How do we make patients whole again after surviving critical illness?
Advances in medical care have dramatically improved survival of critical illness over the last several decades. As more patients survive to leave the doors of the intensive care unit, it has become apparent that the effects of severe infections such as pneumonia and sepsis do not end at discharge from the ICU or even discharge from the hospital.
Advances in medical care have dramatically improved survival of critical illness over the last several decades. As more patients survive to leave the doors of the intensive care unit, it has become apparent that the effects of severe infections such as pneumonia and sepsis do not end at discharge from the ICU or even discharge from the hospital.
Between 30 and 50% of sepsis survivors experience significant, persistent disorders of mood and cognition, reflecting ongoing brain dysfunction. Risks of other organ dysfunctions, such as cardiovascular disease, kidney failure, and recurrent respiratory illnesses are increased, as well.
Between 30 and 50% of sepsis survivors experience significant, persistent disorders of mood and cognition, reflecting ongoing brain dysfunction. Risks of other organ dysfunctions, such as cardiovascular disease, kidney failure, and recurrent respiratory illnesses are increased, as well.
Our lab focuses on how acute illnesses, like sepsis and pneumonia, cause persistent changes in immune and brain function, and whether these trajectories can be changed by treatments that modulate the function of the innate immune system.
Our lab focuses on how acute illnesses, like sepsis and pneumonia, cause persistent changes in immune and brain function, and whether these trajectories can be changed by treatments that modulate the function of the innate immune system.
We are part of the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, in the University of Michigan Medical School.
We are part of the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, in the University of Michigan Medical School.
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