Publications

2024

• Heberle, F.A. and Waxham, M.N. (2024). Phase separation in model lipid membranes investigated with cryogenic electron microscopy. Methods Enzymol. 2024:700:189-216.doi: 10.1016/bs.mie.2024.03.003. Epub 2024 Mar 21.

• Srivastava, Y., Donta, M., Mireles, L.L., Paulucci-Holthauzen, A., Shi, L., Bedford, M.T., Waxham, M.N., McCrea, P.D. (2024). Exploring the PDZ, DUF, and LIM domains of Pdlim5 in dendrite branching. Int J Mol Sci. 2024 Jul 30;25(15):8326. doi:10.3390/ijms25158326. PMID: 39125895.

• Sharma, K.D., Doktorova, M., Waxham, M.N. and Heberle, F.A. (2024) Cryo-EM images of phase separated lipid bilayer vesicles analyzed with a machine learning approach. Biophys. J. Apr 30:S0006-3495(24)00291-1. doi: 10.1016/j.bpj.2024.04.029.

• Purnell C, Heebner J, Swulius MT, Hylton R, Kabonick S, Grillo M, Grigoryev S, Heberle F, Waxham MN, Swulius MT. Rapid Synthesis of Cryo-ET Data for Training Deep Learning Models. bioRxiv [Preprint]. 2023 Apr 28:2023.04.28.538636. doi: 10.1101/2023.04.28.538636. PMID: 37162972; PMCID: PMC10168359.

• Srivastava Y, Donta M, Mireles LL, Paulucci-Holthauzen A, Waxham MN, McCrea PD. Role of a Pdlim5:PalmD complex in directing dendrite morphology. Front Cell Neurosci. 2024 Feb 13;18:1315941. doi: 10.3389/fncel.2024.1315941. PMID: 38414752; PMCID: PMC10896979.

2023

• Underwood EL, Redell JB, Hood KN, Maynard ME, Hylin M, Waxham MN, Zhao J, Moore AN, Dash PK. Enhanced presynaptic mitochondrial energy production is required for memory formation. Sci Rep. 2023 Sep 2;13(1):14431. doi: 10.1038/s41598-023-40877-0. PMID: 37660191; PMCID: PMC10475119.

• Ward, A.E., Sokovikova, D., Waxham, M.N., Heberle, F.A., Levental, I., Levental K.R., Kiessling, V., White, J.M., Tamm, L.K. (2023) Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane. ACS Infectious disease. 9(4):773-784. doi: 10.1021/acsinfecdis.2c00478. Epub 2023 Mar 22.PMID: 36946615.

• Nde, J., Zhang, P., Waxham, M.N., and Cheung M.S. (2023) Experiments and simulation reveal residue details for how target binding tunes calmodulin’s calcium-binding properties. J. Phys. Chem B. 127(13):2900-2908. doi: 10.1021/acs.jpcb.2c08734. Epub 2023 Mar 28.PMID: 36977372. 

• Sharma K.D., Heberle F.A., Waxham M.N. (2023) Visualizing lipid membrane structure with cryo-EM: past, present, and future. Emerg Top Life Sci. 10.1042/ETLS20220090. Epub ahead of print. PMID: 36606590.

• Donta, M., Srivastava, Y., Di Mauro, C. M., Paulucci-Holthauzen, A., Waxham, M.N., and McCrea, P.  (2023) p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development. 17:1151249. doi: 10.3389/fncel.2023.1151249. eCollection 2023.PMID: 37082208.

2022

• Heberle, F.A., Welsch, D., Scott, H.L., and Waxham, M.N. (2022) Optimization of cryo-electron microscopy for quantitative analysis of lipid bilayers. Biophys Rep (N Y). 10;3(1):100090. doi: 10.1016/j.bpr.2022.100090. PMID: 36593976; PMCID:

2021

• Symons, J., Cho, K.-J., Chang, J., Du, G., Waxham, M.N., Hancock, J.F., Levental, I. and Levental, K.R. (2020). Lipidomic atlas of mammalian cell membranes reveals hierarchical variation induced by culture conditions, subcellular membranes, and cell lineages.  Soft Matter. DOI: 10.1039/D0SM00404A.

2020

• Baumert, R., Ji, H., Paulucci-Holthauzen, A., Wolfe, A., Sagum, C., Arikkath, J., Chen, X., Bedford, M.T., Waxham, M.N., and McCrea, P.D. (in press) Novel phosphor-switch function of delta-catenin in dendrite development.  J. Cell Biol. 2;219(11):e201909166. doi: 10.1083/jcb.201909166.PMID: 33007084

• Gu, X., Schafer, N.P., Wang, Q., Song, S.S., Chen, M., Waxham, M.N., and Wolynes, P. (2020). Exploring the F-actin/CPEB3 interaction and its possible role in the molecular mechanism of long-term memory.  Proc. Natl. Acad. Sci. USA.   117(36):22128-22134. doi: 10.1073/pnas.2012964117. Epub 2020 Aug 26.PMID: 32848053 

• Gireaud-Goss, M., Reyes, S., Tewari, R., Patrizz, A., Howe, M.D., Kofler, J., Waxham, M.N., McCullough, L. D., and Bean, A.J. (2020) The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid b42 generation and secretion. Mo. Cell. Neurosci. 108:103542 doi: 10.1016/j.mcn.2020.103542. Epub 2020 Aug 22.PMID: 32841720 

• Heberle, FA., Doktrova, M., Scott, H.L., Skinkle, A.D., Waxham, M.N., and Levental, I. (2020). Direct label-free imaging of nanodomains in biomimetic and biological membranes by cryogenic electron microscopy. Proc. Natl. Acad. Sci. USA 117(33):19943-19952. doi: 10.1073/pnas.2002200117. Epub 2020 Aug 5.PMID: 32759206 

• Maynard, M.E.,  Redell, J., Kobori, N., Underwood, E., Fischer, T.D., Hood, K.N., LaRoche, V.,  M N Waxham, M.N., Moore, A.N. and Dash, P.D. (2020). Loss of PTEN-induced kinase1 (Pink1) reduces hippocampal tyrosine hydroxylase and impairs learning and memory. Exp. Neurol. Jan;323:113081. doi: 10.1016/j.expneurol.2019.113081.

• Ezerski, J.C., Zhang, P., Jennings, N.C., Waxham, M.N. and Cheung, M.S. (2020).  Molecular Dynamics Ensemble Refinement of Intrinsically Disordered Peptides According to Deconvoluted Spectra from Circular Dichroism. Biophys J. 2020 Feb 25. pii: S0006-3495(20)30164-8. doi: 10.1016/j.bpj.2020.02.015.

• Liman, J., Bueno, C., Eliaz, Y., Schafer, N.P., Waxham, M.N., Wolynes, P.G., Levine, H., and Cheung, M.S. (2020) The role of the Arp2/3 complex in shaping the dynamics and structure of branched actomyosin networks. Proc. Natl. Acad. Sci. USA.  117(20):10825-10831. doi: 10.1073/pnas.1922494117. Epub 2020 Apr 30.PMID: 32354995 

2019

• Wang,Q., Chen, M., Schafer, N.P., Bueno, C. Song, S.S., Hudmon, A. Wolynes, P.G., Waxham, M.N. and Cheung, M.S. (2019) Calcium/calmodulin-dependent kinase II – Actin assemblies and their dynamic regulation by calmodulin in dendritic spines. Proc. Natl. Acad. Sci. USA.

• Scott, H., Skinkle, E., Kelley, E., Waxham, M.N., Levental, I. and Heberle, F.A., (2019) On the mechanism of bilayer separation by extrusion; or, why your large unilamellar vesicles are not really unilamellar.  Biophysical J.

2018

• Gireud-Goss, M., Reyes, S., Wilson, M., Farley, M., Memarzadeh, K., Srinivasan, S., Sirisaengtaksin, N., Yamashita, S., Tsunoda, S., Lang, F.F., Waxham, M.N., Bean, A.J. (2018) Distinct mechanisms enable inward or outward budding from late endosomes/multivesicular bodies. Exp. Cell Res. 372, 1-15. https://www.sciencedirect.com/science/article/pii/S001448271830778X?via%3Dihub

• Fischer, T.D., Dash, P.K., Liu, J. and Waxham, M.N. (2018) Morphology of Mitochondria in Spatially Restricted Axons Revealed by Cryo-Electron Tomography.  PloS Biology. e2006169. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006169

• Park, D., Hu, B., Lara-Tejero, M., Waxham, M.N., Galan, J. and Liu, J. (2018) Visualization of the type III secretion mediated Salmonella-host cell interface using cryo-electron tomography. eLife. e39514. https://elifesciences.org/articles/39514

2017

• Sarkar-Banerjee, S., Sayyed-Ahmad, A., Prakash, P., Cho, K.J., Waxham, M.N., Hancock, J.F., Gorfe, A.A. (2017) Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes. J. Am. Chem. Soc. 139, 13466-13475. https://pubs.acs.org/doi/10.1021/jacs.7b06292

• Hoffman, L., Li, L., Alexov, E., Sanabria, H., and Waxham, M.N. (2017) Cytoskeletal-like filaments of CaMKII are formed in a regulated and Zn2+-dependent manner. Biochemistry 56, 2149-2160. https://pubs.acs.org/doi/10.1021/acs.biochem.7b00028

2016

• Lin, X., Lorent, J., Skinkle, A., Levental, K., Waxham, M.N., Gorfe, A., Levental, I. (2016) Domain stability in biomimetic membranes driven by lipid polyunsaturation. J.Phys.Chem. 120, 11930-11941. https://pubs.acs.org/doi/10.1021/acs.jpcb.6b06815

• Tulodziecka K, Diaz-Rohrer BB, Farley MM, Chan RB, Di Paolo G, Levental KR, Waxham MN, and Levental I. (2016). Remodeling of the postsynaptic plasma membrane during neural development. Mol Biol. Cell. 27, 3480-3489. https://www.molbiolcell.org/doi/10.1091/mbc.e16-06-0420

• Fischer, TD, Hylin, MJ, Zhao, J, Moore, AN, Waxham, MN and Dash, PK (2016). Altered mitochondrial dynamics and TBI pathophysiology. Front. Syst. Neurosci. http://dx.doi.org/10.3389/fnsys.2016.00029.

2015

• Farley MM, Swulius MT, and Waxham M.N. (2015) Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities. 304:286-301.

• Tripathi S, Wang Q, Zhang P, Hoffman L, Waxham MN, Cheung MS. (2015) Conformational frustration in calmodulin-target recognition. J. Mol. Recognit. 28:74-86.

2014

• Jin, S.X., Bartolome, C., Arai, J.A., Hoffman, L., Uzturk, B.G., Kumar-Singh, R., Waxham, M.N. and Feig, L.A. (2014) Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF)1 and Ras-GRF2. J. Biol. Chem. 289: 16551-16564.

• Hoffman, L., Chandrasekar, A. Wang, X., Putkey, JA, and Waxham, M.N. (2014) Neurogranin alters the structure and calcium binding properties of calmodulin. J. Biol. Chem. 289: 14644-14655.

• Sizovs, A., Song, X., Waxham, M.N., Jia, Y., Feng, F., Chen, J., Wicker, A.C., Xu, J., Yu, Y., Wang. J. (2014) Precisely Tunable Engineering of Sub-30 nm Monodisperse Oligonucleotide Nanoparticles. J Am Chem Soc. 136: 234-240.

2013

• Hoffman, L., Farley, MM, and Waxham, M.N. (2013) Calcium-calmodulin-dependent protein kinase II isoforms differentially impact the dynamics and structure of the actin cytoskeleton. Biochemistry 53: 1198-1207.

• Wang, Q., Zhang, P., Hoffman, L., Tripathi, S., Homouz D, Liu, Y., Waxham, M.N., and Cheung, M.S. (2013) Protein recognition and selection through conformational and mutually induced fit. Proc Natl Acad Sci U S A. 110(51): 20545-20550.

2012

• Swulius, M.T., Farley, M.M., Bryant, M.A., and Waxham, M.N. (2012) Electron cryotomography of postsynaptic densities during development reveals a mechanism of assembly. Neuroscience. 212: 19-29.​

2011

• Wang, Q., Liang, K. -C., Czader, A., Waxham, M.N. and Cheung, M.S. (2011) The effect of macromolecular crowding, ionic strength and calcium binding on calmodulin dynamics. PloS Comput. Biol.  7: 1-16. e1002114

• Byrne, M.J., Waxham, M.N., and Kubota, Y. (2011) The impacts of geometry and binding on CaMKII diffusion and retention in dendritic spines. J. Comp. Neurosci. 31:1-12

2010

• Kubota, Y. and Waxham, M.N. (2010) Lobe Specific Ca2+-Calmodulin Nano-Domain in Neuronal Spines: A Single Molecule Level Analysis.  PLoS Comp. Biol.

• Neumuller, K.G., Elsayad, K., Reisecker, J.M., Waxham, M.N., and Heinze, K.G. (2010) Photounbinding of Calmodulin from a family of CaM Binding Peptides. PLoS One.

• Kim, S.A., Sanabria, H., Digman, M.A., Gratton, E., Schwille, P., Zipfel, W.R., and Waxham, M.N. (2010) Quantifying translational mobility in neurons: Comparison between current optical techniques. J. Neurosci. 30:16409-16416.

• Swulius, M., Kubota, Y., Forest, A. and Waxham, M.N.( 2010) Structure and Composition of the Postsynaptic Density during Development. J. Comp. Neuro. 518: 4243-4260.

• Kubota, Y., Byrne, M.J. and Waxham, M.N. (2010).  Cellular Dynamic Simulator: An event driven molecular simulation environment for cellular physiology. Epub ahead of print.  Neuroinformatics.

• Sanabria, H. and Waxham, M.N. (2010) Transient Anomalous Subdiffusion: Effects of Specific and Non-specific Probe Binding with Actin Gels. J. Phys. Chem. B 114: 959-972.​

2000-2009

• Byrne, M.J., Putkey, J.A., Waxham, M.N., and Kubota, Y.  (2009). Dissecting cooperative calmodulin binding to CaM kinase II: A detailed stochastic model. J. Comp. Neurosci. J. Comp. Neurosci. 27: 621-638

• Homouz, D., Sanabria, H, Waxham, M.N., and Cheung, M.S. (2009). Modulation of calmodulin plasticity by the effect of macromolecular crowding. J. Mol. Biol. 391: 933-943.

• Sanabria, H., Swulius, M. T., Kolodziej. S.J., Liu, J. and Waxham, M.N. (2009). bCaMKII regulates actin assembly and structure. J. Biol. Chem. 284: 9770-9780.

• Forest, A., Swulius, M.T., Tse, J.K.Y., Bradshaw, J.M., Gaertner, T. and Waxham, M.N. (2008).  Role of the N- and C-lobes of calmodulin in the activation of Ca2+/calmodulin-dependent protein kinase II.  Biochemistry 47: 10587-10599.

• Goins, A.B., Sanabria, H. and Waxham, M.N. (2008).  Macromolecular crowding and size effects on probe microviscosity.  Biophys. J. 95: 5362-5373.

• Sanabria, H., Digman, M., Gratton, E. and Waxham, M.N. (2008).  Spatial diffusivity and availability of intracellular calmodulin. Biophs. J. 95: 6002-6015.

• Swulius, M.T. and Waxham, M.N. (2008) Ca2+/CaM-dependent protein kinases. Cell and Mol. Life Sci. 65: 2637-2657.

• Kobota, Y. Putkey, J.A., Shouval, H., and Waxham, M.N. (2008) IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin. J. Neurophys. 99: 264-276.

• Park, H.Y., Kim, S.A., Korlach, J., Rhoades, E., Kwok, L.W., Zipfel, W.R., Waxham, M.N., Webb, W.W., and Pollack, L. (2008).  Microfluidic mixer reports rapid conformational changes of calmodulin.  Proc. Natl. Acad. Sci. USA. 105: 542-547.

• Kubota, Y., Putkey, J.A., and Waxham, M.N. (2007) Neurogranin controls the spatiotemporal pattern of postsynaptic Ca2+/CaM signaling. Biophys. J. 93: 3848-3859.

• Putkey, J.A., Waxham, M.N., Gaertner, T.R., Brewer, K.J., Goldsmith, M., Kubota, Y. and Kleerekoper, Q.K. (2008) Acidic/IQ motif regulator of calmodulin. J. Biol. Chem. 283: 1401-1410.

• Sanabria, H., Kubota, Y., and Waxham, M.N. (2007) Multiple diffusion mechanisms due to nanostructuring in crowded environments. Biophys. J. 92: 313-322.

• Zhao, X., Ou, Z., Grotta, J.C., Waxham, N. , and Aronowski, J. (2006) Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity.  Brain Res. 16: 1073-1074: 460-469.

• Pullan, L., Mullapudi, S., Huang, Z., Baldwin , P.R., Chin, C., Sun, W., Tsujimoto, S., Kolodziej, S.J., Stoops, J.K., Lee, J.C., Waxham, M.N. , Bean, A.J. and Penczek, P.A. (2006) The endosome-associated protein Hrs is hexameric and controls cargo sorting as a “master molecule”.  Structure 14: 661-671.

• Iyer, V., Rossow, M.J., and Waxham, M.N. (2006) Peak two-photon molecular brightness of fluorophores is a robust measure of quantum efficiency and photostability. J. Opt. Soc. Am. B. 23: 1420-1433.

• Hudmon, A., Lebel, E., Roy, H., Sik, A., Schulman, H., Waxham, M.N., De Koninck, P. (2005) A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci. 25:6971-83.

• Quintana, A.R., Wang, D., Forbes, J.E., Waxham, M.N. (2005) Kinetics of calmodulin binding to calcineurin. Biochem Biophys Res Commun. 334:674-80.

• Kim S.A., Heinze, K.G., Bacia, K., Waxham, M.N., Schwille, P. (2005) Two-photon cross-correlation analysis of intracellular reactions with variable stoichiometry. Biophys J. 88(6):4319-36.

• Junge, H.J., Rhee, J.-S., Jahn, O., Mansour, M. Varoqueaux, F., Spiess, J., Waxham, M.N. , Rosenmund, C., and Brose, N. (2004) Calmodulin and Munc13 form a Ca 2+ -sensor/effector complex that controls short-term changes in synaptic efficacy. Cell 118: 389-401.

• Gaertner, T.R., Putkey, J.A. and Waxham, M.N. (2004) RC3/Neurogranin and Ca2+/Calmodulin-dependent protein kinase II produce opposing effects on the affinity of calmodulin for calcium. J. Biol. Chem. 279: 39374-39382.

• Gaertner, T.R., Kolodziej, S.J., Wang, D., Kobayashi, R., Koomen, J.M., Stoops, J.K., and Waxham, M.N. (2004) Comparative analysis of the 3-dimensional structures and enzymatic properties of the a, b, g, and d isoforms of Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 279: 12484-12494.

• Kim, S.A, Heinze, K., Waxham, M.N. and Schwille, P. (2004) Intracellular calmodulin availability accessed with two-photon cross-correlation. Proc. Natl Acad. Sci. 101: 105-110.

• Putkey, J.A., Kleerekoper, Q, Gaertner, T.R., and Waxham, M.N. (2003) A new role for IQ motif proteins in regulating calmodulin function. J. Biol. Chem. 278: 49667-49670.

• Kim, S.A., Hudmon, A., Volmer, A., Waxham, M.N. (2001) CaM-kinase II dephosphorylates Thr(286) by a reversal of the autophosphorylation reaction. Biochem Biophys Res Commun. 282:773-80.

• Hudmon, A., Kim , S.A. , Kolb, S.J., Stoops, J.K., and Waxham, M.N. (2001) Light scattering and transmission electron microscopy studies reveal a mechanism for calcium/calmodulin-dependent protein kinase II self-association . J. Neurochem. 76: 1364-1375.

• Flück, M., Booth, F.W., and Waxham, M.N. (2000) Chicken skeletal muscle CaMKII phosphorylates SRF at multiple sites. Biochem. Biophys. Res. Comm. 270: 488-494.

• Kolodziej, S. J., Hudmon, A., Waxham, M.N. and Stoops, J.K. (2000) Three-dimensional reconstructions of CaM-kinase II a and truncated CaM kinase II a reveal an unique organization for its structural core and functional domains. J. Biol. Chem. 275: 14354-14359.

• Aronowski, J., Grotta, J.C., Strong, R., and Waxham, M.N. (2000) Interplay between the gamma isoform of PKC and calcineurin in regulation of vulnerability to focal cerebral ischemia. J. Cereb. Blood Flow and Met. 20: 343-349.

• Flück, M., Waxham, M.N. , Hamilton , M. and Booth, F.W. (2000) Skeletal muscle Ca 2+ -independent kinase activity increases during either hypertrophy or running. J. Appl. Physiol. 88: 352-358.

1990-1999

• Costantin, J.L., Qin, N., Waxham, M.N. , Birnbaumer, L., and Stefani, E. (1999) Complete reversal of run-down in rabbit cardiac Ca 2+ channels by patch-cramming in Xenopus oocytes; partial reversal by protein kinase A. Eur. J. Physiol. 437: 888-894.

• Kolb, S.J., Hudmon, A., Ginsberg, T.R., and Waxham, M.N. (1998) Identification of domains essential for the assembly of calcium/calmodulin-dependent protein kinase II holoenzymes. J. Biol. Chem. 273: 31555-31564.

• Waxham, M.N. , Tsai, A.-L., and Putkey, J.A. (1998) A Mechanism for CaM-trapping by CaM-kinase II defined by a family of CaM-binding peptides. J. Biol. Chem. 273: 17579-17584.

• Cunningham , S.A. , Arrate, M.P., Brock, T.A., and Waxham, M.N. (1997) Interactions of FLT-1 and KDR with phospholipase C gamma. Identification of the phosphotyrosine binding sites. Biochem. Biophys. Res. Comm. Biochem. Biophys. Res. Comm. 240: 635-639.

• Putkey, J.A. and Waxham, M.N. (1996) A peptide model for calmodulin trapping by calcium/calmodulin-dependent protein kinase II. J. Biol. Chem. 271: 29619-29623.

• Moore , A.N., Waxham, M.N. and Dash, P.K. (1996) Neuronal activity increases the phosphorylation of the transcriptional factor cAMP response element-binding protein (CREB) in rat hippocampus and cortex. J. Biol. Chem. 271: 14214-14220.

• Hudmon, A., Aronowski, J., Kolb, S.J., and Waxham, M.N. (1996) Inactivation and self-association of Ca 2+ /calmodulin-dependent protein kinase II during autophosphorylation. J. Biol. Chem. 271: 8800-8808.

• Waxham, M.N. , Grotta, J.C., Silva, A.J., Strong, R., and Aronowski, J. (1996) Ischemia-induced neuronal damage: A role for calcium/calmodulin-dependent protein kinase II. J. Cereb. Blood Flow and Met. 16: 1-6.

• Cunningham , S.A. , Waxham, M.N. , Arrate, P.M., and Brock, T.A. (1995) Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositiol 3-kinase: Mapping of a novel site involved in binding. J Biol. Chem. 270: 20254-20257.

• Kolb, S.J., Hudmon, A. and Waxham, M.N. (1995) Translocation of calcium/calmodulin-dependent protein kinase in a hippocampal slice model. J. Neurochem. 64: 2147-2152

• Westgate , S.A. , Brown, J., Aronowski, J. and Waxham, M.N. (1994) Activity of Ca 2+ /calmodulin-dependent protein kinase II following ischemia: A comparison between CA1 and dentate gyrus in a hippocampal slice model. J. Neurochem. 63: 2217-2224.

• Hanson, S.K., Grotta, J.C., Waxham, M.N. , Aronowski, J., and Ostrow, P. (1994) Calcium/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion in rats. Stroke 25: 466-473.

• Aronowski, J., Waxham, M.N. and Grotta, J.C. (1993) Neuronal protection and preservation of calcium/calmodulin-dependent protein kinase II and protein kinase C activity by dextrorphan treatment in global ischemia. J. Cereb. Blood Flow Metab. 13: 550-557.

• Waxham, M.N. and Aronowski, J. (1993) Protein kinase C phosphorylates Ca 2+ /calmodulin-dependent protein kinase II in vitro. Biochemistry 32: 2923-2930.

• Waxham, M.N. , Malenka, R.C., Kelly, P.T., and Mauk, M.D. (1993) Calcium/calmodulin-dependent protein kinase II regulates hippocampal synaptic transmission. Brain Res. 609: 1-8.

• Aronowski, J.A., Grotta, J.C., and Waxham, M.N. (1992) Ischemia-induced translocation of Ca 2+ /calmodulin-dependent protein kinase II: Potential role in neuronal damage. J. Neurochem. 58: 1743-1753.

• Crow, T., Forrester, J., Williams, M., Waxham, M.N. , and Neary, J.T. (1991). Down regulation of protein kinase C blocks 5-HT-induced enhancement in Hermissenda B photoreceptors. Neurosci. Lett. 121: 107-110.

• Burgin, K., Waxham, M.N. , Rickling, S., Westgate, S. A., Mobley, W., and Kelly P.T. (1990). In situ hybridization histochemistry of Ca 2+ /calmodulin-dependent protein kinase II in the developing rat brain. J. Neurosci. 10: 1788-1798.

• Waxham, M.N. , Aronowski, J., Westgate , S.A. , and Kelly, P.T. (1990). Mutagenesis of Thr-286 in monomeric Ca 2+ /calmodulin-dependent protein kinase II eliminates Ca 2+ /calmodulin-independent activity. Proc. Natl. Acad. Sci. USA. 87: 1272-1277.

1980-1989

• Malenka, R.C., Kauer, J.A., Perkel, D.J., Mauk, M.D., Kelly, P.T., Nicoll, R.A., and Waxham, M.N. (1989). Long-term potentiation: An essential role for postsynaptic calmodulin and protein kinase activity. Nature 340: 554-557.

• Waxham, M.N. , Aronowski, J., and Kelly, P.T. (1989). Functional analysis of Ca ++ /calmodulin-dependent protein kinase II expressed in bacteria. J. Biol. Chem. 264: 7477-7482.

• Waxham, M.N. , and Aronowski, J. (1988). Identification of amino acids involved in the sialidase activity of the mumps virus hemagglutinin-neuraminidase protein. Virology 167: 226-232.

• Kelly, P.T., Weinberger, R.P., and Waxham, M.N. (1988). Active site-directed inhibition of Ca 2+ /calmodulin-dependent protein kinase II by a bifunctional calmodulin-binding peptide. Proc. Natl. Acad. Sci. USA 85: 4991-4995.

• Waxham, M.N. , Aronowski, J., Server, A.C., Wolinsky, J.S., Smith, J.A., and Goodman, H.M. (1988). Sequence determination of the mumps virus HN gene. Virology 164: 318-325.

• Hanley, R.M., Means, A.R., Ono, T., Kemp, B.E., Burgin, K.E., Waxham, N. , and Kelly, P.T. (1987). Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II. Science 237: 293-297.

• Waxham, M.N. , Server, A.C., Goodman, H.M., and Wolinsky, J.S. (1987). Cloning and sequencing of the mumps virus fusion protein gene. Virology 159: 381-388.

• Gonzalez-Scorano, F., Waxham, M.N. , Ross, A., and Hoxie, J.A. (1987). Sequence similarities between human immunodeficiency virus gp41 and paramyxovirus fusion proteins. AIDS Res. Hum. Retro. 3: 245-252.

• Waxham, M.N. , Merz , D.C. , and Wolinsky, J.S. (1986). Intracellular maturation of the mumps virus hemagglutinin-neuraminidase glycoprotein: Conformational changes detected with monoclonal antibodies. J. Virol. 59: 392-400.

• Waxham, M.N. , and Wolinsky, J.S. (1986). A fusing mumps virus variant selected from a nonfusing parent with the neuraminidase inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. Virology 151: 286-295.

• deMazancourt, A., Waxham, M.N. , Nicolas, J.C., and Wolinsky, J.S. (1986). Antibody response to the rubella virus structural proteins in infants with the congenital rubella syndrome. J. Med. Virol. 19: 111-122.

• Server, A.C., Smith, J.A., Waxham, M.N. , Wolinsky, J.S., and Goodman, H.M. (1985). Purification and amino-terminal protein sequence analysis of the mumps virus fusion protein. Virology 144: 378-383.

• Waxham, M.N. , and Wolinsky, J.S. (1985). Detailed immunologic analysis of the structural polypeptides of rubella virus using monoclonal antibodies. Virology 143: 153-165.

• Waxham, M. N. , and Wolinsky, J.S. (1985). A model for the structural organization of rubella virions. Rev. Inf. Dis. 67: S133-S139.

• Wolinsky, J.S., Waxham, M.N. , and Server, A.C. (1985). Protective effects of glycoprotein-specific monoclonal antibodies on the course of experimental mumps virus meningoencephalitis. J. Virol. 53: 727-734.

• Waxham, M.N., and Wolinsky, J.S. (1984) Rubella virus and its effects on the central nervous system. Neurol Clin. 2:367-85.

• Merz , D.C. , Server, A.C., Waxham, M.N. , and Wolinsky, J.S. (1983). Biosynthesis of the mumps virus F glycoprotein: Nonfusing strains efficiently cleave the F glycoprotein precursor. J. Gen. Virol. 64: 1457-1467.

• Waxham, M.N. , and Wolinsky, J.S. (1983). Immunocytochemical identification of rubella virus hemagglutinin. Virology 126: 194-203.

• Schwendemann, G., Wolinsky, J.S., Hatzidimitriou, G., Merz , D.C. , and Waxham, M.N. (1982). Post-embedding immunocytochemical localization of paramyxovirus antigens by light and electron microscopy. J. Histochem. Cytochem. 30: 1313-1319.

• Wolinsky JS, Waxham, M.N., Hess, J.L., Townsend, J.J., Baringer, J.R. (1982) Immunochemical features of a case of progressive rubella panencephalitis. Clin Exp Immunol. 48:359-66.

• Server, A.C., Merz , D.C. , Waxham, M.N. , and Wolinsky, J.S. (1982). Differentiation of mumps virus strains using monoclonal antibody to the HN glycoprotein. Infect. Immun. 35: 179-186.