INFRASTRUCTURES
The Hyp-ACB facility is a complex infrastructure able to measure, under normoxic and hypoxic conditions, the metabolic activity of living cells, with particular attention to the energy metabolism, in parallel with analysis of gene expression.
The facility allows monitoring cell metabolism and gene expression under variable oxygen tensions, thus reproducing more closely the cell or tissue microenvironment(s) in both physiological and pathological conditions.
The ARP facility is dedicated to the measurement of rapid kinetic processes (micro- to milliseconds) on purified macromolecules in vitro by different spectroscopies (absorbance, fluorescence). Possible applications include analysis of protein folding and denaturation, pre-steady state enzyme reactions, substrate channelling and rapid binding interactions between macromolecules or between a macromolecule and a small ligand (including inhibitors).