6) 桑江朝臣:
Bordetella属細菌のタイプIII分泌機構より分泌される新規病原因子の機能解析, 獣医畜産新報, 56: 599-600, 2003
1995-2002
1) Kachiko Sekiya, Minako Ohishi, Tomoaki Ogino, Koichi Tamano, Chihiro Sasakawa, and Akio Abe:
Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath- like structure. Proc Natl Acad Sci USA, 98: 11638-11643, 2001
2) Akio Abe, Ursula Heczko, Richard G. Hegele, and B. Brett Finlay: Two enteropathogenic Escherichia coli type III Ssecreted proteins, EspA and EspB, are virulence factors. J. Exp. Med., 188: 1907-1916, 1998
3) Akio Abe, Myriom de Grado, Richard A. Pfuetzner, Claudia Sanchez-Sanmartin, Rebekah De Vinney, Jose Luis Puente, Natalie C. J. Strynadka, and B. Brett Finlay: Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion. Mol. Microbiol., 33: 1162-1175, 1999
4) Akio Abe, Brendan Kenny, Markus Stein, and B. Brett Finlay: Characterization of two virulence proteins secreted by rabbit enteropathogenic Escherichia coli, EspA and EspB, whose maximal expression is sensitive to host body temperature, Infect. Immun., 65: 3547-3555, 1997
5) B. Brett Finlay and Akio Abe:
Enteropathogenic E. coli interactions with host cells, Jpn. J. Med. Sci., Biol. 51: S91-100, 1998
6) 阿部章夫:
特集 感染するメカニズム, 防御するメカニズム: 腸管病原性大腸菌のタイプ III分泌機構を介した腸管への付着のメカニズム, 笹川千尋（編） 細胞工学 21: 157-161, 2002
7) 増田美奈子, 阿部章夫: 病原因子の宿主細胞へのデリバリーシステムとその機能, 蛋白質 核酸 酵素, 46: 512-518, 2001
8) 阿部章夫: 病原細菌のタイプ III分泌機構を標的とした阻害剤の探索系の確立, The Japanese Journal of Antibiotics, 55: 331-336, 2002
9) 阿部章夫, 桑江朝臣 (櫻井純, 本田武司, 小熊恵司 編): 細菌毒素ハンドブック: エフェクター, サイエンスフォーラム, 2002
10) Asaomi Kuwae, Sei Yoshida, Koichi Tamano, Hitomi Mimuro, Toshihiko Suzuki, and Chihiro Sasakawa:
Shigella invasion of macrophage requires the insertion of IpaC into the host plasma membrane. Functional analysis of IpaC, J. Biol. Chem., 276: 32230-32239, 2001 more info.
11) Takeshi Matsuzawa, Takeshige Kashimoto, Jun Katahira, and Yasuhiko Horiguchi:
Identification of a receptor-binding domain of Bordetella dermonecrotic toxin. Infect. Immun., 70: 3427-3432, 2002
12) Sei Yoshida, Eisaku Katayama, Asaomi Kuwae, Hitomi Mimuro, Toshihiko Suzuki, and Chihiro Sasakawa:
Shigella deliver an effector protein to trigger host microtubule destabilization, which promotes Rac1 activity and efficient bacterial internalization. EMBO J., 21: 2923-2935, 2002
13) Minako Masuda, Masayoshi Minami, Hiroaki Shime, Takeshi Matsuzawa, and Yasuhiko Horiguchi:
In vivo modifications of small GTPase Rac and Cdc42 by Bordetella dermonecrotic toxin, Infect. Immun., 70: 998-1001, 2002
14) Takahito Toyotome, Toshihiko Suzuki, Asaomi Kuwae, Tadashi Nonaka, Hiroyuki Fukuda, Shinobu Imajoh-Ohmi, Toshihiko Toyofuku, Masatsugu Hori, and Chihiro Sasakawa:
Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus, J. Biol. Chem., 276: 32071-32079, 2001
15) Peter Feng, Manashi Dey, Akio Abe, and Tae Takeda: Isogenic strain of Escherichia coli O157:H7 that has lost both Shiga toxin 1 and 2 genes, Clin. Diagn. Lab. Immune., 8: 711-717, 2001
16) Koichi Tamano, Shin-Ichi Aizawa, Eisaku Katayama, Takashi Nonaka, Shinobu Imajoh-Ohmi, Asaomi Kuwae, Shinya Nagai, and Chihiro Sasakawa:
Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors, EMBO J., 19: 3876-3887, 2000
17) Carol O. Tacket, Marcelo B. Sztein, Genevieve Losonsky, Akio Abe, B. Brett Finlay, Barry P. McNamara, George T. Fantry, Stephen P. James, James P. Nataro, Myron M. Levine, and Michael S. Donnenberg:
Role of EspB in experimental human enteropathogenic Escherichia coli Infection, Infect. Immun., 68: 3689-3695, 2000
18) Minako Masuda, Lazaro Betancourt, Takeshi Matsuzawa, Takashige Kashimoto, Toshifumi Takao, Yasutsugu Shimonishi, and Yasuhiko Horiguchi:
Activation of Rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin, EMBO J. 19: 521-530, 2000
19) Ursula Heczko, Akio Abe, and B. Brett Finlay: Segmented filamentous bacteria prevent colonization of enteropathogenic Escherichia coli 0103 in Rabbits, J. Infect. Dis. 181: 1027-1033, 2000
20) Ursula Heczko, Akio Abe, and B. Brett Finlay:
In vivo interactions of rabbit enteropathogenic Escherichia coli O103 with its host: An electron microscopic and histopathologic study, Microbes. Infect., 2: 5-16, 2000
21) Akio Abe and Hideki Nagano:
Functional analysis of the type III secretion system in enteropathogenic Escherichia coli O157:H45, Microbiol. Immune., 44: 857-861, 2000
22) Takashi Nonaka, Asaomi Kuwae, Chihiro Sasakawa, and Shinobu Imajoh-Ohmi: Shigella flexneri YSH6000 induces two types of cell death, apoptosis and oncosis, in the differentiated human monoblastic cell line U937, FEMS Microbiol. Lets., 174: 89-95, 1999
23) Takashige Kashimoto, Jun Katahira, Willian R. Cornejo, Minako Masuda, Atsushi Fukuoh, Takeshi Matsuzawa, Takahiro Ohnishi, and Yasuhiko Horiguchi:
Identification of functional domains of Bordetella dermonecrotizing toxin, Infect. Immun., 67: 3727-3732, 1999
24) Rebekah DeVinney, Markus Stein, Dieter Reinscheid, Akio Abe, Sharon Ruschkowski, and B. Brett Finlay:
Enterohemorrhagic Escherichia coli O157:H7 produces Tir, which is translocated to the host cell membrane but Is not tyrosine phosphorylated, Infect. Immun., 67: 2389-2398, 1999
25) Rebekah DeVinney, Akio Abe, and B. Brett Finlay:
Enteropathogenic Escherichia coli: a pathogen that inserts its own receptor into host cells, Cell. Mol. Life. Sci., 55: 961-976, 1999
26) Myriam de Grado, Akio Abe, Annick Gauthier, Olivia Steele-Mortimer, Rebekah DeVinney, and B. Brett Finlay: Identification of the intimin binding domain of Tir of enteropathogenic Escherichia coli. Cellular Microbiology, 1: 7-17, 1999
27) Toko Mitsui-Yamaguchi, Akio Abe, Hirofumi Danbara, and Kazuyoshi Kawahara:
Induction of TNF-α mRNA in murine macrophages by virulent and anvirulent strains of Salmonella choleraesuis serovar Typhimurium and serovar Choleraesuis, Microb. Pathogen 22: 59-66, 1997
28) Brendan Kenny, Akio Abe, Markus Stein, and B.Brett Finlay:
Enteropathogenic Escherichia coli protein secretion is induced in response to conditions similar to those in the gastrointestinal tract, Infect. Immun. 65: 2606-2612, 1997
29) Jérôme M. B. Durand, Glenn R. Björk, Asaomi Kuwae, Masanosuke Yoshikawa, and Chihiro Sasakawa:
The modified nucleoside 2-methylthio-N6-isopentenyladenosine in tRNA of Shigella flexneri is required for expression of virulence genes, J. Bacteriology, 179: 5777-5782, 1997
30) Tohru Miyoshi-Akiyama, Akio Abe, Hidehito Kato, Kazuyoshi Kawahara, Hisashi Narimatsu, and Takehiko Uchiyama:
DNA sequencing of the gene encoding a bacterial super antigen, Yersinia pseudotuberculosis-derived mitogen (YPM), and characterization of the gene product, cloned YPM, J. Immune., 154: 5228-5234, 1995
31) Akio Abe and Kazuyoshi Kalahari: Transcriptional regulation and promoter sequence of the spvR gene of virulence plasmid pKDSC50 in Salmonella choleraesuis serovar Choleraesuis, FEMS Microbiol. Lett. 129: 225-230, 1995