Identification of molecular and cellular targets for the development of innovative anti-inflammatory, anti-tumor therapies, and treatments for degenerative diseases through morphological and molecular analyses, including the use of 3D in vitro models.

Study of innovative immunological therapies for chronic inflammatory and autoimmune diseases.

Analysis of the role of "trained immunity" in chronic inflammatory skin diseases: identification of potential checkpoints and new therapeutic targets.

Investigation of the role of inflammation in the development of neurodegenerative diseases and analysis of the epigenetic mechanisms involved in aging and non-communicable diseases, using pharmacological and nutraceutical treatments.

Epigenomics and genomics in complex human pathologies and pathophysiological processes related to cellular aging and environmental stressors.

Identification of key molecules in the differentiation process of pancreatic beta cells, with potential implications for the generation of insulin-producing cells from multipotent precursors and therapeutic strategies for type 1 diabetes. 

Members: Bertagnolo Valeria, Celeghini Claudio, Gemmati Donato, Marci Roberto, Marcuzzi Annalisa, Neri Luca Maria, Rimondi Erika, Romani Arianna, Secchiero Paola, Simioni Carolina, Tisato Veronica

Development of novel non-viral vehicles for innovative therapeutic strategies in personalized medicine targeting neuromuscular diseases.

Creation of genetically modified isogenic cardiac models to study mutational survival bias in Duchenne muscular dystrophy.

Exploration of a multivariate approach to the utilization of biomarkers for neuroinflammation and neurodegeneration.

Investigation of blood biomarkers in neurological diseases.

Identification of new cellular and molecular markers for personalized treatment of aortic valve calcification.

Study of the interaction between NOTCH and the estrogen receptor in endothelial cells and macrophages. 

Members: Bovolenta Matteo, Castellazzi Massimiliano, Cervellati Carlo, Rizzo Paola

Study of interactions between cholangiocarcinoma and the microenvironment to identify clinical biomarkers of treatment response.

Validation of a new method for managing chronic patients with acute respiratory failure.

Pathophysiological evaluation of hemodynamic and respiratory parameters in the perioperative setting.

Clinical implications of the ERAS (Enhanced Recovery After Surgery) protocol.

Members: De Angelis Nicola, Feo Carlo, Occhionorelli Savino, Ragazzi Riccardo, Spadaro Savino, Volta Carlo Alberto 

Study and validation of original syntheses for the production of radiopharmaceuticals and innovative contrast agents "in vitro" on cell lines and "in vivo" on animal models.

Investigation of targeted radiotherapy with CuCl2 for the treatment of peritoneal carcinomatosis: evaluation of the therapeutic efficacy of radionuclides 64Cu and 67Cu. 

Members: Giganti Melchiore, Uccelli Licia 

Study of receptors and their involvement in neurodegenerative, cancerous, and chronic inflammatory diseases.

Investigation of enzyme inhibitors of the endocannabinoid system and histone deacetylases.

Effect of biophysical stimulation in osteoarticular and neurodegenerative diseases.

Development of new molecules as potential anti-cancer and anti-inflammatory drugs. 

Members: Gessi Stefania, Merighi Stefania, Varani Katia, Vincenzi Fabrizio

Clinical studies to standardize the management of patients with coronary microvascular dysfunction.

Study of mental stress and residual risk in myocardial infarction.

Innovative therapies for the treatment of cardiac amyloidosis.

Multimodal imaging in cardiology.

Study of the physiology and clinical benefits of cardiac conduction system pacing.

Investigation of biomarkers and clinical markers in the treatment response of severe obstructive respiratory diseases. 

Members: Bertini Matteo, Campo Gianluca Calogero, Contoli Marco, Papi Alberto, Gianesini Sergio

Development and validation of an integrated risk prediction model for corneal transplant survival after endothelial keratoplasty.

Pilot study for testing a hybrid intra-corneal prosthesis with a scaffold of dehydrated corneal tissue for the treatment of corneal blindness.

Application of genetics and histopathology in the diagnosis and treatment of corneal diseases.

Study of graft survival factors and immunological rejection in lamellar and repeat keratoplasty.

Design of new methods for preserving ocular cells and tissues and validation of devices to improve corneal transplant outcomes.

Study of new pharmacological treatments for retinitis pigmentosa. 

Members: Busin Massimo, Mura Marco, Parmeggiani Francesco, Pellegrini Marco, Yu Angeli Christy 

Development of orthodontic devices using digital design and 3D printing techniques for the treatment of malocclusions in growing and adult patients.

Study of photobiomodulation in oral cavity mucositis.

Validation of antibacterial protocols for the management of periodontitis.

New approaches in dental sleep medicine. 

Members: Caccianiga Gianluigi, Carinci Francesco,  Carra Maria Clotilde, Lauritano Dorina, Lombardo Luca

Study of the impact of grain-free diets and ancient grain-based diets on symptoms, quality of life, and inflammation in patients with Irritable Bowel Syndrome.

Effect of a gluten-free diet on gut microbiome composition in patients with celiac disease, non-celiac wheat sensitivity, and healthy individuals.

Investigation of the postprandial phase and nutraceutical modulation in insulin resistance in patients with diabetes.

Study of cognitive decline in diabetes and chronic kidney disease.

Investigation of new molecular mechanisms in chronic intestinal pseudo-obstruction.

Study of circadian rhythms and chronotypes in the population with a focus on sex/gender-specific differences. 

Members: De Giorgio Roberto, Manfredini Roberto, Passaro Angelina, Zuliani Giovanni, Caio Giacomo Pietro, Caputo Fabio, Sergi Domenico 

Evaluation of the pharmacological and toxicological effects induced by acute and repeated intake of substances with narcotic action, responsible for both acute intoxications and dependency phenomena.

Study of the effects caused by the intake of both well-known substances (morphine, heroin, oxycodone, amphetamines, cocaine, cannabis derivatives, LSD, etc.) and those caused by new psychoactive substances (NPS), such as synthetic cannabinoids, cathinones, and synthetic amphetamine-like stimulants, hallucinogenic phenethylamines, new synthetic opioids (fentanyls and nitazenes), new dissociative anesthetics (methoxpropamine and methoxetamine), and new benzodiazepines.

Forensic toxicology for the identification of substances in biological matrices of intoxicated individuals.

Assessment of medico-legal certifications for political asylum seekers.

Development of operational protocols and emergency practices for gender-based violence. 

Members: Gaudio Rosa Maria, Marti Matteo 

Study of viral and tumor antigens, their generation by cellular proteolytic systems, and molecular recognition by cytotoxic T lymphocytes.

Investigation of vaccine formulations and combinations, with a particular focus on the development of new vaccines against HIV/AIDS and HSV.

Development of synthetic molecules as proteasome inhibitors or potential anti-cancer drugs.

Identification of molecular mechanisms underlying the immunomodulatory effects of the Tat protein.

Study of the molecular processes underlying the aging of the immune system.

Investigation of hospital-acquired infections, the pathogenic mechanisms of infectious diseases, and antimicrobial resistance.

Studies on the human and environmental microbiome.

Study of molecular and immunological host mechanisms in response to viral and bacterial infections in at-risk individuals.

Research on molecules capable of counteracting and containing the pathogenicity and infections caused by bacteria and viruses.

Investigation of bacterial and viral components that can be used as disease biomarkers and therapeutic targets.

Study of emerging and re-emerging infections through the characterization of infectious agents, determination of immune responses, and epidemiological evaluation of pathogenic microorganisms and their variants. 

Members: Bortolotti Daria, Caputo Antonella, Caselli Elisabetta, Gavioli Riccardo, Marconi Peggy Carla Raffaella, Rizzo Roberta

Study of epigenetic modeling of tumor metastases and the tumor immune context to improve the efficacy of immunotherapy.

Integrated multi-omics analysis to identify predictive biomarkers of efficacy/toxicity to biological drugs and immunotherapies.

Investigation of omics and biomarkers in personalized cancer treatment.

Study of the functions and regulation of transglutaminase II.

Research on circulating tumor cells: isolation and characterization. 

Members: Bianchi Nicoletta, Calabrò Luana, Volinia Stefano

Evaluation of the role of ASSR in pediatric audiological diagnosis.

Investigation of the pathophysiological aspects of sudden hearing loss.

Study of new surgical approaches for hyperparathyroidism. 

Members: Bianchini Chiara, Ciorba Andrea, Stomeo Francesco