Wernimont Lab

The Wernimont lab is focused on unraveling the mechanisms through which alterations in maternal nutrient availability impact placental development and contribute to adverse pregnancy outcomes.  As part of this research, we combine cutting-edge static and isotope tracing metabolomics with targeted gene disruption in trophoblast cell models to define how mitochondrial nutrient flux regulates metabolic, epigenetic, and transcriptional reprogramming events during trophoblast differentiation.  Additionally, we investigate how gestational diabetes regulates trophoblast differentiation and function to impact health outcomes in pregnancy and beyond.  Finally, our clinical research team investigates how to improve care delivery for individuals with diabetes in pregnancy in order to improve long-term health outcomes for families.