Duncan Smart

Resident; future Cardiovascular fellow

Education

B.S., Biochemistry - University of Texas at Austin

M.D., Ph.D - Vanderbilt University School of Medicine

Honors & Awards

NIH NHLBI Individual Predoctoral National Research Service Award (F30 Fellowship)
Pre-doctoral Fellowship of the American Heart Association
AHA Council on Hypertension Top Trainee Advocacy Award
Vanderbilt MSTP Travel Award
International Society of Hypertension Travel Awarrd
Vanderbilt BRET Travel Award for AHA Basic Cardiovascular Sciences Conference
Vanderbilt Molecular, Physiology, and Biophysics Travel Award
Model Senior Thesis Aard
Kemp-Forman Memorial Endowed Presidential Scholarship
Edward Sibley Lewis, MD Endowed Presidential Scholarship
Ralph Steiner, MD Endowed Scholarship
Colleges of Natural Sciences, Liberal Arts Scholar

Research

TBD

Publications

Subati T, Kim K, Yang Z, Murphy MB, Van Amburg JC, Christopher IL, Dougherty OP, Woodall KK, Smart CD, Johnson JE, Fogo AB, Amarnath V, Agrawal V, Barnett JV, Saffitz JE, Murray KT. Oxidative Stress Causes Mitochondrial and Electrophysiologic Dysfunction to Promote Atrial Fibrillation in Pitx2+/-Mice. Circ Arrhythm Electrophysiol. 2025 Feb 24:e013199. doi: 10.1161/CIRCEP.124.013199. Epub ahead of print. PMID: 39989351.
Murphy MB, Yang Z, Subati T, Farber-Eger E, Kim K, Blackwell DJ, Fleming MR, Stark JM, Van Amburg JC, Woodall KK, Van Beusecum JP, Agrawal V, Smart CD, Pitzer A, Atkinson JB, Fogo AB, Bastarache JA, Kirabo A, Wells QS, Madhur MS, Barnett JV, Murray KT. LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation. Cardiovasc Res. 2024 Jul 2;120(8):899-913. doi: 10.1093/cvr/cvae036. PMID: 38377486; PMCID: PMC11218690.
Smart CD, Fehrenbach DJ, Wassenaar JW, Agrawal V, Fortune NL, Dixon DD, Cottam MA, Hasty AH, Hemnes AR, Doran AC, Gupta DK, Madhur MS. Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure. Cardiovasc Res. 2023 Oct 24;119(13):2312-2328. doi: 10.1093/cvr/cvad093. PMID: 37314125; PMCID: PMC10597637.
Smart CD, Madhur MS. The immunology of heart failure with preserved ejection fraction. Clin Sci (Lond). 2023 Aug 31;137(16):1225-1247. doi: 10.1042/CS20230226. PMID: 37606086; PMCID: PMC10959189.
Alexander MR, Dale BL, Smart CD, Elijovich F, Wogsland CE, Lima SM, Irish JM, Madhur MS. Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension. JACC Basic Transl Sci. 2023 Jan 4;8(3):319-336. doi: 10.1016/j.jacbts.2022.09.007. PMID: 37034287; PMCID: PMC10077123.
Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS. A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage. Circ Res. 2022 Oct 14;131(9):731-747. doi: 10.1161/CIRCRESAHA.121.320625. Epub 2022 Sep 28. Erratum in: Circ Res. 2023 Mar 3;132(5):e95. doi: 10.1161/RES.0000000000000599. PMID: 36169218; PMCID: PMC9588739.
Patrick DM, de la Visitación N, Krishnan J, Chen W, Ormseth MJ, Stein CM, Davies SS, Amarnath V, Crofford LJ, Williams JM, Zhao S, Smart CD, Dikalov S, Dikalova A, Xiao L, Van Beusecum JP, Ao M, Fogo AB, Kirabo A, Harrison DG. Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus. JCI Insight. 2022 Jul 8;7(13):e136678. doi: 10.1172/jci.insight.136678. PMID: 35608913; PMCID: PMC9310530.
McNew KL, Abraham A, Sack DE, Smart CD, Pettway YD, Falk AC, Lister RL, Faucon AB, Bejan CA, Capra JA, Aronoff DM, Boyd KL, Moore DJ. Vascular alterations impede fragile tolerance to pregnancy in type 1 diabetes. F S Sci. 2022 May;3(2):148-158. doi: 10.1016/j.xfss.2022.02.001. Epub 2022 Feb 5. PMID: 35560012; PMCID: PMC9850286.
Van Beusecum JP, Barbaro NR, Smart CD, Patrick DM, Loperena R, Zhao S, de la Visitacion N, Ao M, Xiao L, Shibao CA, Harrison DG. Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension. Circ Res. 2021 Nov 12;129(11):975-991. doi: 10.1161/CIRCRESAHA.121.319643. Epub 2021 Sep 27. PMID: 34565181; PMCID: PMC9125747.
Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, Wang M, Zhao S, Dai C, Smart CD, Liu J, Luo X, Deng Y, Tan L, Lv SJ, Davidson SM, Locasale JW, Lorenzi PL, Malloy CR, Gillette TG, Vander Heiden MG, Scherer PE, Szweda LI, Fu G, Wang ZV. PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart. Circulation. 2021 Aug 31;144(9):712-727. doi: 10.1161/CIRCULATIONAHA.121.054885. Epub 2021 Jun 9. PMID: 34102853; PMCID: PMC8405569.
Madhur MS, Elijovich F, Alexander MR, Pitzer A, Ishimwe J, Van Beusecum JP, Patrick DM, Smart CD, Kleyman TR, Kingery J, Peck RN, Laffer CL, Kirabo A. Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic? Circ Res. 2021 Apr 2;128(7):908-933. doi: 10.1161/CIRCRESAHA.121.318052. Epub 2021 Apr 1. PMID: 33793336; PMCID: PMC8023750.
Chen Y, Dale BL, Alexander MR, Xiao L, Ao M, Pandey AK, Smart CD, Davis GK, Madhur MS. Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice. Cardiovasc Res. 2021 Mar 21;117(4):1217-1228. doi: 10.1093/cvr/cvaa187. PMID: 32609312; PMCID: PMC7983008.
Alexander MR, Schoeder CT, Brown JA, Smart CD, Moth C, Wikswo JP, Capra JA, Meiler J, Chen W, Madhur MS. Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species. FASEB J. 2020 Dec;34(12):15946-15960. doi: 10.1096/fj.202001808R. Epub 2020 Oct 4. PMID: 33015868; PMCID: PMC7675292.
Dale BL, Pandey AK, Chen Y, Smart CD, Laroumanie F, Ao M, Xiao L, Dikalova AE, Dikalov SI, Elijovich F, Foss JD, Barbaro NR, Van Beusecum JP, Deger SM, Alsouqi A, Itani HA, Norlander AE, Alexander MR, Zhao S, Ikizler TA, Algood HMS, Madhur MS. Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction. JCI Insight. 2019 Apr 23;5(11):e129278. doi: 10.1172/jci.insight.129278. PMID: 31013256; PMCID: PMC6629096.
Smart CD, Madhur MS. Recent Cardiovascular Research highlights from the Americas. Cardiovasc Res. 2019 Feb 1;115(2):e22-e23. doi: 10.1093/cvr/cvy229. PMID: 30668677; PMCID: PMC6736084.

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