Herguedas' lab
Structural Biology of neuronal membrane receptors
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Welcome to the Herguedas' lab!
We are a structural biology and biophysics group located at BIFI institute in the University of Zaragoza established in June 2020.
We are interested in understanding membrane proteins at the atomic level, combining protein biochemistry, biophysics and structural biology techniques.
Together with 3 research groups at BIFI we recently created Neuromol (now Neurobiosys!), a group of biophysicists, structural biologists and cell biologists interested in the characterization of proteins involved in neurodegenerative diseases. For more information please visit the Neuromol site.
"Ramón y Cajal" program (Fondo Social Europeo, Agencia Estatal de Investigación). RYC2018-025720-I
"Proyectos Generación de conocimiento" (Agencia Estatal de investigación") PID2022-140185NB-I00
"Proyectos de Consolidación investigadora" Agencia Estal de investigación, Next Generation Funds: CNS2023-145386
NEWS
NEWS
Nueva Publicación del grupo en Nature Structural and Molecular Biology (15/09/2025)
Después de un largo esfuerzo por parte de todos los miembros del grupo, hoy estamos super felices de compartir con vosotros nuestro último trabajo en NSMB. La estructura de GluA4, libre y en complejo con TARP2, atrapada en distintos estados funcionales. Tras las publicaciones recientes de GluA1 y GluA3, el puzle estructural de los receptores AMPAR esta más completo!
Una fantástica colaboración con el grupo de David Soto en la Universidad de Barcelona.
¿No ves nada arriba? Volver a autenticarse
New publication in Nature Structural & Molecular Biology (15/09/2025)
After a long effort from all the members of the group, today we are super happy to share with you our latest work in NSMB: the structure of GluA4, both free and in complex with TARP2, captured in different functional states. Following the recent publications on GluA1 and GluA3, the structural puzzle of AMPAR receptors is becoming more complete!
A fantastic collaboration with David Soto’s group at the University of Barcelona.
Jornadas ASBAR 11/09/2025
Ayer participamos en la jornada de ASBAR con jóvenes estudiantes de los grados y másteres relacionados con la biotecnología y biología molecular en Unizar. Una excelente oportunidad para que los grupos demos a conocer nuestra investigación con los más jóvenes.
Entrevista en Heraldo de Aragón
Programa Agora de Aragón TV
GluA3 structure now out in Nature
(01/07/2025)
A collaboration with Ingo Greger's lab leaded by Aditya Pokharna and Imogen Stockwell,revealed the unique architecture of GluA3. The puzzle of GluA structures is almost closed!
IVA prime server publication
(05/05/2025)
IVA prime is now published in Nucleic Acid Research. Amazing job from Radu Leonte at Sebastian Hiller lab.
IVA cloning oligo design is now super easy!
Premio Extraordinario de máster para Victoria Ribón y Blanca Viguri (15/11/2024)
Victoria Ribón from the group and Blanca Viguri, from Nunilo Cremades' lab, received today the"Premio Extraordinario" of their master degree. Congratulations!
European Researchers Night (27/09/2024)
Irene, Carlos and other members of Neurobiosys group participated at the European Researchers night.
¡Enhorabuena a Victoria Ribón!
Por su Matricula de Honor en el Trabajo Fin de Máster (19/09/2024)
Biophysics Festival in Covilha (09/05/2024)
Irene and Beatriz attended the Biophysics Festival organised by the Portuguese Young Biophysicists in Covilha (Portugal)
Our contribution to Science Dissemination in Heraldo de Aragón (12/03/2024)
We wrote about the potential of Electron Cryo- microscopy in the "Tercer Milenio" section of Heraldo de Aragon.
HA_20240312_Criomicroscopia (1).pdfInternational Day for Women and Girls in Science (02/2024)
Beatriz participated again in the TV program "Buenos días Aragón" to celebrate the international day for women in Science
Irene Sánchez got a PhD Fellowship from DGA (01/01/2024)
We are extremely happy to announce that Irene Sánchez Valls, who was the first person to join the lab, just got a PhD fellowship from DGA. She ensured her funding to continue with her doctoral studies. Congrats!
We got more funding!! (18/07/2023)
We are extremely happy to announce that the Spanish Research Agency just funded our proposal for the next 3 years.
Our project will help us to continue looking into the structural biology of Glutamate Receptors and also get insights into the regulation of neuronal membrane enzymes
Ieva and Victoria's leaving lunch (28/06/23)
Ieva is coming back to Lithuania after her Erasmus + in our lab, where she cloned 4 new genes and learned molecular biology and protein purification techniques
Victoria just finished her degree in the lab, she did an excellent and complex project, she generated and characterised at least 8 mutants, and we have now an optimised protocol for crosslinking
Best of luck in the future!
Beatriz participates in "Soy científica, vivo en tu barrio" (06/02/2023)
The 11th of February is the international day for girls and women in Science. This year we participate in the campaign "I am a scientist, I live in your neighborhood", of the "Unidad de Cultura Científica" at Unizar (https://ucc.unizar.es/)Great activity organized by Carmina Puyod and beautiful pictures by Chus Marchador.
https://ucc.unizar.es/11f-2023/beatriz-herguedas-frances
https://www.elperiodicodearagon.com/aragon/2023/02/06/dia-mujer-nina-ciencia-heroinas-82568265.html
https://alacarta.aragontelevision.es/informativos/buenos-dias-aragon-07022023-0800
https://cadenaser.com/aragon/2023/02/06/me-conoces-soy-cientifica-vivo-en-tu-barrio-radio-zaragoza/
Welcome to Ieva Nekrošiūtė (09/01/2023)
Ieva, from Vilnius University, will expend the next 6 months in the lab, as part of the Erasmus + Traineeship program.
Learning Neuroscience with Jake Watson (13/10/2022)
In the middle of the "fiestas del Pilar" Jake Watson, now a postdoc at Peter Jonas Group, visited us and talk us about his research on neuronal circuits using patch clamp.
We had the opportunity to show him Zaragoza and enjoy the Pilares a lot
Cryo-EM meeting in Madrid- 2nd edition (30/09/2022)
On 30th September 2022 we participated in a new edition of the cryo-EM workshop in Madrid, together with Ernesto Arias, Rafael Fernández Leiro and Javier García's groups. Great discussions about sample preparation with Rafa Nuñez, processing with Rafa Leiro, and beautiful structures from all the labs!
SEBBM 2022 CONFERENCE (06/09/2022)
Carlos is presenting his PhD work at the SEBBM conference in Malaga
New summer student! (04/07/2022)- Victoria Ribón Fuster
Victoria Ribón Fuster, who is studyng the Degree in Biotechnology at Unizar, will stay in the lab for the next four weeks to focus on the cloning of different GluA4 mutants
New summer student! (13/06/2022)- María de Sancha Maluenda
María de Sancha Maluenda, who is studyng the Degree in Biology at Universidad Complutense, will stay in the lab for the next six weeks to focus on the characterization of gria3 mutants involved in disease.
Seminar at Centre for Cryo-electron Microscopy of Membrane Proteins (Melbourne, Australia)
Seminar at Centre for Cryo-electron Microscopy of Membrane Proteins (Melbourne, Australia)
On June 6th I presented the structural work on AMPA receptor heterotetramers in complex with TARP8 published recently in Nature Comms.
We are looking for graduates with Master's degree to join the lab in Autumn 2022
We are looking for graduates with:
Experience in molecular biology, membrane protein structural biology and/or protein biophysics.
A good academic track record or experience with membrane protein biophysics or structural biology
Master's degree required (or more than 300 ECTS)
More info at:
https://docs.google.com/document/d/1pTxaPqCVsYe16K34V-G6s2-CMs5uv4IyHwZUmMl4p3U/edit
New publication (08/02/2022)
Beatriz´s last work at Ingo Greger's lab on AMPAR interactions with TARP-gamma8 in different functional states was finally published in Nature Communications. Together with Bianka Kohegyi we determined the cryo-EM structures of GluA1/2/G8 complex trapped in the open and desensitized states, and combined it with electrophysiology and MD simulations.
Cryo-EM workshop in Zaragoza (19/11/2021)
On 19/11/2021 we organized a meeting together with Ernesto Arias, Rafa Fernández Leiro and Javier García Nafría's group in Zaragoza, where we shared our experiences from cloning to grid preparation and data processing.
The Institute for Biocomputation and Physics of Complex Systems (BIFI) is a Research Institute of the University of Zaragoza. The institute currently has 4 research areas : Biochemistry and molecular and cell biology; Biophysics; Computation and Physics.
The Advanced Microscopy Laboratory located at the same building as BIFI, provide us with the equipment to prepare cryo-EM grids and perform preliminary data collection
Neuromol Seminar
The 6th of June we had a general rehearsal of the presentations of the final research projects performed in the different groups in Neuromol in 2020/2021. Good luck to Irene and Laura in your presentations!
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