William (B.J.) Valente

Rheumatology Fellow, 2022 - current

Education

B.A., Chemistry, Spanish Studies — University of Minnesota, Twin Cities

M.D., Ph.D. — University of Washington, Seattle

Honors & Awards

2018-19
- Poncin Fellowship Award – 2018 - Present
2015-18
- Ruth L. Kirchstein NRSA Individual Predoctoral Fellowship
2014-15
- Trainee, Genetic Approaches to Aging Training Grant
2013-16
- Fellowship, Achievement Rewards for College Scientists

Research

Genetic regulation of T cell metabolism and homeostasis

Publications

Jarjour NN, Dalzell TS, Maurice NJ, Wanhainen KM, Peng C, O'Flanagan SD, DePauw TA, Block KE, Valente WJ, Ashby KM, Masopust D, Jameson SC. Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency. Immunity. 2025 Feb 21:S1074-7613(25)00076-7. doi: 10.1016/j.immuni.2025.02.009. Epub ahead of print. PMID: 40023156.
Jarjour NN, Dalzell TS, Maurice NJ, Wanhainen KM, Peng C, DePauw TA, Block KE, Valente WJ, Ashby KM, Masopust D, Jameson SC. Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells. bioRxiv [Preprint]. 2024 Jun 3:2024.05.31.596695. doi: 10.1101/2024.05.31.596695. PMID: 38895229; PMCID: PMC11185530.
V. Voillet, T. Berger, K. McKenna, K. Paulson, W. Tan, K. Smythe, D. Hunter, W. Valente, S. Weaver, J. Campbell, T. Kim, D. Byrd, J. Bielas, R. Pierce, A. Chapuis, R. Gottardo, A. Rongvaux. 2022. An In Vivo Model of Human Macrophages in Metastatic Melanoma. J. Immunology. 209 (3): 606-620.
K. Paulson, V. Voillet, M. McAfee, D. Hunter, F. Wagener, M. Perdicchio, W. Valente, S. Koelle, C. Church, N. Vandeven, H. Thomas, A. Colunga, M. McAfee, J. Iyer, C. Yee, R. Kulikauskas, D. Koelle, R. Pierce, J. Bielas, P. Greenberg, S. Bhatia, R. Gottard. 2018. Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Nat. Commun. 9(3868). PMID: 30250229
G. Zheng, J. Terry, P. Belgrader, P. Ryvkin, Z. Bent, R. Wilson, S. Ziraldo, T. Wheeler, G. McDermott, J. Zhu, M. Gregory, J. Shuga, L. Montesclaros, J. Underwood, D. Masquelier, S. Nishimura, M. Schnall-Levin, P. Wyatt, C. Hindson, R. Bharadwaj, A. Wong, K. Ness, L.W. Beppu, H.J. Deeg, C. Farland, K.R. Loeb, W.J. Valente, N.G. Ericson, E.A. Stevens , J.P. Radich, T.S. Mikkelsen, B.J. Hindson, J.H. Bielas. 2017. Massively parallel digital transcriptional profiling of single cells. Nat. Commun. 8(14049). PMID: 28091601
J. Rose, J. Stephany, W. Valente, B. Trevillian, H. Dang, J. Bielas, D. Maly, D. Fowler. 2017. Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics. Nat. Methods. 14(9): 891 - 896. PMID: 28737741
W. Valente, N. Ericson, A. Long, P. White, F. Marchetti, J. Bielas. 2016. Mitochondrial DNA exhibits resistance to induced point and deletion mutations. Nucleic Acids Res. 44(18): 8513 - 8524. PMID: 27550180.
W. Valente, E. Pienaar, A. Fast, A. Fluitt, S. Whitney, R. Fenton, R. Barletta, O. Chacon, H. Viljoen. 2009. A Kinetic Study of In Vitro Lysis of Mycobacterium smegmatis. Chem. Eng. Sci. 64(9):1955-1952. PMID: 21451732
W.J. Valente and J.H. Bielas. (2016). Mitochondrial Mutagenesis in Cancer. In D.M. Hockenbery (Ed.), Mitochondria and Cancer (pp. 131-148). New York: Humana Press.

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