139. Wang, Yiao, Distefano, Mark, and Wagner, Carston R., “Targeted Drug Delivery by MMAE Farnesyl Bioconjugated Multivalent Chemically Self-Assembled Nanorings Induces Potent Receptor Dependent Immunogenic Cell Death”, Bioconjugate Chemistry, 35, 5, 582-592 (2024).
138. Li, Jiaqian; Wang, Yiao, Distefano, Mark, Wagner, Carston R. and Pomerantz, William "Multivalent Fluorinated Nanorings for On-Cell 19F NMR", Biomacromolecules, 25, 2, 1330–1339 (2024).
137. Li, Jiaqian, Kirberger, Steven E., Wang Yiao, Cui, Huarui, Distefano, Mark, Wagner, Carston R., and Pomerantz, Willian C. K.“Design of Highly Fluorinated Peptides for Cell-based 19F NMR”, Bioconjugate Chemistry, 34, 8, 1477–1485 (2023).
136. Dillenburg, Maxwell, Smith Jacob, and Wagner, Carston R., “The Many Faces of Histidine Triad Nucleotide Binding Protein 1”, ACS Pharmacology & Translational Science, 6, 10, 1310–1322 (2023).
135. Istomine, Roman, AlAubodah, Tho-Alfakar, Alvarez, Fernando, Smith, Jacob A., Wagner, Carston, R., Piccirillo, Ciriaco A., “The eIF4EBP-eIF4E axis regulates CD4+ T cell differentiation through modulation of T cell activation and metabolism”, iScience, 26, 5, 106683 (2023).
134. Petersburg, Jacob R., Vallera, Daniel, and Wagner, Carston R., “Eradication of Heterogenous Tumors by T-cells Targeted with Combination Bispecific Chemically Self-Assembled Nanorings (CSANs)”, Molecular Cancer Therapeutics, 28, 371-380 (2023).
133. Wang, Yiao, Rozumalski, Lakmal, Lichtenfels, Caitlin, Petersberg, Jacob R., Kilic, Ozgun, Distefano, Mark D., Wagner, Carston R., “Engineering Biomimetic Trogocytosis with Farnesylated Chemically Self-Assembled Nanorings”, Biomacromolecules, 23, 12, 5018–5035 (2022).
132. Strom, Alexander, Shah, Rachit, Dolot, Rafal, Rogers, Melanie S., Tong, Cher-Ling, Wang, David, Xia, Youlin, Lipscomb, John D., Wagner, Carston R., “Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis in Human Histidine Triad Nucleotide Binding Proteins”, Biochemistry, 61, 23, :2648-2661 (2022).
131. Wang, Yiao, Wagner, Carston R., Distefano, Mark D., “Manipulating Cell Fates with Protein Conjugates”, Bioconjugate Chemistry, 33, 10, 1771–1784 (2022).
130. Mews, Ellie A., Beckmann, Pauline J., Patchava, Mahathi, Wang, Yiao, Largaespada, David A., Wagner, Carston R., “Multivalent, Bispecific αB7-H3-αCD3 Chemically Self-Assembled Nanorings Direct Potent T-cell Responses Against Medulloblastoma”, ACS Nano, 16, 8, 12185-12201, (2022).
129. Jacobson, Blake A., Ahmad, Zeeshan, Chen, Sierra, Waldusky, Gabriella, Dillenburg, Maxwell, Stoian, Emilia, Cambron, Daniel A, Patel, Anil J., Patel, Manish R., Wagner, Carston R., Kratzke, Robert A., “4Ei-10 Interdiction of Oncogenic Cap-Mediated Trranslation as Therapy for Non-Small Cell Lung Cancer”, Investigational New Drugs, 39, 636-643 (2021).
128. Strom, Alexander, Shah, Rachit and Wagner, Carston R., "Switching On" Enzyme Substrate Specificity Analysis with a Fluorescent Competitive Inhibitor, Biochemistry, 60, 440-450 (2021).
127. Wang, Yiao , Kilic, Ozgun, Csizmar, Clifford M., Ashok, Sudhat, Hougland, James L. Distefano, Mark D., Wagner, Carston R., “Engineering Reversible Cell-Cell Interactions Using Enzymatically Lipidated Chemically Self-Assembled Nanorings”, Chemical Sciences, 12, 331-340 (2021).
126. Ahmad, Zeeshan, Chen, Sierra, Waldusky, Gabriella, Dillenburg, Maxwell, Jacobson, Blake A., Stoian, Emilia, Cambron, Daniel A., Patel, Anil J., Patel, Manish R., Wagner, Carston R. and Kratzke, Robert A., 4ei-10 Interdiction of Oncogenic Cap-Mediated Translation as Therapy for Non-Small Cell Lung Cancer, Investigational New Drugs, 39, 636-643 (2020).
125. Kilic, Ozgun, Matos de Souza, Marcos R., Almotlak, Abdulaziz A., Wang, Yiao, Siegfried, Jill M., Distefano, Mark D. and Wagner, Carston R. “Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T Cell Mediated Antitumor Responses and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression”, Journal of Medicinal Chemistry, 63,10235-10245 (2020).
124. Matos de Souza, Marcos Romário, Cunha, Marcela Sabino, Okon, Aniekan, Lima Monteiro, Fábio Luís, Campanati, Loraine, Wagner, Carston R. and da Costa, Luciana Jesus, “In Vitro and In Vivo Characterization of the Anti-Zika Virus Activity of ProTides of 2′-C-β-Methylguanosine”, ACS Infectious Disease, 6, 1650-1658 (2020).
123. Schwarz, Daniel M. C., Williams, Sarah K., Dillenburg, Maxwell, Wagner, Carston R. and Gestwicki, Jason E., “A Phosphoramidate Strategy Enables Membrane Permeability of a Non-Nucleotide Inhibitor of the Prolyl Isomerase Pin-1”, ACS Medicinal Chemistry Letters, 11, 9 1704-1710 (2020).
122. Csizmar, Clifford M; Wagner, Carston R. “Engineering Reversible Cell-Cell Interactions with Chemical Biology”, Method of Enzymology, Editor, David M. Chenoweth, 638, 167-190 (2020).
121. Strom, Alexander, Tong, Cher-Ling and Wagner, Carston R., “Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A”, FEBS Letters, 594, 10, 1497-1505, (2020).
120. Noor, Shahani, Sanchez, Joshua J., Sun, Melody S., Pervin, Zinia, Sanchez, Jacob E., Havard, Mara A., Epler, Lauen T., Nysus, Monique, V., Norenberg, Jeffrey P., Wagner, Carston R., Davies, Suzy, Wagner, Jennifer L., Savage, Daniel, D., Jantzie, Lauren L., Mellios, Nikolaos and Milligan, Erin D., The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions, Brain, Behavior and Immunity, 87, 3390358 (2020).
119. Cleuren, Yamila N. Torres; Tjeldnes, Hakon; Krause, Maximilian; Bizuayehu, Teshome Tilahun; Giess, Adam; Torres Cleuren, Yamila N; Tjeldnes, Håkon; Hiensch, Senna; Okon, Aniekan; Wagner, Carston R; Valen, Eivind, Profiling of Small Ribosomal Subunits Reveals Modes and Regulation of Translation Initiation, Cell Reports, 31, 3, 107534, (2020).
118. Ahmad Zeeshan, Jacobson Blake A., McDonald Mitchell W., Vattendahl, Nicholas V., Vattendahl, Gabriel V., Chen, Sierra, Dillenburg, Maxwell, Okon, Aniekan M., Patel, Manish R., Wagner, Carston R. and Kratzke, Robert A., “Repression of oncogenic cap-mediated translation by 4Ei-10 diminishes proliferation, enhances chemosensitivity and alters expression of malignancy-related proteins in mesothelioma”, Cancer Chemotherapy and Pharmacology, 85, 2, 425-432. doi: 10.1007/s00280-020-04029-9, (2020).
117. Shah, Rachit M., Peterson, Cristina, Strom, Alexander, Dillenburg, Maxwell, Finzel, Barry, Kitto, Kelley F., Fairbanks, Carolyn, Wilcox, George and Wagner, Carston R. “Inhibition of Hint1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice”, ACS Chemical Neuroscience, 10,4385-4393 (2019).
116. Noor, Shani, Sun, Melody S., Vanderwall, Arden G., Havard, Mara A., Sanchez, Jacob E., Harris, Nathan W., Nysus, Monique V., Norenberg, Jeffrey P., West, Harrison T., Wagner, Carston R. Jantzie, Lauren L., MellioS, Nikolaos, Milligan, Erin D., "LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes, Neuroimmunology Neuroinflammation; 6:10 DOI: 10.20517/2347-8659.2019.18 9 (2019).
115. Sanchez, J. J., Sanchez, J. E., Noor, S., Ruffaner-Hanson, C. D., Davies, S, Wagner, C. R., Jantzie, L. L., Mellios, N., Savage, D. D., Milligan, E. D., “Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure”, Acta Neuropathology Commun. 7(1):54. doi: 10.1186/s40478-019-0701-y, (2019).
114. Csizmar, Clifford M., Petersburg, Jacob R., Perry, Thomas J., Rozumalski, Lakmal, Hackel, Benjamin J., Wagner, Carston R.,,"Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density”, J. Amer. Chem. Soc. 141, 251-261 (2019).
113. Mota, Roberto, Campen, Matthew J., Cuellar, Matthew E., Garver, William S., Hesterman, Jacob, Qutaish , Mohammed, Daniels, Tamara, Nysus, Monique, Wagner, Carston R. and Norenberg, Jeffrey P., “111In-DANBIRT In Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis”, Contrast Media & Molecular Imaging, Article ID 6508724 (2018).
112. Petersburg, Jacob R., Jingjing Shen, Jingjing, Csizmar, Clifford M., Murphy, Katherine A Spanier, Justin, Gabrielse, Kari, Griffith, Thomas S., Fife, Brian and Wagner, Carston R., “Eradication of Established Tumors by Chemically Self-Assembled Nanoring (CSAN) Labelled T-Cells”, ACS Nano, 12, 6563–6576 (2018).
111. Shah, Rachit M., Maize, Kimberly M., West, Harrison T., Strom, Alexander M., Barry C. Finzel, Barry C. , and Wagner, Carston R., “Structure and Functional Characterization of Human Histidine Triad Nucleotide Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia”, Journal of Molecular Biology, 430, 2709-2721 (2018).
110. Csizmar, Clifford, M., Petersburg, Jacob R., and Wagner, Carston R., “Programming Cell-Cell Interactions Through Non-Genetic Membrane Engineering”, Cell Chemical Biology, 25, 931-940 (2018).
109. West, Harrison T., Csizmar, Clifford M., and Wagner, Carston R., “Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation”, Biomacromolecules, 19, 2650-2656 (2018).
108. Csizmar, Cliff M., Petersburg, Jacob R., Hendricks, A., Stern, Lawrence A., Hackel, Benjamin J., and Wagner, Carston R.. “Engineering reversible cell-cell interactions with lipid anchored prosthetic receptors”, Bioconjugate Chemistry, 18, 1291-1301 (2018).
107. Harris, Benjamin, R.E., Wang, Defeng, Zhang, Ye, Ferrari, Marina, Okon, Aniekan, Cleary, Margot P., and Wagner, Carston R., Yang, Da-Qing, “Induction of the p53 tumor suppressor in cancer cells through inhibition of cap-dependent translation”, Molecular & Cellular Biology, 38, 10, e00367-17 (2018).
106. Shah, Rachit, Zhou, Andrew and Wagner, Carston R., "Switch-on fluorescent/FRET probes to study human histidine triad nucleotide binding protein 1 (hHint1), a novel target for opioid tolerance and neuropathic pain", Organic & Biomolecular Chemistry, (2017) DOI: 10.1039/C7OB02472J.
105. Maize, Kim M., Shah, Rachit, Strom, Alex, Kumarapperuma, Sidath C., Zhou, Andrew Li, Wagner, Carston R. and Finzel, Barry C. "A Crystal Structure-Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides", Molecular Pharmaceutics, 14, 3987-3997 (2017).
104. Okon, Aniekan, Han, JingJing Dawadi, Surendra, Demosthenous, Christos, Aldrich, Courtney C., Gupta, Mamta and Wagner, Carston R., "Anchimerically Activated ProTides as Inhibitors of Cap-dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma”, Journal of Medicinal Chemistry, 60, 8131-8144 (2017).
103. Okon, Aniekan, Romário Matos de Souza, Marcos, Shah, Rachit, Amorim, Raquel Jesus da Costa, Luciana and Wagner, Carston, R., “Anchimerically Activated Antiviral ProTides”, ACS Medicinal Chemistry Letters, 8, 958–962 (2017).
102. Shah R., Chou Tsuifen, Maize, Kimberly M., Strom, Alexander, Finzel, Barry C., Wagner, Carston R., "Inhibition by Divalent Metal Ions of Human Histidine Triad Nucleotide Binding Protein1 (hHint1), a Regulator of Opioid Analgesia and Neuropathic Pain", Biochemical and Biophysical Research Communications, 491, 760-766 (2017).
101. Shah, Rachit, Maize, Kimberly M., Zhou, Xin, Finzel, Barry C., Wagner, Carston R., "Caught Before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)", Biochemistry, 56, 3559-3570 (2017).
100. Stern, Lawrence A., Csizmar, Clifford M., Woldring, Daniel R., Wagner, Carston R., and Hackel, Benjamin J., “Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands”, ACS Combinatorial Science 19, 315-323 (2017).
99. Shah, Rachit, Petersburg, Jacob, Gangar, Amit C., Fegan, Adrian, Wagner, Carston R., and Kumarapperuma, Sidath C., “In Vivo Evaluation of Site-Specifically PEGylated Chemically Self-Assembled Protein Nanostructures”, Molecular Pharmaceutics, 13, 2193–2203 (2016).
98. Shah, Rachit, Strom, Alexander, Zhou, Andrew Zhou, Maize, Kimberly M., Finzel, Barry C., and Wagner, Carston R., “Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1", ACS Med. Chem. Letters”, 7, 780–784 (2016).
97. Smith, Karen A., Zhou, Bo, Avdulov, Svetlana, Benyumov, Alexey, Peterson, Mark, Liu, Yi, Okon, Aniekan, Hergert, Paul, Braziunas, Jeffrey, Wagner, Carston R., Borok, Zeda and Bitterman, Peter B., “Transforming Growth Factor-b1 Induced Epithelial Mesenchymal Transition Is Blocked By A Chemical Antagonist Of Translation Factor EIF4E”, Scientific Reports, 5, 18233 (2015) doi:10.1038/srep18233.
96. Shen, Jingjing, Vallera, Daniel A., and Wagner, Carston R., “Prosthetic Antigen Receptors”, J. Amer. Chem. Soc.,137, 10108-10111 (2015).
95. Garzon , Javier, Herrero-Labrador, Raquel, Rodríguez-Mu~noz, Maria, Shah, Rachit, Vicente-Sanchez, Ana, Wagner, Carston R., Sanchez-Blazquez, Pilar, “HINT1 protein: A new therapeutic target to enhance opioid antinociception and block mechanical allodynia”, Neuropharmacology, 89, 412-423 (2015). http://www.sciencedirect.com.ezp3.lib.umn.edu/science/article/pii/S0028390814003979.
94. Chen Esther Z., Jacobson Blake A., Patel Manish R., Okon Aniekan M., Li Shui, Xiong Kerry, Vaidya Abhishek J., Bitterman Peter B., Wagner Carston R., Kratzke Robert A., “Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells”, Investigational New Drugs. 4, 598-603 (2014). http://link.springer.com.ezp3.lib.umn.edu/article/10.1007/s10637-014-0076-7.
93. Gabrielse, Kari, Gangar, Amit, Kumar, Nigam, Lee, Jae Chul, Fegan, Adrian, Shen, Jing Jing, Li, Qing, Vallera, Daniel A. and Wagner, Carston R., “Reversible Re-programming of Cell-Cell Interactions”, Angewante Chemie (International. Ed.) 53, 5112-5116 (2014).
92. Cao, Ji, He, Lingjuan, Lin, Guanyu, Hu,Chunqi, Dong, Rong, Zhang, Jun, Zhu, Hong, Hu, Yongzhou, Wagner, Carston R., He, Qiaojun, Yang, Bo, “Cap-dependent Translation Initiation Factor, eIF4E, is the Target for Ouabain-Mediated Inhibition of HIF-1α”, Biochem. Pharmacol.
91. Rashidian, Mohammad, Kumarrapperuma, Sidath, Gabrielse, Kari, Fegan, Adrian, Wagner, Carston R. and Distefano, Mark D., “Simultaneous Dual Protein Labeling using a Triorthogonal Reagent," J. Amer. Chem. Soc, 135, 16388-16396 (2013).
90. Gangar, Amit, Fegan, Adrian, Kumarapperuma, Sidath, Huynh, Peter, Benyumov, Alexey and Wagner, Carston R. “Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures (CSANs),” Mol. Pharmaceutics 10, 3514-3518 (2013).
89. Maize, Kimberly J., Wagner, Carston R., Finzel, Barry, "Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily," FEBS Journal, 280, 3389–3398 (2013).
88. Zhou, Xin, Chou, Tsui-Fen, Aubol, Brandon, Park, Chin-Ju, Wolfenden, Richard, Adams, Joseph, Wagner, Carston R., “Kinetic Mechanism of Human Histidine Triad Nucleotide Binding Protein 1 (Hint1)”, Biochemistry, 52, 3588–3600 (2013).
87. Bjur, Eva, Larsson, Ola, Yurchenko, Ekaterina, Zhang, Lei, Gandin, Valentina, Topisirovic, Ivan, Li, Shui, Wagner, Carston R., Sonenberg, Nahum and Piccirillo, Ciriaco A., “Distinct Translational Control in CD4+ T-cell Subsets”, PLOS Genetics, 10.1371/journal.pgen.1003494 (2013).
86. Rashidian, Mohammad, Mahmoodi, Mohammad M., Shah, Rachit, Dozier, Jonathan K. Wagner, Carston R. and Distefano, Mark D., “A Highly Efficient Catalyst for Oxime Ligation and Hydrazone–Oxime Exchange Suitable for Bioconjugation”, Bioconjugate Chem., 24, 333-343 (2013).
85. Li, Shui, Jia, Yan, Jacobson, Blake, McCauley, Joel, Kratzke, Robert, Bitterman, Peter E., and Wagner, Carston R., “Treatment of Breast and Lung Cancer Cells with a N-7 Benzyl Guanosine Monophosphate Tryptamine Phosphoramidate Pronucleotide (4Ei-1) Results in Chemosensitization to Gemcitabine and Induced eIF4E Proteasomal Degradation”, Mol. Pharmaceutics 10, 523–531 (2013).
84. Fegan, Adrian, Kumarapperuma, Sidath, and Wagner, Carston R. “Chemically Self-assembled Antibody Nanostructures as Potential Drug Carriers”, Mol. Pharmaceutics 9, 3218–3227 (2012).
83. Shah, Neha B., White, James G, Fegan, Adrian, Vercellotti, Gregory M., Wagner, Carston R. and Bischof, John C., “Blood-Nanoparticle Interactions and In Vivo Biodistribution: Impact of Surface PEG and Ligand Properties”, Mol. Pharmaceutics, 8: 2146-2155 (2012).
82. White, Brian R., Carlson, Jonathan C. T., Kerns, Jesse, and Wagner, Carston R., “Protein Interface Remodeling in a Chemically Induced Protein Dimer”, J. Molecular Recognition 25:393-403 (2012).
81. Jia, Yan, Polunovsky, Vitaly, Bitterman, Peter B., and Carston R. Wagner, “Cap-dependent Translation Initiation: An Emerging Anticancer Drug Target”, Medicinal Res. Reviews, (2012), (ASAP), DOI: 10.1002/med.212260
80. Ganger, Amit, Fegan, Adrian, Kumarapperuma, Sidath C. and Wagner, Carston R., “Programmable Self-Assembly of Antibody-Oligonucleotide Conjugates as Small Molecule and Protein Carriers”, J. Amer. Chem. Soc., 134, 2895-2897 (2012).
79. Bardaweel, Sanaa, Ghosh, Brahma, and Wagner, Carston R., “Synthesis and evaluation of potential inhibitors of human and Escherichia coli”, Bioorg. Med. Chem. Letters, 22, 558-560 (2011).
78. Birkus, Gabriel, Kutty, Nilima, Frey, Christian R., Shribata, Riri, Chou, Tsui-Fen, Wagner, Carston R., McDermott, Martin and Cihlar, Tomas. “Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Antipapillomavirus Agent GS-9191”, Antimicrob. Agents Chemother., 55, 2166-2173 (2011).
77. White, Brian R, Li, Qing, and Wagner, Carston R., “Chemically induced self-assembly of enzyme nanorings”, Methods Mol. Biol., 743:17-26 (2011).
76. Bardaweel, Sanaa, Ghosh, Brahma, Chou, Tsui-Fen, Sadowsky, Michael, and Wagner, Carston R., “Hint, A Histidine Triad Nucleotide Binding Proteins, is Essential for Alanine Metabolism in Escherichia coli,” Plos One, 6, (2011) doi:10.1371/journal.pone.0020897.
75. Bardawell, Sanaa, Pace, J., Chou, Tsui-fen, Cody, Vivian and Wagner, Carston R., “Probing the Impact of the EchinT C-terminal Domain on Structure and Catalysis”, J. Mol. Biol., doi:10.1016/j.jmb.2010.09.066, (2010).
74. Li, Qing, So, Christopher, Fegan Adrian, Sarikaya, Mehmet, and Vallera, Daniel A., “Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic”, J. Amer. Chem. Soc. DOI: 10.1021/ja107153a (2010).
73. Fegan, Adrian, White, Brian R., Carlson, Jonathan C. T. and Wagner, Carston "Chemically Controlled Protein Assembly: Techniques and Applications," Chem. Rev., 2010, 110 (6), pp 3315–3336 DOI: 10.1021/cr8002888.
72. Design, Synthesis and Evaluation of Analogs of Initiation Factor 4E (eIF4E) Cap Binding Antagonist Bn7-GMP, European J. Medicinal Chem., 45, 1304–1313 (2010).
71. Zhang, Hua, Zeng, Xianke, Li, Qing, Gaillard-Kelly, Martine, Wagner, Carston R., and Yee, Douglas, “Fluorescent tumor imaging of type I IGF receptor (IGF1R) in vivo: comparison of antibody-conjugated quantum dots and small molecule fluorophore,” British Journal of Cancer, 101, 71-79 (2009).
70. Zhou, Xin, Zhang, Naixia, Liu, Li, Walters, Kylie, J., Hanna, Patrick E. and Wagner, Carston R., “Probing the Catalytic Potential of the Hamster Arylamine N-Acetyltransferase 2 Catalytic Triad by Site-directed Mutagenesis of the Proximal Conserved Residue, Tyrosine 190,” FEBS Journal, 276, 6928-6941 (2009).
69. Cheng, Jilin, Zhou, Xin, Chou, Tsui-fen, Ghosh, Brahma, Liu, Baoling, and Wagner, Carston R., “Identification of the Amino Acid-AZT-Phosphoramidase by Affinity T7-phage Display Selection,” Bioorg. Med. Chem. Letts, 19, 6379-6381 (2009).
68. Liu, Li, Wagner, Carston R., and Hanna, Patrick E., “Isoform Selective Inactivation of Human Arylamine N-Acetyltransferases by Reactive Metabolites of Environmental Arylamines,” Chem. Res. Tox., 22, 1962-1974 (2009).
67. Ghosh, Brahma, Benyumov, Alexey O., Ghosh, Phalguni, Avdulov, Svetlana, Jia, Yan, Dahlberg, Peter S., Peterson, Mark, Smith, Karen, Polunovsky, Vitaly A., Bitterman, Peter B., and Wagner, Carston R.,"Non-Toxic Chemical Interdiction of the Epithelial-to-Mesenchymal Transition by Targeting Cap-dependent Translation," ACS Chemical Biology, 4, 367-377 (2009).
66. Zhang, Hua, Zeng, Xianke, Li, Qing, Gaillard-Kelly, Martine, Wagner, Carston R., and Yee, Douglas, "Fluorescent tumor imaging of type I IGF receptor (IGF1R) in vivo: comparison of antibody-conjugated quantum dots and small molecule fluorophore," British Journal of Cancer, 101, 71-79 (2009).
65. Chou, Tsui-Fen, So, Christopher, Carlson, Jonathan T. C., White, Brian R., Sarikaya, Mehmet, and Wagner, Carston, "Enzyme Nanorings", ACS Nano, 2, 2519-2525 (2008). (Highlighted paper)
64. Li, Qing, Hapka, David, Chen, Hua, Vallera, Daniel A. and Wagner, Carston R., "Self-Assembling Antibodies by Chemical Induction" Angewante Chemie (International. Ed.) 47, 10179-10182 (2008).
63. White, Brian, Wagner, Carston, Truhlar, Donald, and Amin, Elizabeth "Molecular Modeling of Geometries and Charge Distributions of Small, Drug-Like Molecules Containing Nitrogen Heterocycles and Exocyclic Amino Groups in the Gas Phase and Aqueous Solution", Journal of Chemical Theory & Computation, 4, 1718-1732 (2008). (Selected for issue Cover)
62. Liu Li, Wagner, Carston R., and Hanna, Patrick E., "Human Arylamine N-Acetyltransferase 1: In Vitro and Intracellular Inactivation by Nitrosoarene Metabolites of Toxic and Carcinogenic Arylamines", Chemical Research & Toxicology 21, 2005-2016 (2008).
61. Ghosh, Phalguni, Cheng, Jilin, Chou, Tsui-Fen, Jia, Yan, Avdulov, Svetlana, Bitterman, Peter B., Polunovsky, Vitaly A., and Wagner, Carston R.. "Expression, Purification and Characterization of Recombinant Mouse Translation Initiation Factor eIF4E as a Dihydrofolate Reductase (DHFR) Fusion Protein", Protein Expression & Purification, 60,132-139, (2008).
60. Chou, Tsui-fen, Cheng, Jilin, Tikh, Ilya B., and Wagner, Carston R.,"Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily", Journal of Molecular Biology, 373, 4, 978-89 (2007).
59. Chou, Tsui-fen, Sham, Y., and Wagner, Carston R., "The Impact of the C-Terminal Loop of Histidine Triad Nucleotide Binding Protin1 (Hint1) on Substrate Specificity", Biochemistry, 46, 13074-13079 (2007).
58. Chou, Tsui-fen and Wagner, Carston R.,"Engineered Monomeric Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Hydrolyzes Fluorogenic Acyl -Adenylate and Lysyl-tRNA Synthetase Generated Lysyl-Adenylate", Journal of Biological Chemistry, 282, 20, 15137-15147 (2007).
57. Liu, Li, Von Vett, Annette, Zhang, Naixia, Walters, Kylie J., Wagner,and Hanna, Patrick E., "Arylamine N-Acetyltransferases: Characterization of the Substrate Specificities and Molecular Interactions of Environmental Arylamines with Human NAT1 and NAT2", Chemical Research & Toxicology,20, 9, 1300-8 (2007).
56. Minchin, RobertF, Hanna Patrick E, Dupret Jean-M, Wagner Carston R, Rodrigues-Lima F, Butcher Neville J., "Arylamine N-acetyltransferase I", International Journal of Biochem. Cell Biol., 39, 11, 1999-2005 (2007).
55. Chou, Tsui-fen, Baraniak, Janina, Kaczmarek, Renata, Zhou, Xin, Cheng, Jilin, Ghosh, Brahma, Wagner, Carston R., "Phosphoramidate Pronucleotides: A Comparison of the Phosphoramidase Substrate Specificity of Human and Escherichia coli Histidine Triad Nucleotide Binding Proteins",Mol. Pharmaceutics, 4 (2), 208-217, (2007).
54. Chou, Tsui-fen and Wagner, Carston R.," Lysyl-tRNA Synthetase Generated Lysyl-Adenylate is a Substrate for Histidine Triad Nucleotide Binding Proteins (Hints)", Journal of Biological Chemistry,282, 7, 4719-4727 (2007).
53. Poria, Rahul B., Norenberg, Jeffrey P., Anderson, Tamara L., Erion, Jack, Wagner, Carston R., Arterburn, Jeffrey B., Larson, Richard S., "Characterization of a Radiolabeled Small Molecule Targeting Leukocyte Function-Associated Antigen-1 Expression in Lymphoma and Leukemia",Cancer Biotherapy & Radiopharmaceuticals, 21, 5, 418-426 (2006).
52. Zhang, Naxia, Liu, Li, Liu, Fen, Wagner, Carston R., Hanna, Patrick E., Walters, Kylie J., "NMR-based Model Reveals the Structural Determinants of Mammalian Arylamine N-Acetyltransferase Substrate Specificity," J. Mol. Biol., 363, 188-200 (2006).
51. Liu, Fen, Zhang, Naixia, Zhou, Xin, Hanna, Patrick E., Wagner, Carston R., Koepp, Deanna M. and Walters, Kylie J., "Arylamine N-acetyltransferase Aggregation and Constitutive Ubiquitylation," J. Mol. Biol., 361, 482-492 (2006).
50. Carlson, Jonathan T. C., Jenna, Sidhartha, Flenniken, Michelle, Chou, Tsui-fen, Siegel, Ronald, and Wagner, Carston R.,“Chemically Controlled Self-Assembly of Protein Nanorings,” Journal of the American Chemical Society, 128, 7630-7638, (2006).
49. Ghosh, Phalguni, Park, Chunkyung, Peterson, Mark A., Bitterman, Peter B, Polunovsky, Vitaly A., Wagner, Carston R., "Synthesis and Evaluation of Potential Inhibitors of eIF4E Cap Binding to 7-mehyl GTP," Bioorganic & Medicinal Chemistry Letters 15, 2177-2180 (2005).
48. Wang, Haiqing, Hanna, Patrick E., and Wagner, Carston R., “The Catalyitic Mechanism of Hamster Arylamine N-Acetyltransferase 2,” Biochemistry, 44, 11295-11306, (2005).
47. Kim, Jisook, Park, Soobong, Tretyakova, Natalia Y. and Wagner*, Carston R., "A Method for Quantitating the Intracellular Metabolism of AZT Amino Acid Phosphoramidate Pronucleotides by Capillary High-performance Liquid Chromatography-Electrospray Ionization MassSpectrometry,"Molecular Pharmaceutics, 2, 233-241 (2005).
46. Chou, Tsui-fen, Cheng, Jilin, Bieganowski, Pawel, Brenner, Charles and Wagner, Carston R. “31P NMR and Genetic Analysis Establish hinT as the Only E. coli Purine Nucleoside Phosphoramidase and as Essential for Growth under High Salt Conditions,” J. Biol. Chem ., 280, 15356-15361, (2005).
45. Ghosh, Phalguni, Park, Jun, Peterson, Mark, Bitterman, Peter B., Polunovsky, Vitaly A., "Design and Synthesis of 7-Methyl Guanosine Phosphate Analogs as Inhibitors of eIF4E,” Bioorganic & Medicinal Chemistry Letters, 15, 2177-2180, (2005).
44. Wang, Haiqing, Vath, Gregory, Bates, Caleb, Hanna, Patrick E., and Wagner, Carston R., "Over-expression and Purification of Recombinant Human Arylamine N-Acetyltransferase 1," The Protein Journal, 24, 65-77, (2005).
43. Larson Richard S., Davis, Terry, Li, Yu, Oprea, Tudor, Semenuk, Gloria, Chiagev, Alexander, Sklar, Larry and Wagner, Carston R., “Dissociation of I domain and global conformational changes in LFA-1: Refinement of small molecule-I domain structure-activity relationships,” Biochemistry 44(11), 4322-4331, (2005).
42. Wang, Haiqing, Wagner, Carston R., and Hanna, Patrick E., "Irreversible Inactivation of Arylamine N-Acetyltransferases in the Presence of N-Hydroxy-4-Acetylaminobiphenyl: A Comparison of Human and Hamster Enzymes,” Chemical Res. Toxicology, 18, 183-197, (2005).
41. Kawamura, A. Kane, Graham, James, Mushtaq, Adeel, Stefanos A.Tsiftsoglou, Stefanos A.. Vath, Gregory, M., Hanna, Patrick E., Wagner, Carston R. and Sim*, Edith, “Eukaryotic arylamine N-acetyltransferase: Investigation of substrate specificity by high-throughput screening,”Biochemical Pharmacology, 69, 347-359, (2005).
40. Annis, D. Allen, Athanasopoulos, John, Birnbaum, Seth N., Curran, Patrick J., Demby, Cameron, Felsch, Jason S., Kalghatgi, Krishna, Lee, William H., Nash, Huw M., Shipps, Gerald, W., Tyler, Andrew N., Thuduppathy, Guruvasuthevan. R., Wagner, Carston R., and Wintner, Edward A., "An Affinity Selection-Mass Spectral Method for the Identification of Small Molecule Ligands from Self-Encoded Combinatorial Libraries. Discovery of a Novel Antagonist of E. coli Dihydrofolate Reductase," Int. J. Mass Spectrometry, 238 (2): 77-83, (2004).
39. Wang, Haiqing, Vath, Gregory, Gleason, Kara J., Hanna, Patrick E., and Wagner, Carston R.,“Probing the Mechanism of Hamster Arylamine N-acetyl Transferase 2 Acetylation by Active Site Modification, Site-directed Mutagenesis, and Pre-steady State and Steady State Kinetic Studies,”Biochemistry, 43, 8234-8246 (2004).
38. Guo Zhijun, Vath, Wagner, Carston R., and Hanna, Patrick E., “Mass Spectrometric Investigation of the Mechanism of Inactivation of Hamster Arylamine N-Acetyltransferase 1 by N-Hydroxy-2-Acetylaminofluorene,” Chemical Research in Toxicology , 17, 276-286 (2004). (Paper selected for CRT cover)
37. Wang, Haiqing, Guo Zhijun, Vath, Gregory M., Wagner, Carston R., and Hanna, Patrick E., “Chemical Modification of Hamster Arylamine N-Acetyltransferase 2 with Isozyme-Selective and Non-Selective N-Arylbromoacetamido Reagents,” The Protein Journal, 23, 153-166 (2004).
36. Kim, Jisook, Griesegraber, George, W., Chou, Tsui-fen., and Wagner, Carston R., "Direct Measurement of Nucleoside Monophosphate Delivery from a Phosphoramidate Pronucleotide by Stable Isotope Labeling and LC-ESI-MS/MS," Molecular Pharmaceutics, 1, 102-11 (2004).
35. Kim, Jisook, Drontle, Daniel P., and Wagner, Carston R., "Determination of the Interacellular Metabolism of Amino Acid Nucleoside Phosphoramidates by P-31 NMR," Nucleosides, Nucleotides and Nucleic Acid, 23, 483-493 (2004).
34. Drontle, Daniel P. and Wagner, Carston R., "Nucleoside Amino Acid Phosphoramidates as an Effective Pronucleotide Strategem," Mini-Reviews in Medicinal Chemistry, 4, 409-419 (2004).
33. Guo Zhijun, Vath, Gregory M., Wagner, Carston R., and Hanna, Patrick E., “Arylamine N-Acetyltransferases: Covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene,” Journal of Protein Chemistry, 22, 631-642 (2003).
32. Pineda, Pamela, Kanter, Aaron, McIvor, R. Scott, Benkovic, Stephen J., Rosowsky, Andre and Wagner, Carston R., "Dihydrofolate Reductase Mutant with Exceptional Resistance to Methotrexate but Not to Trimetrexate," Journal of Medicinal Chemistry, 46, 2816-2818 (2003).
31. Song, Heng, Johns, Rachel, Griesgraber, George, W. Wagner, Carston R. and Zimmerman, Cheryl L., "Disposition and Oral Bioavailability in Rats of an Antiviral and Antitumor Amino Acid Phosphoramidate of AZT," Pharmaceutical Research, 20, 448-451, (2003).
30. Carlson, Jonathan C. T., Kanter, Aaron; Thuduppathy, Guruvasuthevan. R., Cody, Vivian, McIvor, R. Scott and Wagner, Carston R., “Designing Protein Dimerizers: The Importance of Ligand Conformational Equilibria,” Journal of the American Chemical Society, 125, 1501-1507 (2003).
29. Crystal, Ronald G., Bitterman, Peter B., Mossman, Brooke, Schwarz, Marvin I., Sheppard, Dean, Almasy, Laura, Chapman, Harold, A., Friedman, Scott L., King, Talmadge E., Leinwand, Leslie, A., Liotta, Lance, Martin, George, R. Schwartz, David A., Wagner, Carston R., and Musson,, Robert A.,“Future Research Directions In Idiopathic Pulmonary Fibrosis: Summary of a National Heart, Lung and Blood Institute Working Group,” Am. J. Respir. Crit. Care Med., 166, 236–246, (2002).
28. Song, Heng, Griesgraber, George W.,Wagner, Carston R., and Zimmerman, Cheryl L.,“Pharmacokinetics of Amino Acid Phosphoramidate Monoesters of AZT in Rats,” Antimicrobial Agents and Chemotherapy, 46, 1357-1363 (2002).
27. Chiaramonte, Molly, Koviach, Jennifer L. Moore, Chad, Iyer, Vidhya I., Wagner, Carston R., Kuchta, Robert, D., “Inhibition of CMP-Sialic Acid Transport into Golgi Vesicles by Nucleoside Monophosphates,” Biochemistry, 40, 14260-14267 (2001).
26. McIntee, Edward J. and Wagner, Carston R., “Amino Acid Phosphoramidate Nucleosides: Potential ADEPT/GDEPT Substrates,” Bioorganic & Medicinal Chemistry Letters, 11, 2803-2805 (2001).
25. Chang, Shu-ling, Griesgraber, George W., and Wagner, Carston R. “Comparison of the Antiviral Activity of Hydrophobic Amino Acid Phosphoramidate Monoesters of 2’, 3’-Dideoxyadenosine (ddA) and 3’-Azido-3’-deoxythymidine (AZT),” Nucleoside, Nucleotide and Nucleic Acids, 20, 1571-1582 (2001).
24. Chang, Shu-ling, Griesgraber, George, W., McIntee, Edward J., Southern, Peter J., and Wagner, Carston R., “Amino Acid Phosphoramidate Monoesters of 3’-Azido-3’-deoxythymidine: The Relationship Between Antiviral Potency and Cellular Decomposition,” Journal of Medicinal Chemistry, 44, 223-231 (2001).
23. Wagner, Carston R., Iyer, Vidhya I., and McIntee, Edward J., “Pronucleotides: Toward the In Vivo Delivery of Antiviral and Antitumor Nucleotides,” Medicinal Research Reviews, 20, 417-451 (2000).
22. Chang, Shu-ling, Griesgraber, George, W., Abraham, Timonthy W., Garg, Tullika, Song, Heng, Zimmerman, Cheryl, L., and Wagner, Carston R., “Synthesis and Antiviral Activity of Amino Acid Carbamate Derivatives of AZT,” Nucleosides, Nucleotides and Nucleic Acids, 19, 87-100 (2000).
21. Iyer, Vidhya I., Griesgraber, George, W., McIntee, Edward J. and Wagner, Carston R., “Synthesis, In Vitro Anti-Breast Cancer Activity and Intracellular Decomposition of Amino Acid Phosphoramidates of AZT,” Journal of Medicinal Chemistry, 43, 2266-2274 (2000).
20. Wagner, Carston R., Chang, Shu-ling, Griesgraber, George W., Song, Heng, McIntee, Edward, J., and Zimmerman, Cheryl L., "Antiviral Nucleoside Drug Delivery Via Amino Acid Phosphoramidates," Nucleosides, Nucleotides and Nucleic Acids, 18, 4&5, 913-919 (1999).
19. Sticha, Kristina R. K., Bergstrom, Carl P., Wagner, Carston R., and Hanna, Patrick E.,"Characterization of Hamster Recombinant Monomorphic and Polymorphic Arylamine N-acetyltransferases: Bioactivation and Mechanism-Based Inactivation Studies with N-hydroxy-2-Acetylaminofluorene," Biochemical Pharmacology, 56, 47-59 (1998).
18. Wagner, Carston R., Ballato, George, Akanni, Abraham O., McIntee, Edward J., Larson, Richard S., Chang, Shu-ling and Abul-Hajj, Yusuf J., "Potent Growth Inhibitory Activity of Zidovudine (AZT) on Cultured Human Breast Cancer Cells and Rat Mammary Tumors," Cancer Research, 57, 2341-2345 (1997).
17. McIntee, Edward J., Remmel, Rory P., Schinazi, Raymond F., Abraham, Timothy W. and Wagner, Carston R., "Probing the Mechanism of Action and Decomposition of Amino Acid Phosphoramidates of Antiviral Nucleosides," Journal of Medicinal Chemistry, 40, 3323-3331 (1997).
16. Sticha, Kristina R. K., Sieg, Christina A., Bergstrom, Carl P., Hanna, Patrick E. and Wagner, Carston R., "Overexpression and Large Scale Purification of Recombinant Hamster Polymorphic Arylamine N-Acetyltransferase as a Dihydrofolate Reductase Fusion Protein," Protein Expression and Purification, 10, 141-153 (1997).
15. Abraham, Timothy W., McIntee, Edward J., Vidhya V. Iyer, Schinazi, Raymond F. and Wagner, Carston R., "Synthesis and Biological Activity and Decomposition Studies of Amino Acid Phosphomonoester Amidates of Acyclovir," Nucleosides, Nucleotides and Nucleic Acids, 16, 2079-2092 (1997).
14. Abraham, Timothy W., Kalman, Thomas I., McIntee, Edward J., and Wagner, Carston R.,"Synthesis and Biological Activity of Aromatic Amino Acid Phosphoramidates of 5-Fluoro-2'-deoxyuridine and 1-b-Arabinofuranosylcytosine: Evidence of Phosphoramidase Activity," Journal of Medicinal Chemistry, 39, 4569-4575 (1996).
13. Wagner, Carston R., Bergstrom, Carl P, Konig, Kristina R., and Hanna, Patrick E., "Arylamine N-Acetyltransferases: Expression in E. coli, Purification, and Substrate Specificities of Recombinant Hamster Monomorphic and Polymorphic Isozymes," Drug Metabolism and Disposition, 24, 245-253 (1996).
12. Evenson, David A., Adams, Joseph A., McIvor, R. Scott, and Wagner, Carton R., "Methotrexate Resistance of Mouse Dihydrofolate Reductase: Effect of Substitution of Phenylalanine-31 by Serine or Tryptophan," Journal of Medicinal Chemistry, 39, 1763-1766 (1996).
11. Wagner, Carston R., McIntee, Edward J., Schinazi, Raymond F., Abraham, Timothy W., "Aromatic Amino Acid Phosphoramidate DI-and Triesters of 3'-Azido-3'-Deoxythymidine (AZT) are Non-Toxic Inhibitors of HIV-1 Receplacation", Bioorganic & Medicinal Chemistry Letters, Vol. 5 (16), 1819-1824 (1995).
10. Bergstrom, Carl P., Wagner, Carston, R., Ann, David K., and Hanna, Patrick E., "Hamster Monomorphic Arylamine N-Acetyltransferase: Expression in Escherichia coli and Purification,"Protein Expression and Purification, 6, 45-55 (1995).
9. Wagner, Carston R., Huang, Zheng, Singleton, Scott F., and Benkovic, Stephen, J., "Molecular Basis of Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase," Biochemistry ,34, 15671-15680 (1995).
8. Huang, Zheng, Wagner, Carston R., and Benkovic, Stephen J., "Non-additivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase," Biochemistry, 33, 11576-11585 (1994).
7. Abraham, Timothy A. and Wagner, Carston R., "A Phosphoramidite-Based Synthesis of Phosphoramidate Amino Acid Diesters of Antiviral Nucleosides," Nucleosides, Nucleotides and Nucleic Acids, 13, 1891-1903, (1994). Print.
6. Wagner, Carston R. and Benkovic, Stephen J., "Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis," Journal of Medicinal Chemistry, 35, 2912-2915 (1992).
5. Wagner, Carston R., Thillet, Joelle, and Benkovic, Stephen J., "Complementary Perturbation of the Kinetic Mechanism and Catalytic Effectiveness of DHFR by Sidechain Interchange," Biochemistry,31, 7834-7840 (1992).
4. Wagner, Carston R., Lee, I. and Benkovic, Stephen J., "Synthesis of Site-Specific Protein Cleaving Reagents: Condensation and Commentary," Chemtracts-Organic Chemistry, 4, 199-201 (1991). Print.
3. Benkovic, Stephen J. and Wagner, Carston R., "Dihydrofolate Reductase: A Paradigm for Drug Design," in Protein Design and the Development of New Therapeutics and Vaccines (J. B. Hook and G. Poste, eds.) Plenum Press, New York, 237-249 (1990). Print.
3. Wagner, Carston R. and Benkovic, Stephen J., "Site-Directed Mutagenesis: A Tool for Enzyme Mechanism Dissection," Trends in Biotechnology, 8, 263-270 (1990).
2. Wagner, Carston R. and Porter, Ned A., "A Phospholipase C Protocol for Phospholipid Peroxidation Analysis," Chemical Research in Toxicology, 1, 274-280 (1988).
1. Porter, Ned A. and Wagner, Carston R., "Phospholipid Autoxidation," Advances in Free Radical Biology and Medicine, 2, 283-323 (1986).
