Literature

Top 10 publications every Medicinal Chemist should read

1. Stahl et al., 2010. A Medicinal Chemist’s Guide to Molecular Interactions. 

2. Fraga et al., 2011. The Methylation Effect in Medicinal Chemistry.

3. Schnider, 2021. Overview of Strategies for Solving ADMET Challenges. 

4. Meanwell and Loiseleur, 2022. Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1.

5. Meanwell and Loiseleur, 2022. Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 2.

6. Meanwell, 2023. Applications of Bioisosteres in the Design of Biologically Active Compounds.

7. Chiodi and Ishihara, 2023. “Magic Chloro”: Profound Effects of the Chlorine Atom in Drug Discovery.

8. Chiodi and Ishihara, 2025. Tertiary Alcohol: Reaping the Benefits but Minimizing the Drawbacks of Hydroxy Groups in Drug Discovery.

9. Chiodi and Ishihara, 2026. Parallels between the chloro and methoxy groups for potency optimization.

10. Edwards, et al., 2018. Lipophilic Efficiency as an Important Metric in Drug Design.