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Benjamin H Singer is currently an Associate Professor in Medicine in the Division of Pulmonary and Critical Care Medicine at the University of Michigan. Dr. Singer’s research focuses on basic and translational studies of long-term brain injury after critical illness, specifically sepsis. These studies utilize animal models of sepsis and patient autopsy specimens to examine the immune and vascular responses to sepsis in the brain that persist for weeks to months after the outward signs of illness have resolved. How preexisting neuropathology, such as beta amyloid, might predispose sepsis survivors to brain dysfunction is a major area of interest. This work aims to identify strategies to minimize and rehabilitate ongoing brain injury in sepsis survivors. Areas of particular clinical focus include the care of patients with advanced neuromuscular disease requiring chronic assisted ventilation. He is medical director of the Medicine Pulmonary service at UM hospital which specializes in the care of patients who need chronic assisted ventilation or who are recovering from critical illness. He completed all of his academic and clinical training at the University of Michigan. Outside of work he enjoys woodworking with his family.
Benjamin H Singer is currently an Associate Professor in Medicine in the Division of Pulmonary and Critical Care Medicine at the University of Michigan. Dr. Singer’s research focuses on basic and translational studies of long-term brain injury after critical illness, specifically sepsis. These studies utilize animal models of sepsis and patient autopsy specimens to examine the immune and vascular responses to sepsis in the brain that persist for weeks to months after the outward signs of illness have resolved. How preexisting neuropathology, such as beta amyloid, might predispose sepsis survivors to brain dysfunction is a major area of interest. This work aims to identify strategies to minimize and rehabilitate ongoing brain injury in sepsis survivors. Areas of particular clinical focus include the care of patients with advanced neuromuscular disease requiring chronic assisted ventilation. He is medical director of the Medicine Pulmonary service at UM hospital which specializes in the care of patients who need chronic assisted ventilation or who are recovering from critical illness. He completed all of his academic and clinical training at the University of Michigan. Outside of work he enjoys woodworking with his family.
Scott J Denstaedt is currently an Assistant Professor of Medicine in the Division of Pulmonary and Critical Care Medicine at the University of Michigan. Dr. Denstaedt currently works in basic and translational studies of long-term morbidity and mortality after sepsis. He is interested in persistent alterations in innate immunity after sepsis and how these affect patient outcomes. He has particular interest in epigenetic mechanisms of monocyte and macrophage reprogramming that predispose patients to subsequent complications. Dr. Denstaedt completed his Pulmonary and Critical Care fellowship training at the University of Michigan. Outside of the lab and work he likes brewing beer and tending to his hop garden.
Scott J Denstaedt is currently an Assistant Professor of Medicine in the Division of Pulmonary and Critical Care Medicine at the University of Michigan. Dr. Denstaedt currently works in basic and translational studies of long-term morbidity and mortality after sepsis. He is interested in persistent alterations in innate immunity after sepsis and how these affect patient outcomes. He has particular interest in epigenetic mechanisms of monocyte and macrophage reprogramming that predispose patients to subsequent complications. Dr. Denstaedt completed his Pulmonary and Critical Care fellowship training at the University of Michigan. Outside of the lab and work he likes brewing beer and tending to his hop garden.
Michael Newstead
Michael Newstead
Lab Manager
Lab Manager
Joshua Stoolman is a Research Investigator in the Division of Pulmonary and Critical Care Medicine. Josh's current work focuses on metabolic control of innate immune responses and its implications on immune responses during infection, injury and aging. His focus is better understanding how mitochondria-derived signals resolve inflammatory signals and promote tissue recovery and return to homeostasis. Josh got his BA in Biology from Kalamazoo College, and his PhD in immunology in the laboratory of Dr. Benjamin Segal studying the mechanisms driving immune cell migration to different areas of the central nervous system in an animal model of multiple sclerosis. He moved to Northwestern University for his post-doc in Dr. Navdeep Chandel's lab where he studied mitochondrial control of innate immune responses in myeloid cell populations.
Joshua Stoolman is a Research Investigator in the Division of Pulmonary and Critical Care Medicine. Josh's current work focuses on metabolic control of innate immune responses and its implications on immune responses during infection, injury and aging. His focus is better understanding how mitochondria-derived signals resolve inflammatory signals and promote tissue recovery and return to homeostasis. Josh got his BA in Biology from Kalamazoo College, and his PhD in immunology in the laboratory of Dr. Benjamin Segal studying the mechanisms driving immune cell migration to different areas of the central nervous system in an animal model of multiple sclerosis. He moved to Northwestern University for his post-doc in Dr. Navdeep Chandel's lab where he studied mitochondrial control of innate immune responses in myeloid cell populations.
Andrew Stephens, PhD
Andrew Stephens, PhD
Andrew Stephens is a Postdoctoral Fellow in Pulmonary & Critical Care Medicine, supported by the Michigan Medicine NIH T32 Multidisciplinary Training Program in Lung Disease. His research focuses on developing rapid and scalable microfluidics immunoassays to enable patient-personalized approaches to critical care. Andrew completed his PhD and MS in Mechanical Engineering at the University of Michigan, and B.S. in Mechanical Engineering at Bradley University in Peoria, IL. In his free time, Andrew enjoys playing golf, skiing, traveling, and cheering for Michigan sports.
Andrew Stephens is a Postdoctoral Fellow in Pulmonary & Critical Care Medicine, supported by the Michigan Medicine NIH T32 Multidisciplinary Training Program in Lung Disease. His research focuses on developing rapid and scalable microfluidics immunoassays to enable patient-personalized approaches to critical care. Andrew completed his PhD and MS in Mechanical Engineering at the University of Michigan, and B.S. in Mechanical Engineering at Bradley University in Peoria, IL. In his free time, Andrew enjoys playing golf, skiing, traveling, and cheering for Michigan sports.
Kate Giffin is a PhD candidate in the Neuroscience Graduate Program. She is interested in the mechanisms of long-term brain dysfunction after sepsis. Kate uses a range of neuroscience techniques, from transcriptomics to behavior, to study how sepsis can change the immune cells of the brain, microglia, and how that can ultimately disrupt brain function. Before starting her PhD studies, Kate completed her AS at Beaufort County Community College, her BA in Biology at the University of North Carolina at Chapel Hill, and a post-baccalaureate research program at UNC-CH with Dr. Joyce Besheer. In addition to scientific pursuits, Kate loves to write, travel, and explore the outdoors.
Kate Giffin is a PhD candidate in the Neuroscience Graduate Program. She is interested in the mechanisms of long-term brain dysfunction after sepsis. Kate uses a range of neuroscience techniques, from transcriptomics to behavior, to study how sepsis can change the immune cells of the brain, microglia, and how that can ultimately disrupt brain function. Before starting her PhD studies, Kate completed her AS at Beaufort County Community College, her BA in Biology at the University of North Carolina at Chapel Hill, and a post-baccalaureate research program at UNC-CH with Dr. Joyce Besheer. In addition to scientific pursuits, Kate loves to write, travel, and explore the outdoors.
Grace Roughton
Grace Roughton
Grace Roughton is the lab technician for the Singer-Denstaedt lab. She helps with day-to-day activities of the lab such as conducting experiments, managing the mice colonies, and ordering supplies. Grace completed her BS in biology from the University of Iowa, where she also held a post-baccalaureate position in a cancer research lab. In her free time Grace likes hiking, knitting/embroidering/handcrafting, and binging TV shows.
Grace Roughton is the lab technician for the Singer-Denstaedt lab. She helps with day-to-day activities of the lab such as conducting experiments, managing the mice colonies, and ordering supplies. Grace completed her BS in biology from the University of Iowa, where she also held a post-baccalaureate position in a cancer research lab. In her free time Grace likes hiking, knitting/embroidering/handcrafting, and binging TV shows.
Niyati Puranik is an undergraduate researcher, continuing as a Master's student in Bioinformatics after completing her Bachelor's in Biomedical Engineering at the University of Michigan. She is interested in utilizing analytical techniques to uncover the mechanisms behind cognitive and other physiological deficits following recovery from sepsis. She has published prior work in neuroscience through the V.A. Medical Center and Oregon Health & Science University in Portland, Oregon, her hometown. In her free time, she enjoys reading, playing volleyball, and listening to music.
Niyati Puranik is an undergraduate researcher, continuing as a Master's student in Bioinformatics after completing her Bachelor's in Biomedical Engineering at the University of Michigan. She is interested in utilizing analytical techniques to uncover the mechanisms behind cognitive and other physiological deficits following recovery from sepsis. She has published prior work in neuroscience through the V.A. Medical Center and Oregon Health & Science University in Portland, Oregon, her hometown. In her free time, she enjoys reading, playing volleyball, and listening to music.
Kevin Chen
Kevin Chen
Kevin Chen is an undergraduate researcher and student in Biomedical Engineering at the College of Engineering, University of Michigan. Kevin has experience in cutting-edge biotechnology research, development, manufacture, and management. Kevin focused on the research and development of digital ELISA, and now shifting toward technological applications in animal and patient research. In his free time, Kevin likes playing his saxophone, traveling, and contemplating over the purpose of life.
Kevin Chen is an undergraduate researcher and student in Biomedical Engineering at the College of Engineering, University of Michigan. Kevin has experience in cutting-edge biotechnology research, development, manufacture, and management. Kevin focused on the research and development of digital ELISA, and now shifting toward technological applications in animal and patient research. In his free time, Kevin likes playing his saxophone, traveling, and contemplating over the purpose of life.
Grace Randolph
Grace Randolph
Grace Randolph is an undergraduate researcher and a junior majoring in Biopsychology, Cognition, and Neuroscience. She is interested in how sepsis can affect the brain's cognitive function. In her free time, she likes to run/workout, listen to music, and travel.
Grace Randolph is an undergraduate researcher and a junior majoring in Biopsychology, Cognition, and Neuroscience. She is interested in how sepsis can affect the brain's cognitive function. In her free time, she likes to run/workout, listen to music, and travel.
Simran Tumber
Simran Tumber
Simran Tumber is an undergraduate researcher and a sophomore in Biopsychology, Cognition, and Neuroscience at the University of Michigan. Simran is interested in utilizing standard flow cytometry to study the long-term effects of sepsis on the lungs using mouse models. Beyond research, she enjoys working out, traveling, and spending time with family and friends.
Simran Tumber is an undergraduate researcher and a sophomore in Biopsychology, Cognition, and Neuroscience at the University of Michigan. Simran is interested in utilizing standard flow cytometry to study the long-term effects of sepsis on the lungs using mouse models. Beyond research, she enjoys working out, traveling, and spending time with family and friends.
Leah Wheaton
Leah Wheaton
Leah Wheaton is an undergraduate researcher and a sophomore studying Biopsychology, Cognition, and Neuroscience in the College of LSA at the University of Michigan. Leah is interested in investigating how sepsis affects brain dysfunction. She was trained in Phlebotomy at MidMichigan College and took courses at Delta College while she attended Coleman High School. She enjoys bowling and spending time with her family.
Leah Wheaton is an undergraduate researcher and a sophomore studying Biopsychology, Cognition, and Neuroscience in the College of LSA at the University of Michigan. Leah is interested in investigating how sepsis affects brain dysfunction. She was trained in Phlebotomy at MidMichigan College and took courses at Delta College while she attended Coleman High School. She enjoys bowling and spending time with her family.
Nhi Vo
Nhi Vo
Nhi Vo is a 3rd-year undergraduate researcher majoring in Neuroscience at the University of Michigan. Nhi is interested in investigating how neurogenesis in the dentate gyrus is affected in mice affected by sepsis. Outside of research, she enjoys rock climbing, cooking, long walks, and journaling in her free time.
Nhi Vo is a 3rd-year undergraduate researcher majoring in Neuroscience at the University of Michigan. Nhi is interested in investigating how neurogenesis in the dentate gyrus is affected in mice affected by sepsis. Outside of research, she enjoys rock climbing, cooking, long walks, and journaling in her free time.
Lab Alumni and Current Positions
Lab Alumni and Current Positions
Keishla González Pérez – former summer undergraduate student, currently finishing undergrad in Biomedical Sciences at Pontifical Catholic University of Puerto Rico, Ponce Campus
Keishla González Pérez – former summer undergraduate student, currently finishing undergrad in Biomedical Sciences at Pontifical Catholic University of Puerto Rico, Ponce Campus
Samin Hassan – former undergraduate thesis student
Samin Hassan – former undergraduate thesis student
Zeshan Fahim – former undergraduate student, current Medical Student at Virtua Health College of Medicine and Life Sciences at Rowan University
Zeshan Fahim – former undergraduate student, current Medical Student at Virtua Health College of Medicine and Life Sciences at Rowan University
Brett Arenberg – former undergraduate student
Brett Arenberg – former undergraduate student
Huiyin Deng, MD - former visiting Phd student, current Postdoctoral Fellow, Central South University, China
Huiyin Deng, MD - former visiting Phd student, current Postdoctoral Fellow, Central South University, China
Chitra Parthasarathy – former Research Assistant, current Research Assistant, University of Michigan
Chitra Parthasarathy – former Research Assistant, current Research Assistant, University of Michigan
Avnee Kumar, MD – Post-doctoral Fellow and Attending Physician, University of California San Diego
Avnee Kumar, MD – Post-doctoral Fellow and Attending Physician, University of California San Diego
Zhuoer Zeng – former undergraduate thesis student, current Graduate Student, University of California, Davis
Zhuoer Zeng – former undergraduate thesis student, current Graduate Student, University of California, Davis
Alex Hjelmaas, MD – Anesthesia Resident, Northwestern University
Alex Hjelmaas, MD – Anesthesia Resident, Northwestern University
Ramya Ghantasala, MD – Pediatric Neurology Resident, Northshore Medical Center
Ramya Ghantasala, MD – Pediatric Neurology Resident, Northshore Medical Center
Annie Zhao – former undergraduate student, currently at Epic Software
Annie Zhao – former undergraduate student, currently at Epic Software
Marc Padilla – former summer undergraduate student, Neuroscience Graduate Program PhD Student, University of Michigan
Marc Padilla – former summer undergraduate student, Neuroscience Graduate Program PhD Student, University of Michigan
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