Embedded Files
W-01:
ION MOBILITY SPECTROMETRY
When?: October 29th. 09:00 - 11:00.
Where?: Escuela de Nutrición
Edificio Polivalente Parque Batlle
Address: Av. Ricaldoni S/N
Learning outcomes:
Ion mobility: Basic principles & theory.
Ion Mobility coupled to Mass Spectrometry.
Examples: Chemistry, Biochemistry & Biology.
Drift Tube Ion Mobility
Traveling Wave Ion Mobility
Trapped Ion Mobility
Structures for Lossless Ion Manipulations
W-02:
LIPIDOMOMICS
Tuulia Hyötyläinen - Matej Oresic
When?: October 29th. 13:00 - 15:00.
Where?: Escuela de Nutrición
Edificio Polivalente Parque Batlle
Address: Av. Ricaldoni S/N
Within the metabolomics community, there is growing interest in the comprehensive analysis of lipids (lipidomics), especially in the medical domain. This is because lipid-related disturbances play important roles in the pathogenesis of most of the common diseases. There are many (pre)analytical challenges and considerations that the researchers entering the field of lipidomics need to be aware of, which have been tackled over the past decades within the lipidomics community.
Objectives:
To introduce the key factors that impact human lipid levels as measured by lipidomics, including biological (e.g., diet, circadian rhythm) and preanalytical (e.g., sample collection and storage),
To introduce the analytical techniques, and related challenges, for lipidomic analysis of human biofluids and tissues, including discussion of inter-laboratory comparability and reference ranges.
Learning outcomes:
Understanding of key (pre)analytical and biological factors that may affect the lipid levels in human studies.
Knowledge of key methods for sample collection, preparation and analysis for lipidomics of human biofluids and tissues.
W-03:
BENCHTOP NMR SPECTROSCOPY
José Luis Izquierdo-García - Gonzalo Hernández Dossi
When?: October 29th. 15:30 - 17:30.
Where?: Escuela de Nutrición
Edificio Polivalente Parque Batlle
Address: Av. Ricaldoni S/N
Objectives:
Introduce the Fundamentals of Benchtop NMR Spectroscopy.
Demonstrate the Operation of different Benchtop NMR Spectrometers through Video Tutorials.
Guide Participants in NMR Spectral Interpretation for Metabolomics.
Teach NMR Data Processing and Statistical Analysis Techniques.
Highlight the Clinical Potential and Limitations of Benchtop NMR Technology.
Learning outcomes:
Understand the Core Principles of Benchtop NMR Spectroscopy
Familiarize Themselves with the Operation of different Benchtop NMR System
Develop Competence in Interpreting NMR Spectra for Clinical Applications
Gain Skills in Processing and Analyzing NMR Data
Critically Assess the Clinical Utility of Benchtop NMR
W-04:
Hands-on mzmine
When?: October 30th. 09:00 - 11:30.
Where?: Torre de las Telecomunicaciones
Auditorio Mario Benedetti
Address: Guatemala 1075
This hands-on workshop will provide an overview of mass spectrometry data processing in mzmine using an example dataset.
Objectives:
Introducing untargeted metabolomics LC-MS/MS data processing in mzmine with the Processing Wizard (MZwizard)
Feature detection, compound annotation, and molecular networking in mzmine
Exporting results from mzmine to interface other tools like SIRIUS and GNPS
W-05:
Unveiling the mQACC Living Guidance for QA/QC Best Practices in LC-MS-Based Untargeted Metabolomics
Dajana Vuckovic - Julia Kuligowski - María Eugenia Monge
When?: October 30th. 13:00 - 15:00.
Where?: Torre de las Telecomunicaciones
Auditorio Mario Benedetti
Address: Guatemala 1075
Objectives:
To disseminate findings from the mQACC Best Practices Working Group’s extensive community engagement efforts to establish best practices for LC-MS data collection in untargeted metabolomics.
To solicit further feedback from the Latin American metabolomics community on the open-access best practices living guidance document that will be freely accessible to researchers.
Learning Outcomes:
Attendees will learn about minimum and best practices for untargeted LC-MS-based metabolomics as proposed in living guidance by mQACC Best Practices Working Group.
The guidance covered will include pooled QC, internal standards, and design of analytical batch.
Attendees will be able to identify how to participate in mQACC, including mechanisms to contribute to the best practices community engagement efforts and living guidance document.
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