The scientific cosmology is based on the description of gravitation by the General Theory of Relativity, more specifically in the solutions of the Friedmannn equations for a model of isotropic and homogeneous universe on a large scale (metric Friedmann-Robertson-Walker FRW) and continued expansion according to Hubble's Law. According to this description the dynamics of the universe would be determined by the amount of matter existing in it, which in turn determines the large-scale geometry of space-time. Recent observations of relic radiation in the Cosmic Microwave Background (CMB) have confirmed in essence the predictions of the Big Bang model and seem to corroborate the predictions of the FRW universe models with zero curvature (k = 0). More refined measures of CMB anisotropies ( Hinshaw 2009, Komatsu et al 2010) with the measurements of the supernovae (SNe Ia) at high redshift (Riess 1998, Perlmutter 1999) suggest the existence of a cosmic acceleration in accordance with the predictions of the model universe with constant cosmological (Λ≠0). This large-scale cosmic acceleration, also called dark energy, is today one of the most important enigmas of modern cosmology (see Peebles & Rastra 2003, Peebles 2020, Carroll & Tunner 1992; and references therein) . Even more disturbing is the apparent contradiction between the models of the universe with zero curvature (k = 0) in the FRW formalism and the total density parameter (Ω), according to which should be exactly equal to unity, but the observed density of matter is an order of magnitude lower than expected to play the null curvature (Overduin & Wesson 2008). Assuming that the dynamics of the universe is prescribed only by the force of gravity (as the only fundamental force in the astronomical scales) we encounter serious difficulties in describing the behavior of the Universe:-i-Can not explain the rotation curves of galaxies, which show its incompatibility with the virialized masses of the galaxies (Sofue 1999, Sanders 2002, Freese 2000).-ii-Into of the rich clusters of galaxies, the mass observed in the form of stars and the gas mass inferred from the X-ray diffuse emission is significantly less than that required to maintain these systems gravitationally stable (Overduin & Wesson 2008, Shirata et al 2005).-iii-In cosmological scales, the observed baryonic matter density is much lower than predicted by the FRW models with cosmological constant and curvature zero (Peebles & Rastra 2003, Peebles 2007, Carroll & Tunner 1992, Overduin & Wesson 2008) . The problem of missing mass appears to affect the dynamics at all length scale beyond the Solar System (Freese 2000). One solution has been to propose the requirement of missing material of unknown origin (non baryonic Dark Matter) with equally unknown properties and only interacts gravitationally with ordinary matter. However, after more than a two decades of strenuous efforts: theoretical, astronomical observations and laboratory experiments, only their existence has been suggested conjectural or paradigmatically. In recent years there have been several alternatives to dark matter paradigm to explain the rotation curves of galaxies, or as alternatives to the TGR and the Big Bang cosmology. Among the first calls include MOND theories, which reproduced successfully the rotation curves of galaxies. But the formalism of the MOND theories (i) can not resolved the lack of dark matter at scales of clusters of galaxies (ii) neither the missing masses in the cosmological scale and (iii) is based on the modification of the Gravitation Universal Law to scales larger than the solar system, where the dependence of the force of gravity does not necessarily verify the law of the inverse of the square. In the same vein are the Theories of Moffat (Moffat 2006), who postulates a modification of the Universal Gravitation constant, although it is a very promising alternative to the paradigm of Dark Matter, faces problems that a variation of 25% or more in the constant acceleration of gravity would imply an abundance of helium incompatible with the observations (Reeves 1994, Melnikov 2009). Among the proposed changes to the TRG the most promising are those that postulate the existence of an additional scalar field metric tensor (Branks-Dicke theory) (Fujii & Maeda 2004) and within this so-called quintessence scenarios (Martin 2008) to postulate a new fundamental interaction, additional to gravity and electroweak interactions (electromagnetic and weak nuclear force) and strong nuclear force.While it is true that the validity of inverse square law of Newton's gravity is verified with precisions greater than 10-8 for Eötvös-like experiments (Adelberger et al. 2003), there is no empirical evidence of their validity beyond the Solar System (Silverman 1987, Gundlach 2005); it is assumed true for estimating the mass of binary stars. For a review of the many theoretical speculations about deviations from the r-2 law; see Adelberger and references therein (Adelberger et al. 2003). From the very beginning of cosmology and pre-relativistic ideas raised in the modification of gravity beyond the solar system (Goldman 1987 , Bondi 1951), but the experiments in laboratories on Earth and in the inner solar system, constitute a strong constraint for any alleged field the anti-gravity with range much greater than 1 AU (Goldman 1987). The universal character of Newton's Gravitation law was given by Kant in 1755, considering the deductive character of the planetary motion and the Leverrier’s prediction for the discovery of Neptune. Recall that galaxies acquire identity after the great debate Shapley-Curtis in 1920.Also Laplace and Seeliger theorized in the eighteenth century, modifications to the Law of gravitation (Bondi 1951; Seeliger 1895, Laves 1898). In relation to the hypothesis of non baryonic Dark Matter the history of science has shown many examples the paradigmatic assumptions to explain the behavior of the nature, which later were nonexistent and replaced by alternatives measurable. Such as the cycles and epicycles of Ptolemy, the ether before the advent of the Special Theory of Relativity, the “caloric” (as elementary substance) before the work of Joule and Carnot. In all cases, a review of the assumptions in the phenomenological description of the processes, led to a breakthrough in our understanding of natural reality.